System and method for acquiring optoacoustic data and producing parametric maps thereof
A method is disclosed for generating sinograms by sampling a plurality of transducers acoustically coupled with the surface of a volume of tissue over a period of time after a light pulse at one wavelength, and after another light pulse at a different wavelength, and for processing those sinograms, reconstructing at least two optoacoustic images from the two sinograms, processing the two optoacoustic images to generate two envelope images and generating a parametric map from information in the two envelope images. In an embodiment, motion and tracking are determined to align the envelope images. In an embodiment, at least a second parametric map is produced from information in the same two envelope images. In an embodiment an ultrasound image is also acquired, and the parametric map is coregistered with and overlayed upon the ultrasound image, and then displayed.
1. A method comprising:
generating a first sinogram from a first optoacoustic response signal received from a tissue, the first optoacoustic response signal generated by a pulse of light having a first predominant wavelength;
generating a second sinogram from a second optoacoustic response signal received from the tissue, the second optoacoustic response signal generated by a pulse of light having a second predominant wavelength;
processing the first and second sinograms to create first and second processed sinograms, respectively;
performing image reconstruction based upon the first and second processed sinograms to generate first and second optoacoustic images, respectively;
performing image post-processing on the first and second optoacoustic images to generate first and second envelope images, respectively; and
generating a first parametric map based upon the information contained in the first and second envelope images.
2. The method of claim 1 , wherein generating at least one parametric map comprises:
determining motion and tracking to produce at least two aligned envelope images; and
performing parametric calculations on the at least two aligned envelope images to produce the first parametric map.
3. The method of claim 2 , further comprising:
performing additional parametric calculations on the at least two aligned envelope images to produce a second parametric map.
4. The method of claim 3 , further comprising:
generating a third parametric map based on information in the first and second parametric maps.
5. The method of claim 4 , further comprising:
receiving an ultrasound image from the tissue;
coregistering the ultrasound image with at least one of the first, second, and third parametric maps to produce a coregistered image; and
displaying the coregistered image on a screen of an optoacoustic imaging system.
6. A method comprising:
generating a first multichannel sinogram from a first optoacoustic response signal received from a tissue, the first optoacoustic response signal generated by a pulse of light having a first predominant wavelength;
generating a second multichannel sinogram from a second optoacoustic response signal received from the tissue, the second optoacoustic response signal generated by a pulse of light having a second predominant wavelength;
processing the first and second multi-channel sinograms to create first and second processed sinograms, respectively;
performing image reconstruction based upon the first and second processed sinograms to generate first and second optoacoustic images, respectively;
performing image post-processing on the first and second optoacoustic images to generate first and second post-processed images, respectively, the image post-processing comprising fluence compensation; and
determining motion and tracking to produce at least two aligned post-processed images; and
analyzing the at least two aligned post-processed images from dissimilar wavelength channels to produce a first parametric map.
7. The method of claim 6 , further comprising:
analyzing the at least two aligned post-processed images to produce a second parametric map; and
generating a third parametric map based on information in the first and second parametric maps.
8. The method of claim 7 , further comprising:
receiving an ultrasound image from the tissue;
coregistering the ultrasound image with the third parametric map; and
displaying the coregistered image on a screen of an optoacoustic imaging system.
9. A method comprising the steps of:
generating a first multichannel sinogram from a first optoacoustic response signal received from a tissue, the first optoacoustic response signal generated by a pulse of light having a first predominant wavelength;
generating a second multichannel sinogram from a second optoacoustic response signal received from the tissue, the second optoacoustic response signal generated by a pulse of light having a second predominant wavelength;
processing the first and second multi-channel sinograms to create first and second processed sinograms, respectively;
performing image reconstruction based upon the first and second processed sinograms to generate first and second optoacoustic images, respectively;
performing image post-processing on the first and second optoacoustic images to generate first and second post-processed images, respectively, the image post processing comprising fluence compensation; and
determining motion and tracking to produce first and second aligned post-processed images; and
analyzing the first and second aligned post-processed images from dissimilar wavelength channels to produce a first parametric map.
10. The method of claim 9 , wherein fluence compensation comprises:
determining a common fluence curve that is a function of parameters comprising a depth parameter and an additional parameter;
determining a value for the additional parameter that influences the common fluence curve;
determining a first wavelength specific fluence curve for the first predominant wavelength, wherein the first wavelength specific fluence curve is a function of parameters comprising the depth parameter and a first wavelength specific parameter;
determining a value for the first wavelength specific parameter that influences the first wavelength specific fluence curve;
applying an overall fluence normalization based on both the common fluence curve and the first wavelength specific fluence curve to the first optoacoustic image to compute a first fluence compensated image;
determining a second wavelength specific fluence curve for the second predominant wavelength, wherein the second wavelength specific fluence curve is a function of parameters comprising the depth parameter and a second wavelength specific parameter;
determining a value for the second wavelength specific parameter; and
applying a second overall fluence normalization based on the common fluence curve and the second wavelength specific fluence curve to the second optoacoustic image to compute a second fluence compensated image.
11. The method of claim 10 , wherein fluence compensation further comprises determining a region of interest of the tissue, wherein the region of interest comprises a depth measure used in forming a dependent parameter in at least one of the steps consisting of:
determining the value for the additional parameter;
determining the value for the first wavelength specific parameter; and
determining the value for the second wavelength specific parameter.
12. The method of claim 10 , wherein at least one of the common fluence curve, the first wavelength specific fluence curve or the second wavelength specific fluence curve is computed by computing a statistical feature, the value of the statistical feature varies with depth in an image, wherein the selected fluence curve is based on the value of the statistical feature as a function of depth.