Drug delivery methods and systems
A two-part bioactive agent delivery system, the system including a disposable part comprising an agent reservoir, a bolus chamber, the volume of the bolus chamber being less than the volume of the agent reservoir, an agent outlet, and a valve having a first position communicating the agent reservoir with the bolus chamber and a second position communicating the bolus chamber with the outlet; and a reusable part including a valve driver, a power source and control electronics, the control electronics being adapted to control the valve driver to actuate the valve to deliver bioactive agent from the agent reservoir to the agent outlet; the system further having a spring extending between the agent reservoir piston and a surface of the reusable part or of the disposable part to pressurize the agent reservoir when the spring is compressed and the agent reservoir contains a quantity of bioactive agent.
1. A two-part bioactive agent delivery system, the system comprising:
a disposable part comprising:
a bioactive agent reservoir, the bioactive agent reservoir comprising an agent reservoir piston movable relative to the bioactive agent reservoir,
a bolus chamber, the bolus chamber comprising a bolus piston movable relative to the bolus chamber, the volume of the bolus chamber being less than the volume of the bioactive agent reservoir,
an agent outlet in fluid communication with a transdermal membrane, and
a valve having a first position communicating the bioactive agent reservoir with the bolus chamber and a second position communicating the bolus chamber with the agent outlet; and
a reusable part comprising a valve driver, a power source and control electronics, the control electronics being adapted to control the valve driver to actuate the valve to move to the first position or to the second position to deliver bioactive agent from the bioactive agent reservoir to the agent outlet; and
an agent reservoir loading component extending between the agent reservoir piston and the reusable part, the loading component configured to apply force to the agent reservoir piston to enable the valve to release a dose of bioactive agent from the bioactive agent reservoir to the bolus chamber when the disposable part is connected to the reusable part.