High purity 2-naphthylacetonitrile and method for producing same
The present invention provides high purity 2-naphthylacetonitrile with fewer impurities that is useful as a starting material or intermediate for the synthesis of various pharmaceutical products, agricultural chemicals, and chemical products, and a production method thereof. A high purity 2-naphthylacetonitrile having an HPLC purity of 2-naphthylacetonitrile of not less than 95 area %, and containing naphthalene compounds represented by the formulas (a)-(j) at a content of a predetermined area % or below. A method for producing high purity 2-naphthylacetonitrile, including the following step 1 and step 2: step 1: a step of subjecting 2′-acetonaphthone to a Willgerodt reaction in the presence of an additive where necessary, and hydrolyzing the obtained amide compound to give 2-naphthylacetic acid; step 2: a step of reacting the 2-naphthylacetic acid obtained in step 1, a halogenating agent and sulfamide in the presence of a catalyst as necessary in an organic solvent to give 2-naphthylacetonitrile.
1. A high purity 2-naphthylacetonitrile having an HPLC purity of 2-naphthylacetonitrile of not less than 95 area %, comprising one or more kinds selected from the naphthalene compounds represented by the following formulas (a)-(i) as impurities in an amount greater than zero and a content of each naphthalene compound is as follows:
(a)
not more than 0.3 area %
(b)
not more than 0.1 area %
(c)
not more than 1 area %
(d)
not more than 0.1 area %
(e)
not more than 0.05 area %
(f)
not more than 0.05 area %
(g)
not more than 0.1 area %
(h)
not more than 0.05 area %
(i)
not more than 0.05 area %.
2. The high purity 2-naphthylacetonitrile according to claim 1 , comprising one or more kinds selected from the naphthalene compounds represented by the following formulas (a)-(d) as impurities, wherein the content of each naphthalene compound is as follows:
(a)
not more than 0.3 area %
(b)
not more than 0.1 area %
(c)
not more than 1 area %
(d)
not more than 0.1 area %.
3. The high purity 2-naphthylacetonitrile according to claim 1 , comprising the naphthalene compound represented by the following formula (c) as impurity, wherein the content of the naphthalene compound represented by the following formula (c) is not more than 1 area %: