IP Library Granted Patent US 12,588,691
Granted Patent B2
US 12,588,691 · App. 17/784,597 · Granted Mar 31, 2026

Diet formulations

Inventors: Leon Marchal (Oegstgeest, NL); Yueming Dersjant Li (Oegstgeest, NL); Abiodun Bello (Wilmington, DE)
Assignee: International N&H Denmark APS
A23K50/75A23K10/18A23K10/30A23K10/37A23K20/111A23K20/142A23K20/147A23K20/189A23K40/10A23K40/30
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Quick Facts
Patent No.
US 12,588,691
App. No.
17/784,597
Granted
Mar 31, 2026
Kind
B2
Abstract

Provided herein are poultry diets containing phytase polypeptides or fragments thereof wherein the diet contains no or substantially no inorganic phosphate.

Claims (16)

1 . A method for improving poultry performance on one or more metrics selected from the group consisting of increased feed efficiency, increased weight gain, reduced feed conversion ratio, improved digestibility of nutrients or energy in a feed, improved nitrogen retention, improved ability to avoid the negative effects of necrotic enteritis, and improved immune response comprising administering an effective amount of a starter, grower, or finisher diet comprising (i) an engineered phytase polypeptide or a fragment thereof comprising phytase activity comprising at least 82% sequence identity with the amino acid sequence set forth in SEQ ID NO:1; and (ii) no inorganic phosphorus to poultry,

wherein improved poultry performance is assessed by comparing to performance in poultry that are administered a starter, grower, or finisher diet that does not comprise (i) the engineered phytase polypeptide or a fragment thereof comprising phytase activity comprising at least 82% sequence identity with the amino acid sequence set forth in SEQ ID NO:1; and (ii) inorganic phosphate.

2 . The method of claim 1 , wherein the poultry is selected from the group consisting of turkeys, ducks, chickens, geese, pheasants, quail, and emus.

3 . The method of claim 2 , wherein chickens are selected from the group consisting of layers and broilers.

4 . The method of claim 1 , wherein said phytase polypeptide comprises an amino acid sequence selected from the group consisting of SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, SEQ ID NO:14, SEQ ID NO:16, SEQ ID NO:17, SEQ ID NO:18, SEQ ID NO:19, SEQ ID NO:20, SEQ ID NO:21, SEQ ID NO:22, SEQ ID NO:23, SEQ ID NO:24, SEQ ID NO:25, SEQ ID NO:26, SEQ ID NO:27, SEQ ID NO:28, SEQ ID NO:29, SEQ ID NO:30, SEQ ID NO:31, SEQ ID NO:32, SEQ ID:NO:33, SEQ ID NO:34, SEQ ID NO:35, SEQ ID NO:36, and SEQ ID NO:37.

5 . The method of claim 1 , further comprising administering one or more of (a) a direct fed microbial comprising at least one bacterial strain, (b) at least one other enzyme other than the engineered phytase polypeptide or fragment thereof, and/or (c) an essential oil.

6 . The method of claim 1 , wherein the starter, grower, or finisher diet further comprises a feed and the engineered phytase polypeptide or fragment thereof is present in an amount of at least about 0.1 g/ton feed.

7 . The method of claim 1 , wherein the starter, grower, or finisher diet further comprises digestible lysine.

8 . The method of claim 1 , wherein the starter, grower, or finisher diet comprises sodium from about 0.13 to 0.17%.

9 . The method of claim 6 , wherein the feed comprises one or more of corn, wheat, soybean meal, grapeseed, rice and/or wheat bran.

10 . The method of claim 1 , wherein the starter, grower, or finisher diet further comprises oat hulls.

11 . The method of claim 1 , wherein the starter, grower, or finisher diet lacks meat and/or bone meal.

12 . The method of claim 5 , wherein the at least one other enzyme is selected from the group consisting of a xylanase, a protease, an amylase, and a glucoamylase.

13 . The method of claim 1 , wherein the diet is a starter diet.

14 . The method of claim 1 , wherein the diet is a grower diet.

15 . The method of claim 1 , wherein the diet is a finisher diet.

Assignments (5)
CHANGE OF NAME Recorded Feb 6, 2024
From: DUPONT NUTRITION BIOSCIENCES APS
To: INTERNATIONAL N&H DENMARK APS
Reel/Frame 066494/0814 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 28, 2022
From: MARCHAL, LEON; LI, YUEMING DERSJANT
To: GENENCOR INTERNATIONAL BV
Reel/Frame 062225/0856 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 28, 2022
From: BELLO, ABIODUN
To: NUTRITION & BIOSCIENCES, USA 4, INC.
Reel/Frame 062225/0906 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 28, 2022
From: GENENCOR INTERNATIONAL BV
To: DUPONT NUTRITION BIOSCIENCES APS
Reel/Frame 062225/0928 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 28, 2022
From: NUTRITION & BIOSCIENCES, USA 4, INC.
To: DUPONT NUTRITION BIOSCIENCES APS
Reel/Frame 062225/0952 →