IP Library › Granted Patent US 12,540,131

Granted Patent B2

US 12,540,131 · App. 17/769,814 · Granted Feb 3, 2026

N-(heteroaryl) quinazolin-2-amine derivatives as LRRK2 inhibitors, pharmaceutical compositions, and uses thereof

Inventors: Mitchell H. Keylor (Malden, MA); Michael J. Ardolino (Arlington, MA); Ryan W. Chau (Somerville, MA); Peter H. Fuller (Ashland, MA); Anmol Gulati (Watertown, MA); Rebecca Elizabeth Johnson (Oakland, CA); Solomon D. Kattar (Wakefield, MA); Kaila A. Margrey (Cambridge, MA); Gregori J. Morriello (Randolph, NJ); Santhosh F. Neelamkavil (Edison, NJ); Xin Yan (Newton, MA); Elsie C. Yu (Brighton, MA); Cayetana Carmela Zarate Saez (Boston, MA)

Assignee: Merck Sharp & Dohme LLC

C07D403/14 C07D401/14 C07D403/12 C07D405/14 C07D409/14 C07D413/14 C07D417/14

View Patent ↗

Loading inventors, assignments & file history…

Monitor This Case

Get email alerts when status or documents change.

Order Certified Copies

Most orders are placed with the USPTO same day — all within 24 business hours.

Order via The Patent Place →

Pre-filled with this patent's details

Quick Facts

Patent No.: US 12,540,131
App. No.: 17/769,814
Granted: Feb 3, 2026
Kind: B2

External Links

USPTO Patent Center↗ Full Patent PDF↗

Abstract

The present invention is directed to substituted certain N-(heteroaryl)quinazolin-2-amine derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein J, R 3 , and R 4 , are as defined herein, which are potent inhibitors of LRRK2 kinase and may be useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease and other diseases and disorders described herein. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of diseases, such as Parkinson's disease, in which LRRK-2 kinase is involved.

Claims (2213)

1 . A compound represented by structural Formula I:

or a pharmaceutically acceptable salt thereof, wherein:

J is selected from:

R 1 is independently selected from H, —(C 1 -C 6 )alkyl, —(C 1 -C 6 )haloalkyl, halogen, CN, and cyclopropyl;

R 2 is independently selected from —(C 1 -C 6 )alkyl, —(C 1 -C 6 )haloalkyl, —((C 1 -C 6 )alkyl)) n (C 3 -C 8 )cycloalkyl, bicyclopentanyl, spiroheptanyl, azaspiroheptanyl, (CH 2 ) n oxetanyl, (CH 2 ) n oxolanyl, thiazolyl, and piperidinyl, said alkyl, haloalkyl, cycloalkyl, and bicyclopentanyl optionally substituted with 1, 2, or 3 groups independently selected from halogen, OH, CN, —(C 1 -C 6 )alkyl, —(C 1 -C 6 )alkylOH, O-(C 1 -C 6 )alkyl, —(C 1 -C 6 )alkyl-O-(C 1 -C 6 )alkyl, and -O-(C 1 -C 6 )haloalkyl, and said spiroheptanyl, azaspiroheptanyl, oxetanyl, oxolanyl, thiazolyl, and piperidinyl optionally substituted with 1 to 2 groups independently selected from halogen, OH, CN, —(C 1 -C 6 )alkyl, —(CH 2 ) n O(C 1 -C 6 )alkyl, —(C 1 -C 6 )haloalkyl, oxolanyl, and oxetanyl, said oxolanyl and oxetanyl optionally substituted with 1 to 2 groups of CH 3 ;

R 3 is selected from CH 3 , CF 3 , OCH 3 , Cl, CN, and cyclopropyl; and

R 4 is selected from (C 3 -C 6 )cycloalkyl, piperidinyl, pyrrolidinyl, spiropentanyl, spirohexanyl, azaspiroheptanyl, azabicycloheptanyl, azabicylcooctanyl, and oxaazabicyclononanyl, said cycloalkyl, piperidinyl, pyrrolidinyl, spiropentanyl, spirohexanyl, azaspiroheptanyl, azabicycloheptanyl, azabicylcooctanyl, and oxaazabicyclononanyl optionally substituted with 1 to 3 groups of R b ,

R b is selected from hydrogen, (C 1 -C 6 )alkyl, OH, (CH 2 ) n (C 3 -C 6 )cycloalkyl, halogen, (C 1 -C 6 )haloalkyl, C(O)(C 1 -C 6 )alkyl, (CH 2 ) n oxetanyl, (CH 2 ) n oxolanyl, (CH 2 ) n oxanyl, tetrahydrothiophenedionyl, thietanedionyl, oxaspirooctanyl, and bicyclohexanyl, said alkyl, cycloalkyl, oxetanyl, oxolanyl, tetrahydrothiophenedionyl, thietanedionyl, oxaspirooctanyl, and bicyclohexanyl optionally substituted with 1 to 3 groups of R b1 ;

R b1 is selected from (C 1 -C 6 )alkyl, O(C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl, OH, halogen, CN, CF 3 , phenyl, oxazolidinonyl, pyrrolidinonyl, and morpholinyl, said phenyl and alkyl optionally substituted with 1 to 2 groups of halogen and CN; and

n is 0, 1, 2, 3, or 4.

2 . A compound, or a pharmaceutically acceptable salt thereof represented by structural Formula I′:

wherein X is N and Y is C, or X is C and Y is S,

such that the moiety

is selected from

R 1 S

R 1 is selected from H, Cl, and CH 3 ;

R 2 is selected from —(C 1 -C 6 )alkyl, —(C 1 -C 6 )haloalkyl, —(C 1 -C 6 )alkyl-OH, -(C 1 -C 6 ) haloalkyl-OH, —(C 1 -C 6 )alkyl-CN, —(C 1 -C 6 )alkyl-O-(C 1 -C 6 )alkyl, —(C 1 -C 6 )alkyl-O-(C 1 -C 6 ) haloalkyl,

—(C 3 -C 6 )cycloalkyl,

—(C 3 -C 6 )cycloalkyl which is substituted with 1, 2, or 3 groups independently selected from halogen, OH, CN, —(C 1 -C 6 )alkyl, and -O-(C 1 -C 6 )alkyl,

—(C 1 -C 3 )alkyl (C 3 -C 6 )cycloalkyl,

—(C 1 -C 3 )alkyl (C 3 -C 6 )cycloalkyl which is substituted with 1, 2, or 3 groups independently selected from halogen, OH, CN, and —(C 1 -C 6 )alkyl,

bicycloalkyl;

bicycloalkyl which is substituted with 1 or 2 groups independently selected from halogen, C(O)(C 1 -C 6 )alkyl, C(O) O(C 1 -C 6 )alkyl, (C 1 -C 6 )alkyl-OH, (C 1 -C 6 )alkyl-CN, C(O) NH (C 1 -C 6 )alkyl, C(O) N ((C 1 -C 6 )alkyl) 2 , C(O) N ((C 1 -C 6 )alkyl)-O-((C 1 -C 6 )alkyl), (C 1 -C 6 )haloalkyl, (C 1 -C 6 )alkyl-O-(C 1 -C 6 )alkyl, (C 1 -C 6 )haloalkyl-O-(C 1 -C 6 )alkyl, (C 1 -C 6 )alkyl-O-(C 1 -C 6 )haloalkyl, (C 1 -C 6 )haloalkyl-O-(C 1 -C 6 )haloalkyl, cyclopropyl, and cyclobutyl;

oxetanyl,

oxetanyl which is substituted with 1, 2, or 3 groups independently selected from halogen, OH, CN, and —(C 1 -C 6 )alkyl,

tetrahydrofuranyl,

tetrahydrofuranyl which is substituted with 1, 2, or 3 groups independently selected from halogen, OH, CN, and —(C 1 -C 6 )alkyl,

—(C 1 -C 3 )alkyl-oxetanyl,

—(C 1 -C 3 )alkyl-oxetanyl which is substituted with 1, 2, or 3 groups independently selected from halogen, OH, CN, and —(C 1 -C 6 )alkyl,

—(C 1 -C 3 )alkyl-tetrahydrofuranyl,

—(C 1 -C 3 )alkyl-tetrahydrofuranyl which is substituted with 1, 2, or 3 groups independently selected from halogen, OH, CN, and —(C 1 -C 6 )alkyl,

wherein R 2E is selected from H, —(C 1 -C 6 )alkyl, —(C 1 -C 6 )haloalkyl,

wherein:

R 2F is selected from H, —(C 1 -C 6 )alkyl, —(C 1 -C 6 ) fluoroalkyl, —(C 1 -C 6 )alkyl-O-(C 1 -C 6 )alkyl,

R 3 is selected from CH 3 , CF 3 , OCH 3 , Cl, CN, and cyclopropyl; and

R 4 is selected from (C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl, (C 3 -C 6 )cycloalkyl substituted with 1 or 2 fluorine atoms,

wherein:

q is 1 or 2;

R a is selected from H, F, and OH;

R c is selected from H, F, CN, OH, —(C 1 -C 6 )alkyl, and O(C 1 -C 4 )alkyl;

R b is selected from H, —(C 1 -C 6 )alkyl, —(C 1 -C 6 )haloalkyl, —(C 1 -C 6 )alkyl-OH, —(C 1 -C 6 )alkyl-CN, —(C 1 -C 6 )haloalkyl-OH, —(C 1 -C 6 )alkyl-O-(C 1 -C 6 )alkyl, —(C 1 -C 6 )alkyl-O-(C 1 -C 6 )haloalkyl, -(C 3 -C 6 )cycloalkyl,

—(C 3 -C 6 )cycloalkyl which is substituted with 1, 2, or 3 groups independently selected from halogen, OH, CN, (C 1 -C 6 )alkyl, and O(C 1 -C 4 )alkyl,

—(C 1 -C 3 )alkyl (C 3 -C 6 )cycloalkyl,

—(C 1 -C 3 )alkyl (C 3 -C 6 )cycloalkyl which is substituted with 1, 2, or 3 groups independently selected from halogen, OH, CN, and —(C 1 -C 6 )alkyl,

oxetanyl,

oxetanyl which is substituted with 1, 2, or 3 groups independently selected from halogen, OH, CN, and —(C 1 -C 6 )alkyl,

—(C 1 -C 3 )alkyl-oxetanyl,

—(C 1 -C 3 )alkyl-oxetanyl which is substituted with 1, 2, or 3 groups independently selected from halogen, OH, CN, and —(C 1 -C 6 )alkyl,

tetrahydrofuranyl,

tetrahydrofuranyl which is substituted with 1, 2, or 3 groups independently selected from halogen, OH, CN, and —(C 1 -C 6 )alkyl,

—(C 1 -C 3 )alkyl-tetrahydrofuranyl,

—(C 1 -C 3 )alkyl-tetrahydrofuranyl which is substituted with 1, 2, or 3 groups independently selected from halogen, OH, CN, and —(C 1 -C 6 )alkyl,

thietanyl,

thietanyl which is substituted with 1, 2, or 3 groups independently selected from halogen, OH, CN, and —(C 1 -C 6 )alkyl,

—(C 1 -C 3 )alkyl-thietanyl,

—(C 1 -C 3 )alkyl-thietanyl which is substituted with 1, 2, or 3 groups independently selected from halogen, OH, CN, and —(C 1 -C 6 )alkyl,

thietanyl 1,1-dioxide,

thietanyl 1,1-dioxide which is substituted with 1, 2, or 3 groups independently selected from halogen, OH, CN, and —(C 1 -C 6 )alkyl,

—(C 1 -C 3 )alkyl-thietanyl 1,1-dioxide,

—(C 1 -C 3 )alkyl-thietanyl 1,1-dioxide which is substituted with 1, 2, or 3 groups independently selected from halogen, OH, CN, and —(C 1 -C 6 )alkyl,

tetrahydrothiophenyl,

tetrahydrothiophenyl which is substituted with 1, 2, or 3 groups independently selected from halogen, OH, CN, and —(C 1 -C 6 )alkyl,

—(C 1 -C 3 )alkyl-tetrahydrothiophenyl,

—(C 1 -C 3 )alkyl-tetrahydrothiophenyl which is substituted with 1, 2, or 3 groups independently selected from halogen, OH, CN, and —(C 1 -C 6 )alkyl,

tetrahydrothiophenyl 1,1-dioxide,

tetrahydrothiophenyl 1,1-dioxide which is substituted with 1, 2, or 3 groups independently selected from halogen, OH, CN, and —(C 1 -C 6 )alkyl,

—(C 1 -C 3 )alkyl-tetrahydrothiophenyl 1,1-dioxide, and

—(C 1 -C 3 )alkyl-tetrahydrothiophenyl 1,1-dioxide which is substituted with 1, 2, or 3 groups independently selected from halogen, OH, CN, and —(C 1 -C 6 )alkyl.

3 . The compound according to claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 3 is selected from Cl, CH 3 , and CN.

4 . The compound according to claim 1 , or a pharmaceutically acceptable salt thereof, wherein J is selected from:

5 . The compound according to claim 1 , or a pharmaceutically acceptable salt thereof, wherein J is selected from:

R 1 is selected from H, Cl, and CH 3 ; and R 2 is independently selected from —(C 1 -C 6 )alkyl, -(C 1 -C 6 ) haloalkyl, —(C 1 -C 6 )alkyl-O-(C 1 -C 6 )alkyl, (CH 2 ) n cyclopropyl, (CH 2 ) n cyclobutyl, bicyclopentanyl, spiroheptanyl, azaspiroheptanyl, (CH 2 ) n oxetanyl, (CH 2 ) n oxolanyl, thiazolyl, and piperidinyl, said alkyl, haloalkyl, cycloalkyl, and bicyclopentanyl optionally substituted with 1, 2, or 3 groups independently selected from halogen, OH, CN, —(C 1 -C 6 )alkyl, —(C 1 -C 6 )alkylOH, O-(C 1 -C 6 )alkyl, —(C 1 -C 6 )alkyl-O-(C 1 -C 6 )alkyl, and -O-(C 1 -C 6 )haloalkyl, said spiroheptanyl, azaspiroheptanyl, oxetanyl, oxolanyl, thiazolyl, and piperidinyl optionally substituted with 1 or 2 groups independently selected from halogen, OH, CN, —(C 1 -C 6 )alkyl, -(CH 2 ) n O(C 1 -C 6 )alkyl, -(C 1 -C 6 )haloalkyl, oxolanyl, and oxetanyl, said oxolanyl and oxetanyl optionally substituted with 1 to 2 groups of CH 3 .

6 . The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein J is

R 1 is selected from H, Cl, and CH 3 ; and R 2 is independently selected from —(C 1 -C 6 )alkyl, —(C 1 -C 6 )haloalkyl, —(C 1 -C 6 )alkyl-O-(C 1 -C 6 )alkyl, (CH 2 ) n cyclopropyl, (CH 2 ) n cyclobutyl, bicyclopentanyl, spiroheptanyl, azaspiroheptanyl, (CH 2 ) n oxetanyl, (CH 2 ) n oxolanyl, thiazolyl, and piperidinyl, said alkyl, haloalkyl, cycloalkyl, and bicyclopentanyl optionally substituted with 1, 2, or 3 groups independently selected from halogen, OH, CN, —(C 1 -C 6 )alkyl, —(C 1 -C 6 )alkylOH, O-(C 1 -C 6 )alkyl, —(C 1 -C 6 )alkyl-O-(C 1 -C 6 )alkyl, and -O-(C 1 -C 6 )haloalkyl, said spiroheptanyl, azaspiroheptanyl, oxetanyl, oxolanyl, thiazolyl, and piperidinyl optionally substituted with 1 to 2 groups independently selected from halogen, OH, CN, —(C 1 -C 6 )alkyl, -(CH 2 ) n O(C 1 -C 6 )alkyl, —(C 1 -C 6 )haloalkyl, oxolanyl, and oxetanyl, said oxolanyl and oxetanyl optionally substituted with 1 to 2 groups of CH 3 .

7 . The compound according to claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 4 is selected from cyclopropyl, cyclohexyl, azaspiroheptanyl, spiropentanyl, spirohexanyl, azabicycloheptanyl, azabicyclooctanyl, oxaazabicyclononanyl, pyrrolidinyl, and piperidinyl, said cyclopropyl, cyclohexyl, azaspiroheptanyl, spiropentanyl, spirohexanyl, azabicycloheptanyl, azabicyclooctanyl, oxaazabicyclononanyl, pyrrolidinyl, and piperidinyl optionally substituted with 1 to 3 groups selected from (C 1 -C 6 )alkyl, OH, (CH 2 ) n (C 3 -C 6 )cycloalkyl, halogen, (C 1 -C 6 )haloalkyl, C(O)(C 1 -C 6 )alkyl, (CH 2 ) n oxetanyl, (CH 2 ) n oxolanyl, (CH 2 ) n oxanyl, tetrahydrothiophenedionyl, thietanedionyl, oxaspirooctanyl, and bicyclohexanyl, said alkyl, cycloalkyl, oxetanyl, oxolanyl, tetrahydrothiophenedionyl, thietanedionyl, oxaspirooctanyl, and bicyclohexanyl optionally substituted with 1 to 3 groups selected from CH 3 , OH, OCH 3 , CF 3 , Fl, Cl, CN, CH 2 CN, and cyclopropyl.

8 . The compound according to claim 1 wherein R 4 is selected from azaspiroheptanyl, spiropentanyl, spirohexanyl, azabicycloheptanyl, azabicyclooctanyl, oxaazabicyclononanyl, pyrrolidinyl, and piperidinyl said azaspiroheptanyl, spiropentanyl, spirohexanyl, azabicycloheptanyl, azabicyclooctanyl, and oxaazabicyclononanyl, pyrrolidinyl, and piperidinyl optionally substituted with 1 to 3 groups selected from CH 3 , CH 2 C(CH 3 ) 2 OH, oxetanyl, oxolanyl, and thietanedionyl, said oxetanyl, oxolanyl, and thietanedionyl optionally substituted with 1 to 3 groups selected from CH 3 , OH, OCH 3 , CF 3 , Fl, Cl, CN, CH 2 CN, and cyclopropyl.

9 . The compound according to claim 1 wherein R 4 is selected from pyrrolidinyl, and piperidinyl, said pyrrolidinyl, and piperidinyl optionally substituted with 1 to 3 groups selected from CH 3 , CH 2 C(CH 3 ) 2 OH, oxetanyl, oxolanyl, and thietanedionyl, said oxetanyl, oxolanyl, and thietanedionyl optionally substituted with 1 to 3 groups selected from CH 3 , OH, OCH 3 , CF 3 , Fl, Cl, CN, CH 2 CN, and cyclopropyl.

10 . The compound according to claim 1 represented by structural Formula II:

or a pharmaceutically acceptable salt thereof, wherein J, R 3 , and R b are as described and R b2 is independently selected from C 1-6 alkyl and halogen.

11 . The compound according to claim 10 wherein R b2 is independently selected from C 1-6 alkyl and halogen, R 3 is selected from Cl, CH 3 , CF 3 , and CN, and J is selected from:

12 . The compound according to claim 10 wherein R 1 is selected from H, -CH 3 , -C(CH 3 ) 3 , -CHF 2 , CF 3 , Br, Cl, CN, and cyclopropyl, and R 2 is selected from —(C 1 -C 6 )alkyl, —(C 1 -C 6 )haloalkyl, —(C 1 -C 6 )alkyl-O-(C 1 -C 6 )alkyl, (CH 2 ) n cyclopropyl, (CH 2 ) n cyclobutyl, bicyclopentanyl, spiroheptanyl, azaspiroheptanyl, (CH 2 ) n oxetanyl, (CH 2 ) n oxolanyl, thiazolyl, and piperidinyl, said alkyl, haloalkyl, cycloalkyl, and bicyclopentanyl optionally substituted with 1, 2, or 3 groups independently selected from halogen, OH, CN, —(C 1 -C 6 )alkyl, —(C 1 -C 6 )alkylOH, O-(C 1 -C 6 )alkyl, —(C 1 -C 6 )alkyl-O-(C 1 -C 6 )alkyl, and -O-(C 1 -C 6 ) haloalkyl, said spiroheptanyl, azaspiroheptanyl, oxetanyl, oxolanyl, thiazolyl, and piperidinyl optionally substituted with 1 to 2 groups independently selected from halogen, OH, CN, —(C 1 -C 6 )alkyl, -(CH 2 ) n O(C 1 -C 6 )alkyl, —(C 1 -C 6 )haloalkyl, oxolanyl, and oxetanyl, said oxolanyl and oxetanyl optionally substituted with 1 to 2 groups of CH 3 , wherein n is 0-3.

13 . The compound according to claim 10 wherein R b is selected from CH 3 , CH 2 C(CH 3 ) 2 OH, oxetanyl, oxolanyl, and thietanedionyl, said oxetanyl, oxolanyl, and thietanedionyl optionally substituted with 1 to 3 groups of R b1 selected from CH 3 , OH, OCH 3 , CF 3 , Fl, Cl, CN, CH 2 CN, and cyclopropyl.

14 . The compound of claim 1 , or a pharmaceutically acceptable salt thereof selected from:

(S) 6-chloro-N-(1-ethyl-5-methyl-1H-pyrazol-4-yl)-7-(spiro[2.2]pentan-1-yl)quinazolin-2-

amine

(R) 6-chloro-N-(1-ethyl-5-methyl-1H-pyrazol-4-yl)-7-(spiro[2.2]pentan-1-yl)quinazolin-2-

amine

(S) 1-(3-(6-chloro-2-((1-cyclopropyl-1H-pyrazol-4-yl)amino)quinazolin-7-yl)pyrrolidin-1-

yl)-2-methylpropan-2-ol

(R) 1-(3-(6-chloro-2-((1-cyclopropyl-1H-pyrazol-4-yl)amino)quinazolin-7-yl)pyrrolidin-1-

yl)-2-methylpropan-2-ol

(1R,2S) 2-(4-(6-chloro-2-((1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino)quinazolin-7-

yl)piperidin-1-yl)cyclobutan-1-ol

(1R,2R) 2-(4-(6-chloro-2-((1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino)quinazolin-7-

yl)piperidin-1-yl)cyclobutan-1-ol

(1S,2S) 2-(4-(6-chloro-2-((1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino)quinazolin-7-

yl)piperidin-1-yl)cyclobutan-1-ol

(1S,2R) 2-(4-(6-chloro-2-((1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino)quinazolin-7-

yl)piperidin-1-yl)cyclobutan-1-ol

(3R,4R)-4-(4-(6-chloro-2-((5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino)quinazolin-7-

yl)piperidin-1-yl)-4-methyltetrahydrofuran-3-ol

(3S,4S)-4-(4-(6-chloro-2-((5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino)quinazolin-7-

yl)piperidin-1-yl)-4-methyltetrahydrofuran-3-ol

(S) 1-(3-{6-chloro-2-[(1-cyclopropyl-1H-pyrazol-4-yl)amino]quinazolin-7-yl}pyrrolidin-1-

yl)-2-methylpropan-2-ol

(R) 1-(3-{6-chloro-2-[(1-cyclopropyl-1H-pyrazol-4-yl)amino]quinazolin-7-yl}pyrrolidin-1-

yl)-2-methylpropan-2-ol

(S) 6-chloro-N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-(2-methyl-1-(oxetan-3-

yl)piperidin-4-yl)quinazolin-2-amine

(R) 6-chloro-N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-(2-methyl-1-(oxetan-3-

yl)piperidin-4-yl)quinazolin-2-amine

(S) 6-chloro-N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-(2-methyl-1-(oxetan-3-

yl)piperidin-4-yl)quinazolin-2-amine

(R) 6-chloro-N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-(2-methyl-1-(oxetan-3-

yl)piperidin-4-yl)quinazolin-2-amine

(S) 6-chloro-N-(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)-7-(2-methyl-1-(oxetan-3-

yl)piperidin-4-yl)quinazolin-2-amine

(R) 6-chloro-N-(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)-7-(2-methyl-1-(oxetan-3-

yl)piperidin-4-yl)quinazolin-2-amine

(S) 6-chloro-N-(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)-7-(2-methyl-1-(oxetan-3-

yl)piperidin-4-yl)quinazolin-2-amine

(R) 6-chloro-N-(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)-7-(2-methyl-1-(oxetan-3-

yl)piperidin-4-yl)quinazolin-2-amine

(3S,4S) 4-(4-(6-chloro-2-((1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino)quinazolin-7-

yl)piperidin-1-yl)-4-methyltetrahydrofuran-3-ol

(3R,4R) 4-(4-(6-chloro-2-((1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino)quinazolin-7-

yl)piperidin-1-yl)-4-methyltetrahydrofuran-3-ol

(3S,4S) 4-(4-(6-chloro-2-((1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino)quinazolin-7-

yl)piperidin-1-yl)-4-methyltetrahydrofuran-3-ol

(3R,4R) 4-(4-(6-chloro-2-((1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino)quinazolin-7-

yl)piperidin-1-yl)-4-methyltetrahydrofuran-3-ol

cis or trans-4-(6-chloro-2-((5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino)quinazolin-7-

yl)-1-methylcyclohexan-1-ol

cis or trans-4-(6-chloro-2-((1-cyclopropyl-1H-pyrazol-4-yl)amino)quinazolin-7-yl)-1-

methylcyclohexan-1-ol

(1R,2S) 2-(4-(6-chloro-2-((1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino)quinazolin-7-

yl)piperidin-1-yl)-2-methylcyclopentan-1-ol

(1S,2R) 2-(4-(6-chloro-2-((1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino)quinazolin-7-

yl)piperidin-1-yl)-2-methylcyclopentan-1-ol

(1S,2S) 2-(4-(6-chloro-2-((1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino)quinazolin-7-

yl)piperidin-1-yl)-2-methylcyclopentan-1-ol

(1R,2R) 2-(4-(6-chloro-2-((1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino)quinazolin-7-

yl)piperidin-1-yl)-2-methylcyclopentan-1-ol

(S) 6-chloro-N-(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)-7-[1-(2,2-

difluorocyclopentyl)piperidin-4-yl]quinazolin-2-amine

(R) 6-chloro-N-(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)-7-[1-(2,2-

difluorocyclopentyl)piperidin-4-yl]quinazolin-2-amine

(3S,4S) 4-(4-{6-chloro-2-[(3-cyclopropyl-1-methyl-1H-pyrazol-5-yl)amino]quinazolin-7-

yl}piperidin-1-yl)oxolan-3-ol

(3R,4R) 4-(4-{6-chloro-2-[(3-cyclopropyl-1-methyl-1H-pyrazol-5-yl)amino]quinazolin-7-

yl}piperidin-1-yl)oxolan-3-ol

(3S,4S) 4-[4-(6-chloro-2-{[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-

yl]amino}quinazolin-7-yl)piperidin-1-yl]oxolan-3-ol

(3R,4R) 4-[4-(6-chloro-2-{[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-

yl]amino}quinazolin-7-yl)piperidin-1-yl]oxolan-3-ol

(3S,4S) 4-(4-{6-chloro-2-[(1,3-dimethyl-1H-pyrazol-5-yl)amino]quinazolin-7-yl}piperidin-

1-yl)-4-methyloxolan-3-ol

(3R,4R) 4-(4-{6-chloro-2-[(1,3-dimethyl-1H-pyrazol-5-yl)amino]quinazolin-7-yl}piperidin-

1-yl)-4-methyloxolan-3-ol

(3S,4S)-4-(4-(6-chloro-2-((5-methyl-1-(methyl-d3)-1H-pyrazol-4-yl)amino)quinazolin-7-

yl)piperidin-1-yl)-4-methyltetrahydrofuran-3-ol

(3R,4R)-4-(4-(6-chloro-2-((5-methyl-1-(methyl-d3)-1H-pyrazol-4-yl)amino)quinazolin-7-

yl)piperidin-1-yl)-4-methyltetrahydrofuran-3-ol

(3S,4S)-4-(4-(6-chloro-2-((5-chloro-1-(methyl-d3)-1H-pyrazol-4-yl)amino)quinazolin-7-

yl)piperidin-1-yl)-4-methyltetrahydrofuran-3-ol

(3R,4R)-4-(4-(6-chloro-2-((5-chloro-1-(methyl-d3)-1H-pyrazol-4-yl)amino)quinazolin-7-

yl)piperidin-1-yl)-4-methyltetrahydrofuran-3-ol

(3S,4S) 4-(4-{6-chloro-2-[(1-cyclopropyl-3-methyl-1H-pyrazol-5-yl)amino]quinazolin-7-

yl}piperidin-1-yl)-4-methyloxolan-3-ol

(3R,4R) 4-(4-{6-chloro-2-[(1-cyclopropyl-3-methyl-1H-pyrazol-5-yl)amino]quinazolin-7-

yl}piperidin-1-yl)-4-methyloxolan-3-ol

(3S,4S) 1-(5-chloro-4-((6-chloro-7-(3-fluoro-1-(3-methyloxetan-3-yl)piperidin-4-

yl)quinazolin-2-yl)amino)-1H-pyrazol-1-yl)-2-methylpropan-2-ol

(3R,4R) 1-(5-chloro-4-((6-chloro-7-(3-fluoro-1-(3-methyloxetan-3-yl)piperidin-4-

yl)quinazolin-2-yl)amino)-1H-pyrazol-1-yl)-2-methylpropan-2-ol

6-chloro-N-(1-(3-(methoxymethyl)bicyclo[1.1.1]pentan-1-yl)-1H-pyrazol-4-yl)-7-(1-(3-

methyloxetan-3-yl)piperidin-4-yl)quinazolin-2-amine

(3S,4S)-(4-(4-(2-((5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino)-6-methylquinazolin-7-

yl)piperidin-1-yl)tetrahydrofuran-3-ol

(3R,4R)-(4-(4-(2-((5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino)-6-methylquinazolin-7-

yl)piperidin-1-yl)tetrahydrofuran-3-ol

(S) 6-chloro-N-{1-[1-(3-methyloxetan-3-yl)piperidin-4-yl]-1H-pyrazol-4-yl}-7-

(spiro[2.2]pentan-1-yl)quinazolin-2-amine

(R) 6-chloro-N-{1-[1-(3-methyloxetan-3-yl)piperidin-4-yl]-1H-pyrazol-4-yl}-7-

(spiro[2.2]pentan-1-yl)quinazolin-2-amine

(S) 6-chloro-N-{1-[2-(3-methyloxetan-3-yl)-2-azaspiro[3.3]heptan-6-yl]-1H-pyrazol-4-yl}-

7-(spiro[2.2]pentan-1-yl)quinazolin-2-amine

(R) 6-chloro-N-{1-[2-(3-methyloxetan-3-yl)-2-azaspiro[3.3]heptan-6-yl]-1H-pyrazol-4-yl}-

7-(spiro[2.2]pentan-1-yl)quinazolin-2-amine

(S) 6-chloro-N-{5-chloro-1-[1-(3-methyloxetan-3-yl)piperidin-4-yl]-1H-pyrazol-4-yl}-7-

(spiro[2.3]hexan-1-yl)quinazolin-2-amine

(R) 6-chloro-N-{5-chloro-1-[1-(3-methyloxetan-3-yl)piperidin-4-yl]-1H-pyrazol-4-yl}-7-

(spiro[2.3]hexan-1-yl)quinazolin-2-amine

6-chloro-N-[5-chloro-1-(2-methoxy-2-methylpropyl)-1H-pyrazol-4-yl]-7-[1-(oxetan-3-

yl)piperidin-4-yl]quinazolin-2-amine

(3S,4S) 6-chloro-N-[5-chloro-1-[(3-methyloxetan-3-yl)methyl]-1H-pyrazol-4-yl}-7-[3-

fluoro-1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-amine

(3R,4R) 6-chloro-N-{5-chloro-1-[(3-methyloxetan-3-yl)methyl]-1H-pyrazol-4-yl}-7-[3-

fluoro-1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-amine

(3S,4S) 6-chloro-N-[5-chloro-1-[(3-methyloxetan-3-yl)methyl]-1H-pyrazol-4-yl}-7-[3-

fluoro-1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-amine

(3R,4R) 6-chloro-N-{5-chloro-1-[(3-methyloxetan-3-yl)methyl]-1H-pyrazol-4-yl}-7-[3-

fluoro-1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-amine

6-chloro-N-{5-chloro-1-[2-(difluoromethoxy)-2-methylpropyl]-1H-pyrazol-4-yl}-7-[1-

(oxetan-3-yl)piperidin-4-yl]quinazolin-2-amine

6-chloro-N-[1-(2-methoxy-2-methylpropyl)-5-methyl-1H-pyrazol-4-yl]-7-[1-(oxetan-3-

yl)piperidin-4-yl]quinazolin-2-amine

1-{[4-({6-chloro-7-[1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-yl}amino)-5-methyl-1H-

pyrazol-1-yl]methyl}cyclopropane-1-carbonitrile

6-chloro-N-[1-(2-methoxy-2-methylpropyl)-3-methyl-1H-pyrazol-4-yl]-7-[1-(oxetan-3-

yl)piperidin-4-yl]quinazolin-2-amine

1-{[4-({6-chloro-7-[1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-yl}amino)-3-methyl-1H-

pyrazol-1-yl]methyl}cyclopropane-1-carbonitrile

N-(1-(bicyclo[1.1.1]pentan-1-yl)-1H-pyrazol-4-yl)-6-chloro-7-(1-(3-methyloxetan-3-

yl)piperidin-4-yl)quinazolin-2-amine

2-[4-({6-chloro-7-[1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-yl}amino)-5-methyl-1H-

pyrazol-1-yl]-2-methylpropanenitrile

2-[4-({6-chloro-7-[1-(3-methyloxetan-3-yl)piperidin-4-yl]quinazolin-2-yl}amino)-5-

methyl-1H-pyrazol-1-yl]-2-methylpropanenitrile

N-[1-(bicyclo[1.1.1]pentan-1-yl)-5-methyl-1H-pyrazol-4-yl]-6-chloro-7-[1-(oxetan-3-

yl)piperidin-4-yl]quinazolin-2-amine

N-[1-(bicyclo[1.1.1]pentan-1-yl)-5-methyl-1H-pyrazol-4-yl]-6-chloro-7-[1-(3-

methyloxetan-3-yl)piperidin-4-yl]quinazolin-2-amine

(S) 6-chloro-N-[5-methyl-1-(oxolan-3-yl)-1H-pyrazol-4-yl]-7-[1-(oxetan-3-yl)piperidin-4-

yl]quinazolin-2-amine

(R) 6-chloro-N-[5-methyl-1-(oxolan-3-yl)-1H-pyrazol-4-yl]-7-[1-(oxetan-3-yl)piperidin-4-

yl]quinazolin-2-amine

(S) 6-chloro-7-[1-(3-methyloxetan-3-yl)piperidin-4-yl]-N-[5-methyl-1-(oxolan-3-yl)-1H-

pyrazol-4-yl]quinazolin-2-amine

(R) 6-chloro-7-[1-(3-methyloxetan-3-yl)piperidin-4-yl]-N-[5-methyl-1-(oxolan-3-yl)-1H-

pyrazol-4-yl]quinazolin-2-amine

(3S,4S) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-5-methyl-1H-pyrazol-4-yl]amino}-6-

chloroquinazolin-7-yl)piperidin-1-yl]oxolan-3-ol

(3R,4R) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-5-methyl-1H-pyrazol-4-yl]amino}-6-

chloroquinazolin-7-yl)piperidin-1-yl]oxolan-3-ol

(3S,4S) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-5-methyl-1H-pyrazol-4-yl]amino}-6-

chloroquinazolin-7-yl)piperidin-1-yl]oxolan-3-ol

(3R,4R) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-5-methyl-1H-pyrazol-4-yl]amino}-6-

chloroquinazolin-7-yl)piperidin-1-yl]oxolan-3-ol

(S) 6-chloro-N-[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]-7-[1-(3-

methyloxetan-3-yl)piperidin-4-yl]quinazolin-2-amine

(R) 6-chloro-N-[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]-7-[1-(3-

methyloxetan-3-yl)piperidin-4-yl]quinazolin-2-amine

6-chloro-N-{1-[3-(methoxymethyl)bicyclo[1.1.1]pentan-1-yl]-5-methyl-1H-pyrazol-4-yl}-

7-[1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-amine

6-chloro-N-{1-[3-(methoxymethyl)bicyclo[1.1.1]pentan-1-yl]-5-methyl-1H-pyrazol-4-yl}-

7-[1-(3-methyloxetan-3-yl)piperidin-4-yl]quinazolin-2-amine

(R)(3S,4S) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-6-

methylquinazolin-7-yl)piperidin-1-yl]oxolan-3-ol

(R)(3R,4R) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-6-

methylquinazolin-7-yl)piperidin-1-yl]oxolan-3-ol

(S)(3S,4S) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-6-

methylquinazolin-7-yl)piperidin-1-yl]oxolan-3-ol

(S)(3R,4R) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-6-

methylquinazolin-7-yl)piperidin-1-yl]oxolan-3-ol

4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-6-

methylquinazolin-7-yl)piperidin-1-yl]oxolan-3-ol

(3S,4S) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-1H-pyrazol-4-yl]amino}-6-

chloroquinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol

(3R,4R) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-1H-pyrazol-4-yl]amino}-6-

chloroquinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol

(3S,4S) 4-(4-{2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino]-6-methylquinazolin-7-

yl}piperidin-1-yl)-4-methyloxolan-3-ol

(3R,4R) 4-(4-{2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino]-6-methylquinazolin-7-

yl}piperidin-1-yl)-4-methyloxolan-3-ol

(3S,4S) 4-(4-{2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino]-6-methylquinazolin-7-

yl}piperidin-1-yl)-4-methyloxolan-3-ol

(3R,4R) 4-(4-{2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino]-6-methylquinazolin-7-

yl}piperidin-1-yl)-4-methyloxolan-3-ol

(3S,4S) 4-(4-{2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]-6-methylquinazolin-7-

yl}piperidin-1-yl)-4-methyloxolan-3-ol

(3R,4R) 4-(4-{2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]-6-methylquinazolin-7-

yl}piperidin-1-yl)-4-methyloxolan-3-ol

(3S,4S) 4-(4-{2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]-6-methylquinazolin-7-

yl}piperidin-1-yl)-4-methyloxolan-3-ol

(3R,4R) 4-(4-{2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]-6-methylquinazolin-7-

yl}piperidin-1-yl)-4-methyloxolan-3-ol

(R)(3S,4S) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-6-

methylquinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol

(R)(3R,4R) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-6-

methylquinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol

(S)(3S,4S) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-6-

methylquinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol

(S)(3R,4R) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-6-

methylquinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol

(R)(3S,4S) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-6-

methylquinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol

(R)(3R,4R) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-6-

methylquinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol

(S)(3S,4S) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-6-

methylquinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol

(S)(3R,4R) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-6-

methylquinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol

(R)(3S,4S) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-6-

methylquinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol

(R)(3R,4R) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-6-

methylquinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol

(S)(3S,4S) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-6-

methylquinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol

(S)(3R,4R) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-6-

methylquinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol

(R)(3S,4S) 4-[4-(2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]amino}-6-

methylquinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol

(R)(3R,4R) 4-[4-(2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]amino}-6-

methylquinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol

(S)(3S,4S) 4-[4-(2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]amino}-6-

methylquinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol

(S)(3R,4R) 4-[4-(2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]amino}-6-

methylquinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol

(R)(3S,4S) 4-[4-(2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]amino}-6-

methylquinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol

(R)(3R,4R) 4-[4-(2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]amino}-6-

methylquinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol

(S)(3S,4S) 4-[4-(2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]amino}-6-

methylquinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol

(S)(3R,4R) 4-[4-(2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]amino}-6-

methylquinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol

(3R,4S) 4-[5-chloro-4-({6-chloro-7-[1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-yl}amino)-

1H-pyrazol-1-yl]oxolan-3-ol

(3S,4R) 4-[5-chloro-4-({6-chloro-7-[1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-yl}amino)-

1H-pyrazol-1-yl]oxolan-3-ol

(3R,4R) 4-[5-chloro-4-({6-chloro-7-[1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-yl(amino)-

1H-pyrazol-1-yl]oxolan-3-ol

(3S,4S) 4-[5-chloro-4-({6-chloro-7-[1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-yl}amino)-

1H-pyrazol-1-yl]oxolan-3-ol

(3S,4S) 4-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-

yl}piperidin-1-yl)oxolane-3-carbonitrile

(3R,4R) 4-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-

yl}piperidin-1-yl)oxolane-3-carbonitrile

(3S,4R) 4-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-

yl}piperidin-1-yl)oxolane-3-carbonitrile

(3R,4S) 4-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-

yl}piperidin-1-yl)oxolane-3-carbonitrile

(R)(3S,4S) 4-[4-(6-chloro-2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-

yl]amino}quinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol

(R)(3R,4R) 4-[4-(6-chloro-2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-

yl]amino}quinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol

(S)(3S,4S) 4-[4-(6-chloro-2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-

yl]amino}quinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol

(S)(3R,4R) 4-[4-(6-chloro-2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-