COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY

1 . A compound of Formula I:

or a pharmaceutically acceptable salt thereof or a tautomer thereof, wherein:

X 1 is selected from the group consisting of O, S, N, NR 2 , and CR 5 ;

X 2 is selected from the group consisting of O, S, N, NR 4 , and CR 5 ;

each is independently a single bond or a double bond, provided that the five-membered ring comprising X 1 and X 2 is heteroaryl; and

the 6-membered ring

is aromatic;

one of R 1a , R 1b , R 1c , and R 1d is selected from the group consisting of: R* and —OR*; and each of the three remaining R 1a , R 1b , R 1c , and R 1d is an independently selected R**; wherein:

R* is selected from the group consisting of:

C 3-8 cycloalkyl or C 3-8 cycloalkenyl, each optionally substituted with 1-4 independently selected R g ;

heterocyclyl or heterocycloalkenyl, wherein each of the heterocyclyl and heterocycloalkenyl has 3-16 ring atoms, wherein 1-3 ring atoms are heteroatoms, each independently selected from the group consisting of N, N(H), N(R d ), O, and S(O) 0-2 , wherein each of the heterocyclyl and heterocycloalkenyl is optionally substituted with 1-4 independently selected R g ;

heteroaryl of 5-10 ring atoms, wherein 1-4 ring atoms are heteroatoms, each independently selected from the group consisting of N, N(H), N(R d ), O, and S(O) 0-2 and wherein the heteroaryl ring is optionally substituted with 1-4 independently selected R g ; and

C 6-10 aryl, which is optionally substituted with 1-4 independently selected R g ; and

each R** is independently selected from the group consisting of: H; halo; cyano; C 1-6 alkyl optionally substituted with 1-2 R a ; C 2-6 alkenyl; C 2-6 alkynyl; C 1-4 haloalkyl; C 1-4 alkoxy; C 1-4 haloalkoxy; -L 3 -L 4 -R*; —S(O) 1-2 (C 1-4 alkyl); —S(O)(═NH)(C 1-4 alkyl); SF 5 ; —NR e1 R f1 ; —OH; —S(O) 1-2 (NR′R″); —C 1-4 thioalkoxy; —NO 2 ; —C(═O)(C 1-4 alkyl); —C(═O)O(C 1-4 alkyl); —C(═O)OH; and —C(═O)N(R′)(R″);

W is selected from the group consisting of C(═O); C(═S); S(O) 1-2 ; C(═NR d ); C(═NH); C(═C—NO 2 ); S(═O)═N(R d ); and S(═O)═NH;

Q-A is defined according to (A) or (B) below:

Q is selected from the group consisting of: NH and N(C 1-6 alkyl), wherein the C 1-6 alkyl is optionally substituted with 1-2 independently selected R a ; and

A is:

(i) —(Y A1 ) n —Y A2 , wherein:

n is 0 or 1;

Y A1 is C 1-6 alkylene, which is optionally substituted with 1-6 independently selected R a ; and

Y A2 is

(a) C 3-20 cycloalkyl or C 3-20 cycloalkenyl, each of which is optionally substituted with 1-4 R b ,

(b) C 6-20 aryl, which is optionally substituted with 1-4 R c ;

(c) heteroaryl of 5-20 ring atoms, wherein 1-3 ring atoms are heteroatoms, each independently selected from the group consisting of N, N(H), N(R d ), O, and S(O) 0-2 , and wherein the heteroaryl ring is optionally substituted with 1-4 independently selected R c ; or

(d) heterocyclyl or heterocycloalkenyl, each of 3-16 ring atoms, wherein 1-3 ring atoms are heteroatoms, each independently selected from the group consisting of N, N(H), N(R d ), O, and S(O) 0-2 , and wherein each of the heterocyclyl and heterocycloalkenyl ring is optionally substituted with 1-4 independently selected R b , or

(ii) C 1-10 alkyl, which is optionally substituted with 1-6 independently selected R a , or

Q and A, taken together, form:

and

E is a ring of 3-16 ring atoms, wherein aside from the nitrogen atom present, 0-3 additional ring atoms are heteroatoms, each independently selected from the group consisting of N, N(H), N(R d ), O, and S(O) 0-2 , and wherein the ring is optionally substituted with 1-4 independently selected R b ,

each occurrence of R 2 is independently selected from the group consisting of:

(i) C 1-6 alkyl, which is optionally substituted with 1-2 independently selected R a ;

(ii) C 3-6 cycloalkyl or C 3-6 cycloalkenyl, wherein the cycloalkyl or cycloalkenyl is optionally substituted with 1-4 independently selected R b ;

(iii) heterocyclyl or heterocycloalkenyl, each of 3-10 ring atoms, wherein 1-3 ring atoms are heteroatoms, each independently selected from the group consisting of N, N(H), N(R d ), O, and S(O) 0-2 , and wherein the heterocyclyl is optionally substituted with 1-4 independently selected R b ;

(iv) C 6-10 aryl, which is optionally substituted with 1-4 independently selected R b ;

(v) heteroaryl of 5-10 ring atoms, wherein 1-3 ring atoms are heteroatoms, each independently selected from the group consisting of N, N(H), N(R d ), O, and S(O) 0-2 , and wherein the heteroaryl is optionally substituted with 1-4 independently selected R b ;

(vi) —C(O)(C 1-4 alkyl), which is optionally substituted with 1-2 independently selected R a ;

(vii) —C(O)(C 6-10 aryl), which is optionally substituted with 1-2 independently selected R c ;

(viii) —C(O)(heteroaryl), wherein the heteroaryl has 5-10 ring atoms, wherein 1-3 ring atoms are heteroatoms, each independently selected from the group consisting of N, N(H), N(R d ), O, and S(O) 0-2 ; and wherein the heteroaryl is optionally substituted with 1-2 independently selected R c ;

(vii) —C(O)O(C 1-4 alkyl);

(viii) —CON(R′)(R″);

(ix) —S(O) 1-2 (NR′R″);

(x) —S(O) 1-2 (C 1-4 alkyl), which is optionally substituted with 1-2 independently selected R a ;

(xiii) —S(O) 1-2 (C 6-10 aryl), which is optionally substituted with 1-2 independently selected R c ;

(xiv) —S(O) 1-2 (heteroaryl), wherein the heteroaryl has 5-10 ring atoms, wherein 1-3 ring atoms are heteroatoms, each independently selected from the group consisting of N, N(H), N(R d ), O, and S(O) 0-2 ; and wherein the heteroaryl is optionally substituted with 1-2 independently selected R c ;

(xi) —OH;

(xii) C 1-4 alkoxy; and

(xiii) H;

R 4 is selected from the group consisting of H and C 1-6 alkyl optionally substituted with 1-3 independently selected R a ;

R 5 is selected from the group consisting of H; halo; —OH; —C 1-4 alkyl; —C 1-4 haloalkyl; C 1-4 alkoxy; C 1-4 haloalkoxy; —C(═O)O(C 1-4 alkyl); —C(═O)(C 1-4 alkyl); —C(═O)OH; —CON(R′)(R″); —S(O) 1-2 (NR′R″); —S(O) 1-2 (C 1-4 alkyl); cyano, and C 3-6 cycloalkyl or C 3-6 cycloalkenyl, each optionally substituted with 1-4 independently selected C 1-4 alkyl;

R 6 is selected from the group consisting of H; C 1-6 alkyl optionally substituted with 1-3 independently selected R a ; —OH; C 1-4 alkoxy; C(═O)H; C(═O)(C 1-4 alkyl); C 6-10 aryl optionally substituted with 1-4 independently selected C 1-4 alkyl; and heteroaryl of 5-10 ring atoms, wherein 1-4 ring atoms are heteroatoms, each independently selected from the group consisting of N, N(H), N(R d ), O, and S(O) 0-2 and wherein the heteroaryl ring is optionally substituted with 1-4 independently selected C 1-4 alkyl;

each occurrence of R a is independently selected from the group consisting of: —OH; —F; —Cl; —Br; —NR e R f ; C 1-4 alkoxy; C 1-4 haloalkoxy; —C(═O)O(C 1-4 alkyl); —C(═O)(C 1-4 alkyl); —C(═O)OH; —CON(R′R″); —S(O) 1-2 (NR′R″); —S(O) 1-2 (C 1-4 alkyl); cyano; C 6-10 aryl; heteroaryl of 5-10 ring atoms, wherein 1-3 ring atoms are heteroatoms, each independently selected from the group consisting of N, N(H), N(R d ), O, and S(O) 0-2 ; heterocyclyl or heterocycloalkenyl, each of 3-10 ring atoms, wherein 1-3 ring atoms are heteroatoms, each independently selected from the group consisting of N, N(H), N(R d ), O, and S(O) 0-2 ; and C 3-6 cycloalkyl or C 3-6 cycloalkenyl, each optionally substituted with 1-4 independently selected C 1-4 alkyl;

each occurrence of R a1 is independently selected from the group consisting of: —OH; —F; —Cl; —Br; —NR e R f ; C 1-4 alkoxy; C 1-4 haloalkoxy; —C(═O)O(C 1-4 alkyl); —C(═O)(C 1-4 alkyl); —C(═O)OH; —CON(R′)(R″); —S(O) 1-2 (NR′R″); —S(O) 1-2 (C 1-4 alkyl); cyano; C 3-6 cycloalkyl or C 3-6 cycloalkenyl, each optionally substituted with 1-4 independently selected C 1-4 alkyl; C 6-10 aryl optionally substituted with 1-4 independently selected C 1-4 alkyl; and heteroaryl of 5-10 ring atoms, wherein 1-3 ring atoms are heteroatoms, each independently selected from the group consisting of N, N(H), N(R d ), O, and S(O) 0-2 wherein the heteroaryl ring is optionally substituted with 1-4 independently selected C 1-4 alkyl;

each occurrence of R b is independently selected from the group consisting of: C 1-10 alkyl optionally substituted with 1-6 independently selected R a ; C 1-4 haloalkyl; —OH; oxo; —F; —Cl; —Br; —NR e1 R f1 ; C 1-4 alkoxy; C 1-4 haloalkoxy; —C(═O)(C 1-10 alkyl); —C(═O)O(C 1-4 alkyl); —C(═O)OH; —C(═O)N(R′)(R″); —S(O) 1-2 (NR′R″); —S(O) 1-2 (C 1-4 alkyl); cyano; and -L 1 -L 2 -R h ;

each occurrence of R c is independently selected from the group consisting of: halo; cyano; C 1-10 alkyl which is optionally substituted with 1-6 independently selected R a ; C 2-6 alkenyl; C 2-6 alkynyl; C 1-4 alkoxy; C 1-4 haloalkoxy; —S(O) 1-2 (C 1-4 alkyl); —NR e1 R f1 ; —OH; —S(O) 1-2 (NR′R″); —C 1-4 thioalkoxy; —NO 2 ; —C(═O)(C 1-10 alkyl); —C(═O)O(C 1-4 alkyl); —C(═O)OH; —C(═O)N(R′)(R″); and -L 1 -L 2 -R h ;

R d is selected from the group consisting of: C 1-6 alkyl optionally substituted with 1-3 substituents each independently selected from the group consisting of halo and OH; C 3-6 cycloalkyl or C 3-6 cycloalkenyl, each optionally substituted with 1-3 substituents each independently selected from the group consisting of halo and OH; —C(O)(C 1-4 alkyl); —C(O)O(C 1-4 alkyl); —CON(R′)(R″); —S(O) 1-2 (NR′R″); —S(O) 1-2 (C 1-4 alkyl); —OH; and C 1-4 alkoxy;

each occurrence of R e and R f is independently selected from the group consisting of: H; C 1-6 alkyl; C 1-6 haloalkyl; C 3-6 cycloalkyl or C 3-6 cycloalkenyl; —C(O)(C 1-4 alkyl); —C(O)O(C 1-4 alkyl); —CON(R′)(R″); —S(O) 1-2 (NR′R″); —S(O) 1-2 (C 1-4 alkyl); —OH; and C 1-4 alkoxy; or R e and R f together with the nitrogen atom to which each is attached forms a ring of 3-8 ring atoms, wherein the ring has: (a) 1-7 ring carbon atoms, each of which is substituted with 1-2 substituents independently selected from the group consisting of H and C 1-3 alkyl; and (b) 0-3 ring heteroatoms (in addition to the nitrogen atom attached to R e and R), which are each independently selected from the group consisting of N(R d ), NH, O, and S;

each occurrence of R e1 and R f1 is independently selected from the group consisting of: H; C 1-6 alkyl; C 1-6 haloalkyl; —C(O)(C 1-4 alkyl); —C(O)O(C 1-4 alkyl); —CON(R′)(R″); —S(O) 1-2 (NR′R″); —S(O) 1-2 (C 1-4 alkyl); —OH; and C 1-4 alkoxy;

each occurrence of R g is independently selected from the group consisting of: halo; cyano; C 1-6 alkyl optionally substituted with 1-2 independently selected R a1 ; C 1-4 haloalkyl; C 1-6 alkoxy optionally substituted with 1-2 independently selected Rai; C 1-4 haloalkoxy; C 3-8 cycloalkyl optionally substituted with C 1-6 alkyl or cyano; C 6-10 aryl; S(O) 1-2 (C 1-4 alkyl); —NR e R f ; —OH; oxo; —S(O) 1-2 (NR′R″); —C 1-4 thioalkoxy; —NO 2 ; —C(═O)(C 1-4 alkyl); —C(═O)O(C 1-4 alkyl); —C(═O)OH; —Si(C 1-4 alkyl) 4 ; and —C(═O)N(R′)(R″);

-L 1 is a bond or C 1-3 alkylene;

-L 2 is —O—, —N(H)—, —S(O) 0-2 —, or a bond;

R h is selected from the group consisting of:

C 3-8 cycloalkyl or C 3-8 cycloalkenyl, each optionally substituted with 1-4 substituents independently selected from the group consisting of halo, C 1-4 alkyl, and C 1-4 haloalkyl (in certain embodiments, it is provided that when R h is C 3-6 cycloalkyl or C 3-6 cycloalkenyl, each optionally substituted with 1-4 substituents independently selected C 1-4 alkyl, -L 1 is a bond, or -L 2 is —O—, —N(H)—, or —S—);

heterocyclyl or heterocycloalkenyl, wherein each of the heterocyclyl and heterocycloalkenyl has 3-16 ring atoms, wherein 1-3 ring atoms are heteroatoms, each independently selected from the group consisting of N, N(H), N(R d ), O, and S(O) 0-2 , wherein each of the heterocyclyl and heterocycloalkenyl is optionally substituted with 1-4 substituents independently selected from the group consisting of halo, C 1-4 alkyl, and C 1-4 haloalkyl;

heteroaryl of 5-10 ring atoms, wherein 1-4 ring atoms are heteroatoms, each independently selected from the group consisting of N, N(H), N(R d ), O, and S(O) 0-2 and wherein the heteroaryl ring is optionally substituted with 1-4 substituents independently selected from the group consisting of halo, C 1-4 alkyl, and C 1-4 haloalkyl; and

C 6-10 aryl, which is optionally substituted with 1-4 substituents independently selected from the group consisting of halo, C 1-4 alkyl, and C 1-4 haloalkyl;

-L 3 is —C 1-3 alkylene or a bond;

-L 4 is —O—, —N(H)—, —S(O) 0-2 —, or a bond;

each occurrence of R′ and R″ is independently selected from the group consisting of: H, —OH, C 1-4 alkyl, C 6-10 aryl optionally substituted with 1-2 substituents selected from the group consisting of halo, C 1-4 alkyl, and C 1-4 haloalkyl, and heteroaryl of 5-10 ring atoms, wherein 1-4 ring atoms are heteroatoms, each independently selected from the group consisting of N, N(H), N(R d ), O, and S(O) 0-2 and wherein the heteroaryl ring is optionally substituted with 1-4 substituents independently selected from the group consisting of halo, —OH, NH 2 , NH(C 1-4 alkyl), N(C 1-4 alkyl) 2 , C 1-4 alkyl, and C 1-4 haloalkyl; or R′ and R″ together with the nitrogen atom to which each is attached forms a ring of 3-8 ring atoms, wherein the ring has: (a) 1-7 ring carbon atoms, each of which is substituted with 1-2 substituents independently selected from the group consisting of H and C 1-3 alkyl; and (b) 0-3 ring heteroatoms (in addition to the nitrogen atom attached to R′ and R″), which are each independently selected from the group consisting of N(H), N(C 1-6 alkyl), O, and S; and

with the proviso that the compound is not

2 . The compound of claim 1 , wherein X 1 is NR 2 , such as: wherein X 1 is NH.

3 . The compound of claim 1 or 2 , wherein X 2 is CR 5 , such as: wherein X 2 is CH.

4 . The compound of any one of claims 1 - 3 , wherein the

moiety is

wherein one of R 1a and R 1b is R*, such as: wherein the

moiety is

5 . The compound of any one of claims 1 - 3 , wherein the compound is a compound of Formula (I-a1), (I-a2), (I-a3), or (I-a4):

such as:

wherein the compound is a compound of Formula (I-a2-1), (I-a1-1), or (I-a3-1):

and

optionally R 2 is H; and R 5 is H.

6 . The compound of any one of claims 1 - 5 , wherein R* is selected from the group consisting of:

heteroaryl of 5-10 ring atoms, wherein 1-4 ring atoms are heteroatoms, each independently selected from the group consisting of N, N(H), N(R d ), O, and S(O) 0-2 , and wherein the heteroaryl ring is optionally substituted with 1-4 independently selected R g ; and

C 6-10 aryl, which is optionally substituted with 1-4 independently selected R g .

7 . The compound of any one of claims 1 - 6 , wherein R* is heteroaryl of 5-10 ring atoms, wherein 1-4 ring atoms are heteroatoms, each independently selected from the group consisting of N, N(H), N(R d ), O, and S(O) 0-2 , and wherein the heteroaryl ring is optionally substituted with 1-4 independently selected R g ; such as:

wherein R* is heteroaryl of 5 ring atoms, wherein 1-4 ring atoms are heteroatoms, each independently selected from the group consisting of N, N(H), N(R d ), O, and S(O) 0-2 , and wherein the heteroaryl ring is optionally substituted with 1-4 independently selected R g ; or

wherein R* is heteroaryl of 6 ring atoms, wherein 1-4 ring atoms are heteroatoms, each independently selected from the group consisting of N, N(H), N(R d ), O, and S(O) 0-2 , and wherein the heteroaryl ring is optionally substituted with 1-4 independently selected R g .

8 . The compound of any one of claims 1 - 7 , wherein R* is C 6-10 aryl, which is optionally substituted with 1-4 independently selected R g .

9 . The compound of any one of claims 1 - 8 , wherein each occurrence of R** is independently selected from the group consisting of: H; halo, such as F; cyano; C 1-6 alkyl optionally substituted with 1-2 R a ; C 1-4 haloalkyl, such as CF 3 ; C 1-4 alkoxy; —NR e1 R f1 ; —OH; —S(O) 1-2 (NR′R″); —NO 2 ; —C(═O)(C 1-4 alkyl); —C(═O)O(C 1-4 alkyl); —C(═O)OH; and —C(═O)N(R′)(R″).

10 . The compound of any one of claims 1 - 9 , wherein W is selected from the group consisting of: C(═O); S(O) 2 ; C(═NR d ); C(═NH); C(═C—NO 2 ); S(O)N(R d ); and S(O)NH, such as: wherein W is C(═O).

11 . The compound of any one of claims 1 - 10 , wherein Q-A is defined according to (A), optionally wherein Q is NH.

12 . The compound of any one of claims 1 - 11 , wherein A is —(Y A1 ) n Y A2 .

13 . The compound of any one of claims 1 - 12 , wherein Y A2 is C 6-10 aryl, which is optionally substituted with 1-3 R c ; or

wherein Y A2 is heteroaryl of 5-14 ring atoms, wherein 1-3 ring atoms are heteroatoms, each independently selected from the group consisting of N, N(H), N(R d ), 0, and S(O) 0-2 , and wherein the heteroaryl ring is optionally substituted with 1-4 independently selected R c ; or

wherein Y A2 is C 3-20 cycloalkyl or C 3-20 cycloalkenyl, each of which is optionally substituted with 1-4 R b ; or

wherein Y A2 is heterocyclyl or heterocycloalkenyl, each of 3-16 ring atoms, wherein 1-3 ring atoms are heteroatoms, each independently selected from the group consisting of N, N(H), N(R d ), O, and S(O) 0-2 , and wherein each of the heterocyclyl and heterocycloalkenyl ring is optionally substituted with 1-3 independently selected R b .

14 . The compound of any one of claims 1 - 10 , wherein Q-A is as defined according to (B); and

E is a ring of 5-8 ring atoms, wherein 0-3 ring atoms are heteroatoms (in addition to the ring nitrogen atom that is present), each independently selected from the group consisting of N, N(H), N(R d ), O, and S(O) 0-2 , and wherein the ring is optionally substituted with 1-4 independently selected R b , such as: wherein E is

wherein R b is C 1-6 alkyl.

15 . The compound of claim 1 , wherein the compound is a compound of Formula (I-1), (I-2), (I-3), (I-4), (I-5), (I-6), (I-7), (I-8), or (I-9):

wherein W A is O, S, CHNO 2 , NR d , or NH; n1 is 0, 1, or 2; each of R cA and R cB is an independently selected R c ; and R 7 is H or C 1-4 alkyl;

wherein W A is O, S, CHNO 2 , NR d , or NH; n1 is 0, 1, or 2; each of R cA and R cB is an independently selected R c ; and R 7 is H or C 1-4 alkyl;

wherein W A is O, S, CHNO 2 , NR d , or NH; one of Q 1 and Q 2 is N; the other one of Q 1 and Q 2 is CH; n1 is 0, 1, or 2; each of R cA and R cB is an independently selected R c ; and R 7 is H or C 1-4 alkyl;

wherein W A is O, S, CHNO 2 , NR d , or NH; one of Q 1 , Q 2 , Q 3 , and Q 4 is N; each of the remaining of Q 1 , Q 2 , Q 3 , Q 4 is CH; n1 is 0, 1, or 2; and each of R cA and R cB is an independently selected R c ; and R 7 is H or C 1-4 alkyl;

wherein W A is O, S, CHNO 2 , NR d , or NH;

B 1 is selected from the group consisting of:

(a) bicyclic or tricyclic heteroaryl of 7-14 ring atoms, wherein 1-3 ring atoms are heteroatoms, each independently selected from the group consisting of N, N(H), N(R d ), 0, and S(O) 0-2 , and wherein the heteroaryl ring is optionally substituted with 1-4 independently selected R c ; and

(b) C 7-10 bicyclic aryl, which is optionally substituted with 1-3 R c ; and R 7 is H or C 1-4 alkyl;

wherein W A is O, S, CHNO 2 , NR d , or NH; n2 is 0, 1, or 2; each of R bA and R bB is an independently selected R b ; and R 7 is H or C 1-4 alkyl;

wherein W A is O, S, CHNO 2 , NR d , or NH; n2 is 0, 1, or 2; each of R bA and R bB is an independently selected R b ; and R 7 is H or C 1-4 alkyl;

wherein W A is O, S, CHNO 2 , NR d , or NH; B 2 is: bicyclic, tricyclic, or polycyclic C 7-20 cycloalkyl or C 7-20 cycloalkenyl, each optionally substituted with 1-2 R b ; and

R 7 is H or C 1-4 alkyl;

wherein E is a ring of 3-16 ring atoms, wherein aside from the nitrogen atom present, 0-3 additional ring atoms are heteroatoms, each independently selected from the group consisting of N, N(H), N(R d ), O, and S(O) 0-2 , and wherein the ring is optionally substituted with 1-4 independently selected R b ,

optionally X 1 is NH; and X 2 is CH in Formula (I-1), (I-2), (I-3), (I-4), (I-5), (I-6), (I-7), (I-8), or (I-9);

optionally W A is O in Formula (I-1), (I-2), (I-3), (I-4), (I-5), (I-6), (I-7), or (I-8);

optionally R cA is selected from the group consisting of: halo; cyano; C 1-10 alkyl which is optionally substituted with 1-6 independently selected R a ; C 2-6 alkenyl; C 2-6 alkynyl; C 1-4 alkoxy; C 1-4 haloalkoxy; —S(O) 1-2 (C 1-4 alkyl); —NR e R f ; —C 1-4 thioalkoxy; —C(═O)(C 1-10 alkyl); —C(═O)(OH); —C(═O)O(C 1-4 alkyl); and -L 1 -L 2 -R h in Formula (I-1), (I-2), (I-3), or (I-4);

optionally R bA is selected from the group consisting of C 1-10 alkyl which is substituted with 1-6 independently selected R a ; —F; —Cl; -L 1 -L 2 -R h ; C 1-4 alkoxy; and C 1-4 haloalkoxy in Formula (I-6) or (I-7); and

optionally one of R 1a and R 1b , such as R 1b , is R*; the other of R 1a and R 1b , such as R 1a , is R**, such as H or —F; and each of R c and R 1d is H.

16 . The compound of claim 1 , wherein the compound is selected from the group consisting of the compounds delineated in Table C1, or a pharmaceutically acceptable salt thereof.

17 . A pharmaceutical composition comprising a compound of claims 1 - 16 or a pharmaceutically acceptable salt thereof, and one or more pharmaceutically acceptable excipients.

18 . A method for inhibiting STING activity, the method comprising contacting STING with a compound as claimed in any one of claims 1 - 16 , or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition as claimed in claim 17 .

19 . A method of inducing an immune response in a subject in need thereof, the method comprising administering to the subject an effective amount of a compound as claimed in any one of claims 1 - 16 , or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition as claimed in claim 17 .

20 . A method of treatment of disease, disorder, or condition associated with STING, such as a disease, disorder, or condition, in which increased STING signaling, such as excessive STING signaling, contributes to the pathology and/or symptoms and/or progression of the disease, such as cancer, comprising administering to a subject in need of such treatment an effective amount of a compound as claimed in any one of claims 1 - 16 , or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition as claimed in claim 17 .