CAL-T CONSTRUCTS AND USES THEREOF
The technology described herein is directed to compositions comprising components of multi-component CALs or CARs, e.g., a TCR recognition domain; and one or both of: (a) an intracellular signaling domain; and (b) a first-type protein interaction domain. Further provided herein are methods for treating or preventing an autoimmune disease, a transplant rejection, or graft versus host disease.
1 - 65 . (canceled)
66 . A method of treating or preventing an autoimmune disease or condition; T cell mediated inflammation or immune response; malignant T cell condition; transplant rejection; or GvHD in a subject in need thereof, the method comprising administering to the subject
a. a soluble extracellular molecule or soluble extracellular complex comprising:
a TCR recognition domain that binds specifically to a variable region of a TCR, and
a first biomolecular interaction domain of a binding pair of biomolecular interaction domains; and
b. an engineered cell expressing or comprising an engineered signaling polypeptide comprising a second biomolecular interaction domain of the binding pair of biomolecular interaction domains and an intracellular signaling domain.