Antiviral drugs targeting the N-terminal domain (NTD) of the coronavirus spike receptor binding domain (RBD)
Antiviral drugs targeting the N-terminal domain (NTD) of the spike receptor binding domain (RBD) and methods of treating a subject suffering from coronavirus.
1. A method for treatment of SARS-COV-1, SARS-CoV-2 (Covid-19) and MERS-CoV, and variants within each, in a mammalian subject in need thereof, comprising administering to the subject an effective amount of the following benzimidazole compounds:
wherein, X can be —CH 2 — or C═O, and R can be —OCH 3 or —NHCH 3 , or a pharmaceutically acceptable salt thereof, optionally in a pharmaceutically acceptable carrier.
2. The method of claim 1 wherein said benzimidazole compound comprises methyl 3-(((3-(5-(1H-benzo[d]imidazol-2-yl)thiophen-3-yl)benzyl)amino)methyl)benzoate.
3. The method of claim 1 wherein said benzimidazole compound comprises 3-(((3-(5-(1H-benzo[d]imidazol-2-yl)thiophen-3-yl)benzyl)amino)methyl)-N-methylbenzamide.
4. The method of claim 1 wherein said benzimidazole compound comprises methyl 3-((3-(5-(1H-benzo[d]imidazol-2-yl)thiophen-3-yl)benzamido)methyl)benzoate.
5. An antiviral drug for treatment of SARS-COV-1, SARS-CoV-2 (Covid-19) and MERS-CoV, and variants within each, in a mammalian subject in need thereof, comprising methyl 3-(((3-(5-(1H-benzo [d]imidazol-2-yl)thiophen-3-yl)benzyl)amino)methyl)benzoate.
6. A method for treatment of SARS-COV-1, SARS-CoV-2 (Covid-19) and MERS-CoV, and variants within each, in a mammalian subject in need thereof, comprising administering to the subject an effective amount of the following piperdine compounds selected from the group consisting of:
1-(3-ethoxy-4-hydroxybenzyl)-N-(3′-fluoro-[1,1′-biphenyl]-3-yl)piperidine-4-carboxamide;
1-(3-ethoxy-4-hydroxybenzyl)-N-(3′-(trifluoromethyl)-[1,1′-biphenyl]-3-yl)piperidine-4-carboxamide;
1-(3-ethoxy-4-hydroxybenzyl)-N-(3′-methoxy-[1,1′-biphenyl]-3-yl)piperidine-4-carboxamide;
N-(3′-chloro-[1,1′-biphenyl]-3-yl)-1-(3-hydroxy-4-methoxybenzyl)piperidine-4-carboxamide;
N-(3′-chloro-[1,1′-biphenyl]-3-yl)-1-(3-ethoxy-4-hydroxybenzyl)piperidine-4-carboxamide; or
N-(4′-chloro-[1,1′-biphenyl]-3-yl)-1-(3-ethoxy-4-hydroxybenzyl)piperidine-4-carboxamide.