IP Library › Granted Patent US 12,327,192
Granted Patent B2
US 12,327,192 · App. 17/775,807 · Granted Jun 10, 2025

Early detection of pancreatic neoplasms using cascaded machine learning models

Inventors: Alan Yuille (Baltimore, MD); Seyoun Park (Baltimore, MD)
Assignee: The Johns Hopkins University
G06N3/084G06T7/0014G06V10/82G06V20/695G16H50/20G06T2207/20081G06T2207/20084G06T2207/30096
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Quick Facts
Patent No.
US 12,327,192
App. No.
17/775,807
Granted
Jun 10, 2025
Kind
B2
Abstract

Methods, systems, and apparatuses, including computer programs for detecting pancreatic neoplasms. A method includes providing an image as an input to a first model, obtaining first output data generated by the first model based on the first model's processing of the image, the first output data representing a portion of the image that depicts a pancreas, providing the first output data as an input to a second model, obtaining second output data generated by the second model based on the second model's processing of the second input data, the second output indicating whether the depicted pancreas is normal or abnormal, providing the first output data and the second output data as an input to a third model, and obtaining third output data generated by the third model, the third output data including data indicating that the pancreas is normal or data indicating a likely location of a pancreatic neoplasm.

Claims (44)

1. A method for detecting pancreatic neoplasms using cascaded machine learning models, the method comprising:

providing first input data to a first machine learning model, the first input data including data representing an image;

obtaining first output data generated by the first machine learning model based on the first machine learning model's processing of the first input data, the first output data representing a portion of the image that depicts a pancreas;

providing second input data to a second machine learning model, the second input data including the data representing a portion of the image that depicts the pancreas;

obtaining second output data generated by the second machine learning model based on the second machine learning model's processing of the second input data, the second output data representing data that indicates whether the depicted pancreas is (i) normal or (ii) abnormal;

providing third input data to a third machine learning model, the third input data including (i) the data representing a portion of the image that depicts the pancreas and (ii) the data that indicates whether the depicted pancreas is (i) normal or (ii) abnormal;

obtaining third output data generated by the third machine learning model, the third output data including (a) data indicating that the pancreas is normal or (b) data indicating a likely location of one or more pancreatic neoplasms;

determining, based on the third output data, a likely location of one or more pancreatic neoplasms; and

generating data that, when rendered, causes a computer to output display of a visual model of the pancreas that visually highlights, using one or more colors, the likely locations of the one or more pancreatic neoplasms.

2. The method of claim 1 ,

wherein the first machine learning model is a deep neural network that has been trained to segment the image to identify a pancreas in the image.

3. The method of claim 1 , wherein the second machine learning model is a random forest model that has been trained to classify an image of a pancreas as (i) normal or (ii) abnormal.

4. The method of claim 3 , wherein the second machine learning model is a random forest model that has been trained to classify an image of a pancreas as (i) normal, (ii) abnormal with PDAC, (iii) abnormal with PanNet, or (iv) abnormal with Cyst.

5. The method of claim 1 , wherein the data indicating whether the depicted pancreas is abnormal comprises (i) data indicating that the depicted pancreas is abnormal with PDAC or (ii) data indicating that the depicted pancreas is abnormal with PanNet.

6. The method of claim 5 , wherein the second machine learning model is a random forest model that has been trained to classify an image of a pancreas as (i) normal, (ii) abnormal with PDAC, or (iii) abnormal with PanNet.

7. The method of claim 1 , wherein the data indicating whether the depicted pancreas is abnormal comprises (i) data indicating that the depicted pancreas is abnormal with PDAC, (ii) data indicating that the depicted pancreas is abnormal with PanNet, or (iii) abnormal with Cyst.

8. The method of claim 1 , wherein the third machine learning model is a deep neural network that has been trained to generate output data that includes (a) data indicating that the pancreas is normal or (b) data indicating a likely location of one or more pancreatic neoplasms.

9. A system for detecting pancreatic neoplasms using cascaded machine learning models comprising:

one or more computers and one or more storage devices storing instructions that are operable, when executed by the one or more computers, to cause the one or more computers to perform operations comprising:

providing first input data to a first machine learning model, the first input data including data representing an image;

obtaining first output data generated by the first machine learning model based on the first machine learning model's processing of the first input data, the first output data representing a portion of the image that depicts a pancreas;

providing second input data to a second machine learning model, the second input data including the data representing a portion of the image that depicts the pancreas;

obtaining second output data generated by the second machine learning model based on the second machine learning model's processing of the second input data, the second output data representing data that indicates whether the depicted pancreas is (i) normal or (ii) abnormal;

providing third input data to a third machine learning model, the third input data including (i) the data representing a portion of the image that depicts the pancreas and (ii) the data that indicates whether the depicted pancreas is (i) normal or (ii) abnormal;

obtaining third output data generated by the third machine learning model, the third output data including (a) data indicating that the pancreas is normal or (b) data indicating a likely location of one or more pancreatic neoplasms;

determining, based on the third output data, a likely location of one or more pancreatic neoplasms; and

generating data that, when rendered, causes a computer to output display of a visual model of the pancreas that visually highlights, using one or more colors, the likely locations of the one or more pancreatic neoplasms.

10. The system of claim 9 ,

wherein the first machine learning model is a deep neural network that has been trained to segment the image to identify a pancreas in the image.

11. The system of claim 9 , wherein the second machine learning model is a random forest model that has been trained to classify an image of a pancreas as (i) normal or (ii) abnormal.

12. The system of claim 9 , wherein the data indicating whether the depicted pancreas is abnormal comprises (i) data indicating that the depicted pancreas is abnormal with PDAC or (ii) data indicating that the depicted pancreas is abnormal with PanNet.

13. The system of claim 12 , wherein the second machine learning model is a random forest model that has been trained to classify an image of a pancreas as (i) normal, (ii) abnormal with PDAC, or (iii) abnormal with PanNet.

14. The system of claim 9 , wherein the data indicating whether the depicted pancreas is abnormal comprises (i) data indicating that the depicted pancreas is abnormal with PDAC, (ii) data indicating that the depicted pancreas is abnormal with PanNet, or (iii) abnormal with Cyst.

15. The system of claim 14 , wherein the second machine learning model is a random forest model that has been trained to classify an image of a pancreas as (i) normal, (ii) abnormal with PDAC, (iii) abnormal with PanNet, or (iv) abnormal with Cyst.

16. The system of claim 9 , wherein the third machine learning model is a deep neural network that has been trained to generate output data that includes (a) data indicating that the pancreas is normal or (b) data indicating a likely location of one or more pancreatic neoplasms.

17. A non-transitory computer-readable medium storing software comprising instructions executable by one or more computers which, upon such execution, cause the one or more computers to perform operations comprising:

providing first input data to a first machine learning model, the first input data including data representing an image;

obtaining first output data generated by the first machine learning model based on the first machine learning model's processing of the first input data, the first output data representing a portion of the image that depicts a pancreas;

providing second input data to a second machine learning model, the second input data including the data representing a portion of the image that depicts the pancreas;

obtaining second output data generated by the second machine learning model based on the second machine learning model's processing of the second input data, the second output data representing data that indicates whether the depicted pancreas is (i) normal or (ii) abnormal;

providing third input data to a third machine learning model, the third input data including (i) the data representing a portion of the image that depicts the pancreas and (ii) the data that indicates whether the depicted pancreas is (i) normal or (ii) abnormal;

obtaining third output data generated by the third machine learning model, the third output data including (a) data indicating that the pancreas is normal or (b) data indicating a likely location of one or more pancreatic neoplasms;

determining, based on the third output data, a likely location of one or more pancreatic neoplasms; and

generating data that, when rendered, causes a computer to output display of a visual model of the pancreas that visually highlights, using one or more colors, the likely locations of the one or more pancreatic neoplasms.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 18, 2022
From: YUILLE, ALAN; PARK, SEYOUN
To: THE JOHNS HOPKINS UNIVERSITY
Reel/Frame 059949/0754 →
Continuity (2)
Provisional Application 62933946 · Nov 11, 2019
Related Publication 20220392641A1 · Dec 8, 2022
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