IP Library › Granted Patent US 12,528,826
Granted Patent B2
US 12,528,826 · App. 17/768,174 · Granted Jan 20, 2026

[1,4]oxazepino[2,3-c]quinolinone derivatives as BCL6 inhibitors

Inventors: Benjamin Richard Bellenie (London, GB); Alfie Brennan (London, GB); Kwai Ming Jack Cheung (London, GB); Owen Alexander Davis (London, GB); Alice Claire Harnden (London, GB); Swen Hoelder (London, GB); Rosemary Huckvale (London, GB)
Assignees: Cancer Research Technology Limited; The Institute of Cancer Research: Royal Cancer Hospital
C07D498/04A61K31/553A61K45/06C07D519/00
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Quick Facts
Patent No.
US 12,528,826
App. No.
17/768,174
Granted
Jan 20, 2026
Kind
B2
Abstract

The present invention relates to compounds that function as inhibitors of BCL6 (B-cell lymphoma 6) activity. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which BCL6 activity is implicated.

Claims (429)

1 . A compound, or a pharmaceutically acceptable salt or solvate thereof, selected from:

(S)-10-((5-chloro-2-(3,3-difluoroazetidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-(4-cyclopropyl-3-oxopiperazin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((S)-3,4-dimethyl-5-oxopiperazin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((2-hydroxy-2-methylpropyl)amino)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((2-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-5-chloropyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

N-((3S,5R)-1-(5-chloro-4-(((S)-2-cyclopropyl-3,3-difluoro-7-methyl-6-oxo-1,2,3,4,6,7-hexahydro-[1,4]oxazepino[2,3-c]quinolin-10-yl)amino)pyrimidin-2-yl)-5-methylpiperidin-3-yl) acetamide;

N-((3R,5S)-1-(5-chloro-4-(((S)-2-cyclopropyl-3,3-difluoro-7-methyl-6-oxo-1,2,3,4,6,7-hexahydro-[1,4]oxazepino[2,3-c]quinolin-10-yl)amino)pyrimidin-2-yl)-5-methylpiperidin-3-yl) acetamide;

(S)-10-((5-chloro-2-((3S,5R)-3-(dimethylamino)-5-methylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((S)-3-hydroxypiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((R)-3-hydroxypiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((S)-3-methylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((R)-3-methylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-(3-fluoro-3-methylazetidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-(3-hydroxy-3-methylazetidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-2-cyclopropyl-3,3-difluoro-10-((5-fluoro-2-((3R,5S)-3-hydroxy-5-methylpiperidin-1-yl)pyrimidin-4-yl)amino)-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-2-cyclopropyl-10-((2-(4,4-difluoropiperidin-1-yl)-5-fluoropyrimidin-4-yl)amino)-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((2-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-5-chloropyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-(methyl-d3)-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c][1,8]naphthyridin-6 (7H)-one;

(S)-10-((5-chloro-2-(3-methyl-1,2,4-oxadiazol-5-yl) pyridin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((3-chloro-2-fluoropyridin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-2-cyclopropyl-10-((2,3-dichloropyridin-4-yl)amino)-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((2-chloro-3-fluoropyridin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((3-chloro-2-methylpyridin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-2-cyclopropyl-3,3-difluoro-10-((5-fluoro-2-((1R,5S,7R)-7-hydroxy-3-oxa-9-azabicyclo[3.3.1]nonan-9-yl)pyrimidin-4-yl)amino)-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloropyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((2-(3-acetyl-3,8-diazabicyclo[3.2.1]octan-8-yl)-5-chloropyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((2-(8-acetyl-3,8-diazabicyclo[3.2.1]octan-3-yl)-5-chloropyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-(dimethylamino)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((3S,5R)-3-fluoro-5-hydroxypiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((3R,5S)-3-fluoro-5-hydroxypiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((S)-3-((dimethylamino)methyl) piperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(3R,5S)-1-(5-chloro-4-(((S)-2-cyclopropyl-3,3-difluoro-7-methyl-6-oxo-1,2,3,4,6,7-hexahydro-[1,4]oxazepino[2,3-c]quinolin-10-yl)amino)pyrimidin-2-yl)-N-ethyl-5-methylpiperidine-3-carboxamide;

(3S,5R)-1-(5-chloro-4-(((S)-2-cyclopropyl-3,3-difluoro-7-methyl-6-oxo-1,2,3,4,6,7-hexahydro-[1,4]oxazepino[2,3-c]quinolin-10-yl)amino)pyrimidin-2-yl)-N-ethyl-5-methylpiperidine-3-carboxamide;

(S)-10-((5-chloro-2-((3R,5S)-3-(hydroxymethyl)-5-methylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((3S,5R)-3-(hydroxymethyl)-5-methylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((R)-4,4-difluoro-3-hydroxypiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((S)-4,4-difluoro-3-hydroxypiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((R)-3-(fluoromethyl) piperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((S)-3-(fluoromethyl) piperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

2-((R)-1-(5-chloro-4-(((S)-2-cyclopropyl-3,3-difluoro-7-methyl-6-oxo-1,2,3,4,6,7-hexahydro-[1,4]oxazepino[2,3-c]quinolin-10-yl)amino)pyrimidin-2-yl) piperidin-3-yl) acetamide;

2-((S)-1-(5-chloro-4-(((S)-2-cyclopropyl-3,3-difluoro-7-methyl-6-oxo-1,2,3,4,6,7-hexahydro-[1,4]oxazepino[2,3-c]quinolin-10-yl)amino)pyrimidin-2-yl) piperidin-3-yl) acetamide;

(S)-10-((5-chloro-2-((S)-3-(dimethylamino) piperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((R)-3-(dimethylamino) piperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(R)-1-(5-chloro-4-(((S)-2-cyclopropyl-3,3-difluoro-7-methyl-6-oxo-1,2,3,4,6,7-hexahydro-[1,4]oxazepino[2,3-c]quinolin-10-yl)amino)pyrimidin-2-yl)-N-ethyl-4,4-difluoropiperidine-3-carboxamide;

(S)-1-(5-chloro-4-(((S)-2-cyclopropyl-3,3-difluoro-7-methyl-6-oxo-1,2,3,4,6,7-hexahydro-[1,4]oxazepino[2,3-c]quinolin-10-yl)amino)pyrimidin-2-yl)-N-ethyl-4,4-difluoropiperidine-3-carboxamide;

N-(((R)-1-(5-chloro-4-(((S)-2-cyclopropyl-3,3-difluoro-7-methyl-6-oxo-1,2,3,4,6,7-hexahydro-[1,4]oxazepino[2,3-c]quinolin-10-yl)amino)pyrimidin-2-yl)-4,4-difluoropiperidin-3-yl)methyl)-N-ethylacetamide;

N-(((S)-1-(5-chloro-4-(((S)-2-cyclopropyl-3,3-difluoro-7-methyl-6-oxo-1,2,3,4,6,7-hexahydro-[1,4]oxazepino[2,3-c]quinolin-10-yl)amino)pyrimidin-2-yl)-4,4-difluoropiperidin-3-yl)methyl)-N-ethylacetamide;

(S)-10-((5-chloro-2-((1R,4R)-5,5-difluoro-2-azabicyclo[2.2.1]heptan-2-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((1S,4S)-5,5-difluoro-2-azabicyclo[2.2.1]heptan-2-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

N-((R)-1-(5-chloro-4-(((S)-2-cyclopropyl-3,3-difluoro-7-methyl-6-oxo-1,2,3,4,6,7-hexahydro-[1,4]oxazepino[2,3-c]quinolin-10-yl)amino)pyrimidin-2-yl)-4,4-difluoropiperidin-3-yl)-N-methylacetamide;

N-((S)-1-(5-chloro-4-(((S)-2-cyclopropyl-3,3-difluoro-7-methyl-6-oxo-1,2,3,4,6,7-hexahydro-[1,4]oxazepino[2,3-c]quinolin-10-yl)amino)pyrimidin-2-yl)-4,4-difluoropiperidin-3-yl)-N-methylacetamide;

(S)-10-((5-chloro-2-(4-fluoro-4-(hydroxymethyl) piperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((R)-3-(hydroxymethyl) piperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((S)-3-(hydroxymethyl) piperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((1S,5R)-3-ethyl-2-oxo-3,8-diazabicyclo[3.2.1]octan-8-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((1R,5S)-3-ethyl-2-oxo-3,8-diazabicyclo[3.2.1]octan-8-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((3S,5R)-3,5-difluoropiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((2-(6-acetyl-2,6-diazaspiro[3.3]heptan-2-yl)-5-chloropyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((2-hydroxy-2-methylpropyl)(methyl)amino)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((3-hydroxy-3-methylbutyl)(methyl)amino)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-(6-(cyclopropylmethyl)-2,6-diazaspiro[3.3]heptan-2-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((5-chloro-2-(6-((2,2-difluorocyclopropyl)methyl)-2,6-diazaspiro[3.3]heptan-2-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((5-chloro-2-(8-(cyclopropylmethyl)-3,8-diazabicyclo[3.2.1]octan-3-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((5-chloro-2-(8-((2,2-difluorocyclopropyl)methyl)-3,8-diazabicyclo[3.2.1]octan-3-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((3R,5R)-3-hydroxy-5-methylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((3S,4R)-3,4-difluoropiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((3R,4S)-3,4-difluoropiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((3S,4S)-3,4-difluoropiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((3R,4R)-3,4-difluoropiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((R)-3-methoxypiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((S)-3-methoxypiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-fluoro-2-((3S,4R)-3,4-difluoropiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-fluoro-2-((3R,4S)-3,4-difluoropiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-[[5-chloro-2-(4-methyl-1,4-diazepan-1-yl)pyrimidin-4-yl]amino]-2-cyclopropyl-3,3-difluoro-7-methyl-2,4-dihydro-1H-[1,4]oxazepino[2,3-c]quinolin-6-one;

(S)-10-((5-chloro-2-((R)-3-ethylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((S)-3-ethylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((R)-3-methylazepan-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((S)-3-methylazepan-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((R)-4-methylazepan-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((S)-4-methylazepan-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((3R,5S)-3,5-dihydroxypiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((1R,5R)-1-(hydroxymethyl)-5-methyl-3-azabicyclo[3.1.0]hexan-3-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((1S,5S)-1-(hydroxymethyl)-5-methyl-3-azabicyclo[3.1.0]hexan-3-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((3R,5R)-3-fluoro-5-hydroxypiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((3S,5S)-3-fluoro-5-hydroxypiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((R)-7-hydroxy-5-azaspiro[2.5]octan-5-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((S)-7-hydroxy-5-azaspiro[2.5]octan-5-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-(methyl(propyl)amino)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((3R,4S)-3-(hydroxymethyl)-4-methylpyrrolidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((3S,4R)-3-(hydroxymethyl)-4-methylpyrrolidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((2-hydroxyethyl) (propyl)amino)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-(5-azaspiro[2.5]octan-5-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-(((R)-3-methoxy-2-methylpropyl)amino)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-(((S)-3-methoxy-2-methylpropyl)amino)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-(3,3-dimethylazetidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-(3-methylazetidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-1-(5-chloro-4-((2-cyclopropyl-3,3-difluoro-7-methyl-6-oxo-1,2,3,4,6,7-hexahydro-[1,4]oxazepino[2,3-c]quinolin-10-yl)amino)pyrimidin-2-yl) azetidine-3-carbonitrile;

(S)-10-((5-chloro-2-(3-fluoroazetidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((R)-3-(difluoromethyl) piperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((S)-3-(difluoromethyl) piperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-1-(5-chloro-4-((2-cyclopropyl-3,3-difluoro-7-methyl-6-oxo-1,2,3,4,6,7-hexahydro-[1,4]oxazepino[2,3-c]quinolin-10-yl)amino)pyrimidin-2-yl)-3-methylazetidine-3-carbonitrile;

(S)-2-(1-(5-chloro-4-((2-cyclopropyl-3,3-difluoro-7-methyl-6-oxo-1,2,3,4,6,7-hexahydro-[1,4]oxazepino[2,3-c]quinolin-10-yl)amino)pyrimidin-2-yl) azetidin-3-yl) acetonitrile;

(S)-10-((5-chloro-2-(3-(difluoromethyl) azetidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((2-(azetidin-1-yl)-5-chloropyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-(3-methoxyazetidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-(3-methoxy-3-methylazetidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((R)-3-ethylpyrrolidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((S)-3-ethylpyrrolidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((R)-3-fluoro-3-methylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((S)-3-fluoro-3-methylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((R)-3-hydroxy-3-methylpyrrolidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((S)-3-hydroxy-3-methylpyrrolidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((2-((3S,5R)-3-amino-5-methylpiperidin-1-yl)-5-chloropyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((2-((3R,5S)-3-amino-5-methylpiperidin-1-yl)-5-chloropyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((2-(6-oxa-3-azabicyclo[3.1.1]heptan-3-yl)-5-chloropyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((R)-3,3-difluoro-5-hydroxypiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((S)-3,3-difluoro-5-hydroxypiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((R)-2-methylthiomorpholino)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((S)-2-methylthiomorpholino)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((R)-4,6-dimethyl-1,4-diazepan-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((S)-4,6-dimethyl-1,4-diazepan-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((S)-hexahydropyrrolo[1,2-a]pyrazin-2 (1H)-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((R)-hexahydropyrrolo[1,2-a]pyrazin-2 (1H)-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((R)-6-oxohexahydropyrrolo[1,2-a]pyrazin-2 (1H)-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((S)-6-oxohexahydropyrrolo[1,2-a]pyrazin-2 (1H)-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((R)-8-hydroxy-6-azaspiro[3.5]nonan-6-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((S)-8-hydroxy-6-azaspiro[3.5]nonan-6-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((3R,5S)-3-hydroxy-5-methylpiperidin-1-yl) pyridin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

((S)-10-((5-chloro-2-(4,4-difluoropiperidin-1-yl) pyridin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((S)-4,4-difluoro-3-methylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((R)-4,4-difluoro-3-methylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((R)-4,4-difluoro-3-methylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((S)-4,4-difluoro-3-methylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((S)-3-methylpyrrolidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((R)-3-methylpyrrolidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((3R,5S)-3-fluoro-5-methylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((3R,5S)-3-methoxy-5-methylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((5-chloro-2-(2,6-dimethylthiomorpholino)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((5-chloro-2-(3,4-dimethylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((5-chloro-2-(2,3-dimethylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((5-chloro-2-(2,6-dimethyl-1-oxidothiomorpholino)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((2R,5S)-2-(hydroxymethyl)-5-methylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((5-chloro-2-(2,6-dimethyl-1,1-dioxidothiomorpholino)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((5-chloro-2-(2,5-dimethylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((3S,5S)-3-hydroxy-5-methylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((5-chloro-2-(6-hydroxy-1,4-diazepan-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((2-(3-(2-(azetidin-1-yl)-2-oxoethyl)-5-methylpiperidin-1-yl)-5-chloropyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((2-((3S,5R)-3-(2-(azetidin-1-yl)-2-oxoethyl)-5-methylpiperidin-1-yl)-5-chloropyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((2-((3R,5S)-3-(2-(azetidin-1-yl)-2-oxoethyl)-5-methylpiperidin-1-yl)-5-chloropyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((5-chloro-2-(3-(2-(3,3-difluoroazetidin-1-yl)-2-oxoethyl)-5-methylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((5-chloro-2-((3R,5S)-3-(2-(3,3-difluoroazetidin-1-yl)-2-oxoethyl)-5-methylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((5-chloro-2-((3S,5R)-3-(2-(3,3-difluoroazetidin-1-yl)-2-oxoethyl)-5-methylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((2-(3-(azetidine-1-carbonyl)-4,4-difluoropiperidin-1-yl)-5-chloropyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((5-chloro-2-(3-(3,3-difluoroazetidine-1-carbonyl)-4,4-difluoropiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((5-chloro-2-(3-(2-(3,3-difluoroazetidin-1-yl)-2-oxoethyl)-4,4-difluoropiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((2-(3-(2-(azetidin-1-yl)-2-oxoethyl)-4,4-difluoropiperidin-1-yl)-5-chloropyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((5-chloro-2-(3-ethynylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

1-(5-chloro-4-(((S)-2-cyclopropyl-3,3-difluoro-7-methyl-6-oxo-1,2,3,4,6,7-hexahydro-[1,4]oxazepino[2,3-c]quinolin-10-yl)amino)pyrimidin-2-yl) piperidine-3-carbonitrile;

(S)-10-((5-chloro-2-((4,4-difluorocyclohexyl)amino)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((2-(2-azabicyclo[4.1.0]heptan-2-yl)-5-chloropyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((5-chloro-2-(3-(difluoromethyl) piperazin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((3R,5S)-3-(2-(dimethylamino) ethoxy)-5-methylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((2-(3-(azetidine-1-carbonyl)-5-methylpiperidin-1-yl)-5-chloropyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((5-chloro-2-(3-(3,3-difluoroazetidine-1-carbonyl)-5-methylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-(3-(hydroxymethyl) azetidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((5-chloro-2-(2-(hydroxymethyl) azetidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((S)-2-(hydroxymethyl) azetidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((R)-2-(hydroxymethyl) azetidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-(3-(fluoromethyl) azetidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((5-chloro-2-(2-methylazetidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-1-(5-chloro-4-((2-cyclopropyl-3,3-difluoro-7-methyl-6-oxo-1,2,3,4,6,7-hexahydro-[1,4]oxazepino[2,3-c]quinolin-10-yl)amino)pyrimidin-2-yl) piperidine-4-carbonitrile;

1-(5-chloro-4-(((S)-2-cyclopropyl-3,3-difluoro-7-methyl-6-oxo-1,2,3,4,6,7-hexahydro-[1,4]oxazepino[2,3-c]quinolin-10-yl)amino)pyrimidin-2-yl)-5-fluoro-N,N-dimethylpiperidine-3-carboxamide;

(2S)-10-((5-chloro-2-(3-fluoropiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-(4-fluoropiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((S)-2-(hydroxymethyl) pyrrolidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((5-chloro-2-(2-(methoxymethyl) pyrrolidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((S)-2-(methoxymethyl) pyrrolidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((R)-2-(methoxymethyl) pyrrolidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((5-chloro-2-(2-(hydroxymethyl)-3-methylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((S)-4,4-difluoro-2-(hydroxymethyl) pyrrolidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((5-chloro-2-(4-fluoro-2-(hydroxymethyl) pyrrolidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((2S,4S)-4-fluoro-2-(hydroxymethyl) pyrrolidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((2S,4R)-4-fluoro-2-(hydroxymethyl) pyrrolidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((5-chloro-2-(2-(hydroxymethyl)-3-methylpyrrolidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((5-chloro-2-(4,4-difluoro-2-(hydroxymethyl) piperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-2-cyclopropyl-10-((2-(4,4-difluoro-3,5-dimethylpiperidin-1-yl)-5-fluoropyrimidin-4-yl)amino)-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-2-cyclopropyl-3,3-difluoro-10-((5-fluoro-2-morpholinopyrimidin-4-yl)amino)-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-2-cyclopropyl-3,3-difluoro-10-((5-fluoro-2-((S)-2-methylmorpholino)pyrimidin-4-yl)amino)-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((2-((1R,5S)-8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-5-fluoropyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-2-cyclopropyl-10-((2-(dimethylamino)-5-fluoropyrimidin-4-yl)amino)-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-2-cyclopropyl-10-((2-(dimethylamino)-5-chloropyridin-4-yl)amino)-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-2-cyclopropyl-10-((2-(4,4-difluoropiperidin-1-yl)-5-fluoropyridin-4-yl)amino)-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-2-cyclopropyl-3,3-difluoro-10-((5-fluoro-2-((3R,5S)-3-hydroxy-5-methylpiperidin-1-yl) pyridin-4-yl)amino)-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((3S,5R)-3-fluoro-5-methylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((5-chloro-2-(6-hydroxy-4-methyl-1,4-diazepan-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((5-chloro-2-(3-methyl-5-oxopiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((3R,5S)-3-(3-(dimethylamino) propoxy)-5-methylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((5-chloro-2-(2-(fluoromethyl) azetidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((5-chloro-2-(4,4-difluoro-3-methoxypiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((5-chloro-2-(4,4-difluoro-3-hydroxy-5-methylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-2-cyclopropyl-10-((2-(4,4-difluoro-3-methylpiperidin-1-yl)-5-fluoropyrimidin-4-yl)amino)-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-2-cyclopropyl-3,3-difluoro-10-((5-fluoro-2-((R)-2-methylmorpholino)pyrimidin-4-yl)amino)-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((2-(6-oxa-3-azabicyclo[3.1.1]heptan-3-yl)-5-fluoropyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-2-cyclopropyl-10-((2-(4,4-difluoro-3-(hydroxymethyl) piperidin-1-yl)-5-fluoropyrimidin-4-yl)amino)-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-2-cyclopropyl-10-((2-(4,4-difluoro-3,5-dimethylpiperidin-1-yl)-5-chloropyridin-4-yl)amino)-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-2-cyclopropyl-10-((2-(4,4-difluoro-3-methylpiperidin-1-yl)-5-chloropyridin-4-yl)amino)-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-2-cyclopropyl-10-((2-(3,4-difluoropiperidin-1-yl)-5-chloropyridin-4-yl)amino)-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-2-cyclopropyl-3,3-difluoro-10-((5-chloro-2-morpholinopyridin-4-yl)amino)-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-2-cyclopropyl-3,3-difluoro-10-((5-chloro-2-((R)-2-methylmorpholino)pyridin-4-yl)amino)-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-2-cyclopropyl-3,3-difluoro-10-((5-chloro-2-((S)-methylmorpholino)pyridin-4-yl)amino)-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((2-(6-oxa-3-azabicyclo[3.1.1]heptan-3-yl)-5-chloropyridin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((2-((1R,5S)-3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-5-chloropyridin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((2-((1R,5S)-8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-5-chloropyridin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-2-cyclopropyl-10-((2-(4,4-difluoro-3-(hydroxymethyl) piperidin-1-yl)-5-chloropyridin-4-yl)amino)-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-2-cyclopropyl-10-((2-(4,4-difluoro-3,5-dimethylpiperidin-1-yl)-5-fluoropyridin-4-yl)amino)-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-2-cyclopropyl-10-((2-(4,4-difluoro-3-methylpiperidin-1-yl)-5-fluoropyridin-4-yl)amino)-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-2-cyclopropyl-10-((2-(3,4-difluoropiperidin-1-yl)-5-fluoropyridin-4-yl)amino)-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-2-cyclopropyl-3,3-difluoro-10-((5-fluoro-2-morpholinopyridin-4-yl)amino)-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-2-cyclopropyl-3,3-difluoro-10-((5-fluoro-2-((R)-2-methylmorpholino)pyridin-4-yl)amino)-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-2-cyclopropyl-3,3-difluoro-10-((5-fluoro-2-((S)-2-methylmorpholino)pyridin-4-yl)amino)-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((2-(6-oxa-3-azabicyclo[3.1.1]heptan-3-yl)-5-fluoropyridin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((2-((1R,5S)-3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-5-fluoropyridin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((2-((1R,5S)-8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-5-fluoropyridin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-2-cyclopropyl-10-((2-(dimethylamino)-5-fluoropyridin-4-yl)amino)-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one; or

(2S)-2-cyclopropyl-10-((2-(4,4-difluoro-3-(hydroxymethyl) piperidin-1-yl)-5-fluoropyridin-4-yl)amino)-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one.

2 . A compound, or a pharmaceutically acceptable salt or solvate thereof, according to claim 1 selected from:

(S)-10-((5-chloro-2-(3,3-difluoroazetidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-(4-cyclopropyl-3-oxopiperazin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((S)-3,4-dimethyl-5-oxopiperazin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((2-hydroxy-2-methylpropyl)amino)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((2-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-5-chloropyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

N-((3S,5R)-1-(5-chloro-4-(((S)-2-cyclopropyl-3,3-difluoro-7-methyl-6-oxo-1,2,3,4,6,7-hexahydro-[1,4]oxazepino[2,3-c]quinolin-10-yl)amino)pyrimidin-2-yl)-5-methylpiperidin-3-yl) acetamide;

N-((3R,5S)-1-(5-chloro-4-(((S)-2-cyclopropyl-3,3-difluoro-7-methyl-6-oxo-1,2,3,4,6,7-hexahydro-[1,4]oxazepino[2,3-c]quinolin-10-yl)amino)pyrimidin-2-yl)-5-methylpiperidin-3-yl) acetamide;

(S)-10-((5-chloro-2-((3S,5R)-3-(dimethylamino)-5-methylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((S)-3-hydroxypiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((R)-3-hydroxypiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((S)-3-methylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((R)-3-methylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-(3-fluoro-3-methylazetidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-(3-hydroxy-3-methylazetidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-2-cyclopropyl-3,3-difluoro-10-((5-fluoro-2-((3R,5S)-3-hydroxy-5-methylpiperidin-1-yl)pyrimidin-4-yl)amino)-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-2-cyclopropyl-10-((2-(4,4-difluoropiperidin-1-yl)-5-fluoropyrimidin-4-yl)amino)-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((2-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-5-chloropyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-(methyl-d3)-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c][1,8]naphthyridin-6 (7H)-one;

(S)-10-((5-chloro-2-(3-methyl-1,2,4-oxadiazol-5-yl) pyridin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((3-chloro-2-fluoropyridin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-2-cyclopropyl-10-((2,3-dichloropyridin-4-yl)amino)-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((2-chloro-3-fluoropyridin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((3-chloro-2-methylpyridin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-2-cyclopropyl-3,3-difluoro-10-((5-fluoro-2-((1R,5S,7R)-7-hydroxy-3-oxa-9-azabicyclo[3.3.1]nonan-9-yl)pyrimidin-4-yl)amino)-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloropyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((2-(3-acetyl-3,8-diazabicyclo[3.2.1]octan-8-yl)-5-chloropyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((2-(8-acetyl-3,8-diazabicyclo[3.2.1]octan-3-yl)-5-chloropyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-(dimethylamino)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((3S,5R)-3-fluoro-5-hydroxypiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((3R,5S)-3-fluoro-5-hydroxypiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((S)-3-((dimethylamino)methyl) piperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(3R,5S)-1-(5-chloro-4-(((S)-2-cyclopropyl-3,3-difluoro-7-methyl-6-oxo-1,2,3,4,6,7-hexahydro-[1,4]oxazepino[2,3-c]quinolin-10-yl)amino)pyrimidin-2-yl)-N-ethyl-5-methylpiperidine-3-carboxamide;

(3S,5R)-1-(5-chloro-4-(((S)-2-cyclopropyl-3,3-difluoro-7-methyl-6-oxo-1,2,3,4,6,7-hexahydro-[1,4]oxazepino[2,3-c]quinolin-10-yl)amino)pyrimidin-2-yl)-N-ethyl-5-methylpiperidine-3-carboxamide;

(S)-10-((5-chloro-2-((3R,5S)-3-(hydroxymethyl)-5-methylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((3S,5R)-3-(hydroxymethyl)-5-methylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((R)-4,4-difluoro-3-hydroxypiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((S)-4,4-difluoro-3-hydroxypiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((R)-3-(fluoromethyl) piperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((S)-3-(fluoromethyl) piperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

2-((R)-1-(5-chloro-4-(((S)-2-cyclopropyl-3,3-difluoro-7-methyl-6-oxo-1,2,3,4,6,7-hexahydro-[1,4]oxazepino[2,3-c]quinolin-10-yl)amino)pyrimidin-2-yl) piperidin-3-yl) acetamide;

2-((S)-1-(5-chloro-4-(((S)-2-cyclopropyl-3,3-difluoro-7-methyl-6-oxo-1,2,3,4,6,7-hexahydro-[1,4]oxazepino[2,3-c]quinolin-10-yl)amino)pyrimidin-2-yl) piperidin-3-yl) acetamide;

(S)-10-((5-chloro-2-((S)-3-(dimethylamino) piperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((R)-3-(dimethylamino) piperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(R)-1-(5-chloro-4-(((S)-2-cyclopropyl-3,3-difluoro-7-methyl-6-oxo-1,2,3,4,6,7-hexahydro-[1,4]oxazepino[2,3-c]quinolin-10-yl)amino)pyrimidin-2-yl)-N-ethyl-4,4-difluoropiperidine-3-carboxamide;

(S)-1-(5-chloro-4-(((S)-2-cyclopropyl-3,3-difluoro-7-methyl-6-oxo-1,2,3,4,6,7-hexahydro-[1,4]oxazepino[2,3-c]quinolin-10-yl)amino)pyrimidin-2-yl)-N-ethyl-4,4-difluoropiperidine-3-carboxamide;

N-(((R)-1-(5-chloro-4-(((S)-2-cyclopropyl-3,3-difluoro-7-methyl-6-oxo-1,2,3,4,6,7-hexahydro-[1,4]oxazepino[2,3-c]quinolin-10-yl)amino)pyrimidin-2-yl)-4,4-difluoropiperidin-3-yl)methyl)-N-ethylacetamide;

N-(((S)-1-(5-chloro-4-(((S)-2-cyclopropyl-3,3-difluoro-7-methyl-6-oxo-1,2,3,4,6,7-hexahydro-[1,4]oxazepino[2,3-c]quinolin-10-yl)amino)pyrimidin-2-yl)-4,4-difluoropiperidin-3-yl)methyl)-N-ethylacetamide;

(S)-10-((5-chloro-2-((1R,4R)-5,5-difluoro-2-azabicyclo[2.2.1]heptan-2-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((1S,4S)-5,5-difluoro-2-azabicyclo[2.2.1]heptan-2-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

N-((R)-1-(5-chloro-4-(((S)-2-cyclopropyl-3,3-difluoro-7-methyl-6-oxo-1,2,3,4,6,7-hexahydro-[1,4]oxazepino[2,3-c]quinolin-10-yl)amino)pyrimidin-2-yl)-4,4-difluoropiperidin-3-yl)-N-methylacetamide;

N-((S)-1-(5-chloro-4-(((S)-2-cyclopropyl-3,3-difluoro-7-methyl-6-oxo-1,2,3,4,6,7-hexahydro-[1,4]oxazepino[2,3-c]quinolin-10-yl)amino)pyrimidin-2-yl)-4,4-difluoropiperidin-3-yl)-N-methylacetamide;

(S)-10-((5-chloro-2-(4-fluoro-4-(hydroxymethyl) piperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((R)-3-(hydroxymethyl) piperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((S)-3-(hydroxymethyl) piperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((1S,5R)-3-ethyl-2-oxo-3,8-diazabicyclo[3.2.1]octan-8-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((1R,5S)-3-ethyl-2-oxo-3,8-diazabicyclo[3.2.1]octan-8-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((3S,5R)-3,5-difluoropiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((2-(6-acetyl-2,6-diazaspiro[3.3]heptan-2-yl)-5-chloropyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((2-hydroxy-2-methylpropyl)(methyl)amino)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((3-hydroxy-3-methylbutyl)(methyl)amino)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-(6-(cyclopropylmethyl)-2,6-diazaspiro[3.3]heptan-2-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((5-chloro-2-(6-((2,2-difluorocyclopropyl)methyl)-2,6-diazaspiro[3.3]heptan-2-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((5-chloro-2-(8-(cyclopropylmethyl)-3,8-diazabicyclo[3.2.1]octan-3-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((5-chloro-2-(8-((2,2-difluorocyclopropyl)methyl)-3,8-diazabicyclo[3.2.1]octan-3-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((3R,5R)-3-hydroxy-5-methylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((3S,4R)-3,4-difluoropiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((3R,4S)-3,4-difluoropiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((3S,4S)-3,4-difluoropiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((3R,4R)-3,4-difluoropiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((R)-3-methoxypiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((S)-3-methoxypiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-fluoro-2-((3S,4R)-3,4-difluoropiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-fluoro-2-((3R,4S)-3,4-difluoropiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-[[5-chloro-2-(4-methyl-1,4-diazepan-1-yl)pyrimidin-4-yl]amino]-2-cyclopropyl-3,3-difluoro-7-methyl-2,4-dihydro-1H-[1,4]oxazepino[2,3-c]quinolin-6-one;

(S)-10-((5-chloro-2-((R)-3-ethylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((S)-3-ethylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((R)-3-methylazepan-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((S)-3-methylazepan-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((R)-4-methylazepan-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((S)-4-methylazepan-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((3R,5S)-3,5-dihydroxypiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((1R,5R)-1-(hydroxymethyl)-5-methyl-3-azabicyclo[3.1.0]hexan-3-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((1S,5S)-1-(hydroxymethyl)-5-methyl-3-azabicyclo[3.1.0]hexan-3-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((3R,5R)-3-fluoro-5-hydroxypiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((3S,5S)-3-fluoro-5-hydroxypiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((R)-7-hydroxy-5-azaspiro[2.5]octan-5-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((S)-7-hydroxy-5-azaspiro[2.5]octan-5-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-(methyl(propyl)amino)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((3R,4S)-3-(hydroxymethyl)-4-methylpyrrolidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((3S,4R)-3-(hydroxymethyl)-4-methylpyrrolidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((2-hydroxyethyl) (propyl)amino)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-(5-azaspiro[2.5]octan-5-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-(((R)-3-methoxy-2-methylpropyl)amino)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-(((S)-3-methoxy-2-methylpropyl)amino)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-(3,3-dimethylazetidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-(3-methylazetidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-1-(5-chloro-4-((2-cyclopropyl-3,3-difluoro-7-methyl-6-oxo-1,2,3,4,6,7-hexahydro-[1,4]oxazepino[2,3-c]quinolin-10-yl)amino)pyrimidin-2-yl) azetidine-3-carbonitrile;

(S)-10-((5-chloro-2-(3-fluoroazetidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((R)-3-(difluoromethyl) piperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((S)-3-(difluoromethyl) piperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-1-(5-chloro-4-((2-cyclopropyl-3,3-difluoro-7-methyl-6-oxo-1,2,3,4,6,7-hexahydro-[1,4]oxazepino[2,3-c]quinolin-10-yl)amino)pyrimidin-2-yl)-3-methylazetidine-3-carbonitrile;

(S)-2-(1-(5-chloro-4-((2-cyclopropyl-3,3-difluoro-7-methyl-6-oxo-1,2,3,4,6,7-hexahydro-[1,4]oxazepino[2,3-c]quinolin-10-yl)amino)pyrimidin-2-yl) azetidin-3-yl) acetonitrile;

(S)-10-((5-chloro-2-(3-(difluoromethyl) azetidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((2-(azetidin-1-yl)-5-chloropyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-(3-methoxyazetidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-(3-methoxy-3-methylazetidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((R)-3-ethylpyrrolidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((S)-3-ethylpyrrolidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((R)-3-fluoro-3-methylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((S)-3-fluoro-3-methylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((R)-3-hydroxy-3-methylpyrrolidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((S)-3-hydroxy-3-methylpyrrolidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((2-((3S,5R)-3-amino-5-methylpiperidin-1-yl)-5-chloropyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((2-((3R,5S)-3-amino-5-methylpiperidin-1-yl)-5-chloropyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((2-(6-oxa-3-azabicyclo[3.1.1]heptan-3-yl)-5-chloropyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((R)-3,3-difluoro-5-hydroxypiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((S)-3,3-difluoro-5-hydroxypiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((R)-2-methylthiomorpholino)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((S)-2-methylthiomorpholino)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((R)-4,6-dimethyl-1,4-diazepan-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((S)-4,6-dimethyl-1,4-diazepan-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((S)-hexahydropyrrolo[1,2-a]pyrazin-2 (1H)-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((R)-hexahydropyrrolo[1,2-a]pyrazin-2 (1H)-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((R)-6-oxohexahydropyrrolo[1,2-a]pyrazin-2 (1H)-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((S)-6-oxohexahydropyrrolo[1,2-a]pyrazin-2 (1H)-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((R)-8-hydroxy-6-azaspiro[3.5]nonan-6-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((S)-8-hydroxy-6-azaspiro[3.5]nonan-6-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((3R,5S)-3-hydroxy-5-methylpiperidin-1-yl) pyridin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

((S)-10-((5-chloro-2-(4,4-difluoropiperidin-1-yl) pyridin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((S)-4,4-difluoro-3-methylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((R)-4,4-difluoro-3-methylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((R)-4,4-difluoro-3-methylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((S)-4,4-difluoro-3-methylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((S)-3-methylpyrrolidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((R)-3-methylpyrrolidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((3R,5S)-3-fluoro-5-methylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((3R,5S)-3-methoxy-5-methylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((5-chloro-2-(2,6-dimethylthiomorpholino)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((5-chloro-2-(3,4-dimethylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((5-chloro-2-(2,3-dimethylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((5-chloro-2-(2,6-dimethyl-1-oxidothiomorpholino)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((2R,5S)-2-(hydroxymethyl)-5-methylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((5-chloro-2-(2,6-dimethyl-1,1-dioxidothiomorpholino)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((5-chloro-2-(2,5-dimethylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((3S,5S)-3-hydroxy-5-methylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((5-chloro-2-(6-hydroxy-1,4-diazepan-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((2-(3-(2-(azetidin-1-yl)-2-oxoethyl)-5-methylpiperidin-1-yl)-5-chloropyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((2-((3S,5R)-3-(2-(azetidin-1-yl)-2-oxoethyl)-5-methylpiperidin-1-yl)-5-chloropyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((2-((3R,5S)-3-(2-(azetidin-1-yl)-2-oxoethyl)-5-methylpiperidin-1-yl)-5-chloropyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((5-chloro-2-(3-(2-(3,3-difluoroazetidin-1-yl)-2-oxoethyl)-5-methylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((5-chloro-2-((3R,5S)-3-(2-(3,3-difluoroazetidin-1-yl)-2-oxoethyl)-5-methylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((5-chloro-2-((3S,5R)-3-(2-(3,3-difluoroazetidin-1-yl)-2-oxoethyl)-5-methylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((2-(3-(azetidine-1-carbonyl)-4,4-difluoropiperidin-1-yl)-5-chloropyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((5-chloro-2-(3-(3,3-difluoroazetidine-1-carbonyl)-4,4-difluoropiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((5-chloro-2-(3-(2-(3,3-difluoroazetidin-1-yl)-2-oxoethyl)-4,4-difluoropiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((2-(3-(2-(azetidin-1-yl)-2-oxoethyl)-4,4-difluoropiperidin-1-yl)-5-chloropyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((5-chloro-2-(3-ethynylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

1-(5-chloro-4-(((S)-2-cyclopropyl-3,3-difluoro-7-methyl-6-oxo-1,2,3,4,6,7-hexahydro-[1,4]oxazepino[2,3-c]quinolin-10-yl)amino)pyrimidin-2-yl) piperidine-3-carbonitrile;

(S)-10-((5-chloro-2-((4,4-difluorocyclohexyl)amino)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((2-(2-azabicyclo[4.1.0]heptan-2-yl)-5-chloropyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((5-chloro-2-(3-(difluoromethyl) piperazin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((3R,5S)-3-(2-(dimethylamino) ethoxy)-5-methylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((2-(3-(azetidine-1-carbonyl)-5-methylpiperidin-1-yl)-5-chloropyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((5-chloro-2-(3-(3,3-difluoroazetidine-1-carbonyl)-5-methylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-(3-(hydroxymethyl) azetidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((5-chloro-2-(2-(hydroxymethyl) azetidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((S)-2-(hydroxymethyl) azetidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((R)-2-(hydroxymethyl) azetidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-(3-(fluoromethyl) azetidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((5-chloro-2-(2-methylazetidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-1-(5-chloro-4-((2-cyclopropyl-3,3-difluoro-7-methyl-6-oxo-1,2,3,4,6,7-hexahydro-[1,4]oxazepino[2,3-c]quinolin-10-yl)amino)pyrimidin-2-yl) piperidine-4-carbonitrile;

1-(5-chloro-4-(((S)-2-cyclopropyl-3,3-difluoro-7-methyl-6-oxo-1,2,3,4,6,7-hexahydro-[1,4]oxazepino[2,3-c]quinolin-10-yl)amino)pyrimidin-2-yl)-5-fluoro-N,N-dimethylpiperidine-3-carboxamide;

(2S)-10-((5-chloro-2-(3-fluoropiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-(4-fluoropiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((S)-2-(hydroxymethyl) pyrrolidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((5-chloro-2-(2-(methoxymethyl) pyrrolidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((S)-2-(methoxymethyl) pyrrolidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((R)-2-(methoxymethyl) pyrrolidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((5-chloro-2-(2-(hydroxymethyl)-3-methylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((S)-4,4-difluoro-2-(hydroxymethyl) pyrrolidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((5-chloro-2-(4-fluoro-2-(hydroxymethyl) pyrrolidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((2S,4S)-4-fluoro-2-(hydroxymethyl) pyrrolidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((5-chloro-2-((2S,4R)-4-fluoro-2-(hydroxymethyl) pyrrolidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((5-chloro-2-(2-(hydroxymethyl)-3-methylpyrrolidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-10-((5-chloro-2-(4,4-difluoro-2-(hydroxymethyl) piperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(2S)-2-cyclopropyl-10-((2-(4,4-difluoro-3,5-dimethylpiperidin-1-yl)-5-fluoropyrimidin-4-yl)amino)-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-2-cyclopropyl-3,3-difluoro-10-((5-fluoro-2-morpholinopyrimidin-4-yl)amino)-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-2-cyclopropyl-3,3-difluoro-10-((5-fluoro-2-((S)-2-methylmorpholino)pyrimidin-4-yl)amino)-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-10-((2-((1R,5S)-8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-5-fluoropyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-2-cyclopropyl-10-((2-(dimethylamino)-5-fluoropyrimidin-4-yl)amino)-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-2-cyclopropyl-10-((2-(dimethylamino)-5-chloropyridin-4-yl)amino)-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-2-cyclopropyl-3,3-difluoro-10-((5-chloro-2-morpholinopyridin-4-yl)amino)-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-2-cyclopropyl-3,3-difluoro-10-((5-chloro-2-((S)-methylmorpholino)pyridin-4-yl)amino)-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one;

(S)-2-cyclopropyl-10-((2-(4,4-difluoropiperidin-1-yl)-5-fluoropyridin-4-yl)amino)-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one; or(S)-2-cyclopropyl-3,3-difluoro-10-((5-fluoro-2-((3R,5S)-3-hydroxy-5-methylpiperidin-1-yl) pyridin-4-yl)amino)-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6 (7H)-one.

3 . A pharmaceutical composition comprising a compound according to claim 1 , or a pharmaceutically acceptable salt or solvate thereof, and a pharmaceutically acceptable carrier or excipient.

4 . A method of treating a disease comprising:

administering a therapeutically effective amount of a pharmaceutical according to claim 3 to a subject in need of such treatment.

5 . The method according to claim 4 , wherein the disease is selected from cancer, HIV, sepsis, graft-versus-host disease, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, or auto-immune diseases.

6 . The method of claim 4 , wherein the disease is cancer and further comprising administering an additional therapeutic agent.

7 . The method of claim 6 , wherein the additional therapeutic agent is selected from a BCL-2 family inhibitor, a BTK inhibitor, a TNF inhibitor, an EZH2 inhibitor, a HDAC inhibitor, an ATR kinase inhibitor, an ATM kinase inhibitor, an EGFR tyrosine kinase inhibitor, or a corticosteroid.

8 . The method of claim 5 , wherein the cancer is selected from diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), Burkitt lymphoma (BL), angioimmunoblastic T-cell lymphoma (AITL), acute lymphoblastic leukaemia (ALL), acute myeloid leukaemia (AML), chronic myeloid leukaemia (CML), multiple myeloma, breast cancer, non-small cell lung cancer (NSCLC) or squamous cell carcinomas (SCC) of the head and neck, oesophagus, lung or ovary.

9 . A method of treating a subject having cancer comprising:

administering an effective amount of a compound according to claim 2 , or a pharmaceutically acceptable salt or solvate thereof, and a pharmaceutically acceptable carrier or excipient.

10 . The method of claim 9 , wherein the cancer is selected from diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), Burkitt lymphoma (BL), angioimmunoblastic T-cell lymphoma (AITL), acute lymphoblastic leukaemia (ALL), acute myeloid leukaemia (AML), chronic myeloid leukaemia (CML), multiple myeloma, breast cancer, non-small cell lung cancer (NSCLC) or squamous cell carcinomas (SCC) of the head and neck, oesophagus, lung or ovary.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 9, 2025
From: BELLENIE, BENJAMIN RICHARD; BRENNAN, ALFIE; CHEUNG, KWAI MING JACK; DAVIS, OWEN ALEXANDER; HARNDEN, ALICE CLAIRE; HOELDER, SWEN; HUCKVALE, ROSEMARY
To: THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL; CANCER RESEARCH TECHNOLOGY LIMITED
Reel/Frame 071646/0715 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 30, 2022
From: BELLENIE, BENJAMIN RICHARD; BRENNAN, ALFIE; CHEUNG, KWAI MING JACK; HARNDEN, ALICE CLAIRE; HOELDER, SWEN; DAVIS, OWEN ALEXANDER; HUCKVALE, ROSEMARY
To: THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL
Reel/Frame 060938/0213 →
Priority Claims (1)
GB 1914860 · Oct 14, 2019 · national
Continuity (1)
Related Publication 20240217987A1 · Jul 4, 2024
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