Pharmaceutical composition for treating cancer, containing mTOR-signaling inhibitor as active ingredient
View Patent ↗The present invention relates to a pharmaceutical composition for preventing or treating cancer, containing a mTOR-signaling inhibitor as an active ingredient. The composition of the present invention exhibits the efficacy of inhibiting the growth of cancer cells and killing cancer cells, and thus can be used as an anticancer agent.
1 . A method for treating cancer comprising:
administering a composition comprising an mTOR signaling inhibitor as an active ingredient,
wherein the mTOR signaling inhibitor is lomitapide, a pharmaceutically acceptable salt thereof, or an optical isomer thereof.
2 . The method of claim 1 , wherein the lomitapide is represented by the following Chemical Formula I:
3 . The method of claim 1 , wherein the cancer is a solid cancer.
4 . The method of claim 3 , wherein the solid cancer is selected from the group consisting of melanoma, brain tumor, benign astrocytoma, malignant astrocytoma, pituitary adenoma, meningioma, central nervous system lymphoma, oligodendroglioma, ependymoma, brain stem tumor, head and neck tumor, laryngeal cancer, oropharyngeal cancer, nasal cavity cancer, nasopharyngeal cancer, salivary gland cancer, hypopharyngeal cancer, thyroid cancer, oral cavity carcinoma, thoracic tumor, small cell lung cancer, non-small cell lung cancer, thymus cancer, mediastinal tumor, esophageal cancer, breast cancer, male breast cancer, celioma, stomach cancer, liver cancer, cholangiocarcinoma, bile duct cancer, pancreatic cancer, small bowel cancer, large bowel cancer, rectal cancer, anal cancer, bladder cancer, kidney cancer, male genital tumor, penis cancer, prostate cancer, female genital cancer, cervical cancer, endometrial cancer, ovarian cancer, uterine sarcoma, vaginal cancer, vulva cancer, female urethral cancer, bone tumor, duodenal cancer, fibrosarcoma, and skin cancer.
5 . The method of claim 1 , wherein the cancer is a blood cancer.
6 . The method of claim 5 , wherein the blood cancer is selected from the group consisting of acute myeloid leukemia, acute lymphocytic leukemia, chronic myeloid leukemia, chronic lymphocytic leukemia, acute monocytic leukemia, multiple myeloma, Hodgkin's lymphoma, and non-Hodgkin's lymphoma.
7 . The method of claim 1 , wherein the composition further comprises an anticancer agent.
8 . The method of claim 7 , wherein the anticancer agent is selected from the group consisting of fluorouracil, irinotecan, an anti-PD1 antibody, bevacizumab, capecitabine, cetuximab, ramucirumab, oxaliplatin, ipilimumab, pembrolizumab, leucovorin, trifluridine/tipiracil, nivolumab, panitumumab, regorafenib, aflibercept, and a combination thereof.
9 . The method of claim 8 , wherein the anticancer agent is selected from the group consisting of fluorouracil, irinotecan, an anti-PD1 antibody, and a combination thereof.