IP Library › Granted Patent US 12,589,025
Granted Patent B2
US 12,589,025 · App. 17/827,573 · Granted Mar 31, 2026

Intraocular devices, systems, and methods

Inventors: Paul Badawi (Atherton, CA); David Y. Badawi (Glenview, IL); Daniel O'Keeffe (San Francisco, CA)
Assignee: SIGHT SCIENCES, INC.
A61F9/0017
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Quick Facts
Patent No.
US 12,589,025
App. No.
17/827,573
Granted
Mar 31, 2026
Kind
B2
Abstract

The present disclosure relates to intraocular implants for treating a condition of the eye, wherein the implant is configured to deliver a drug to the eye. The present disclosure also relates to methods of treating a condition of the eye by delivering a drug from intraocular implants to the posterior chamber (e.g., sulcus), iridocorneal angle, sclera, cornea, limbus, and vitreous.

Claims (78)

1 . A method of placing a drug-eluting implant, comprising a drug, at least partially within a limbus of an eye of a subject, the method comprising:

advancing a distal tip of a cannula of a delivery device through a sclera and the limbus into an anterior chamber of the eye, wherein the drug-eluting implant is disposed within the cannula; and

retracting the cannula and releasing the drug-eluting implant at least partially within the limbus, wherein after releasing the drug-eluting implant from the delivery device, the drug-eluting implant resides partially in the subconjunctival space.

2 . The method of claim 1 , wherein the drug-eluting implant comprises a drug-eluting matrix comprising the drug.

3 . The method of claim 2 , wherein the drug-eluting matrix comprises a polymer.

4 . The method of claim 1 , wherein the drug-eluting implant is erodible.

5 . The method of claim 1 , wherein advancing the distal tip of the cannula comprises entering the sclera posterior to the limbus.

6 . The method of claim 5 , wherein the distal tip of the cannula enters the sclera about 2 mm to about 3 mm posterior to the limbus.

7 . The method of claim 1 , wherein the distal tip of the cannula is advanced about 0.5 mm to about 1.0 mm into the anterior chamber.

8 . The method of claim 1 , wherein the drug-eluting implant is disposed within the cannula about 0.5 mm to about 1.0 mm proximal to the distal tip of the cannula.

9 . The method of claim 1 , wherein the method further comprises positioning the drug-eluting implant at least partially within the limbus prior to retracting the cannula.

10 . The method of claim 9 , wherein positioning the drug-eluting implant comprises visualizing the distal tip of the cannula in the anterior chamber.

11 . The method of claim 10 , wherein the distal tip of the cannula is confirmed, via visualization, to be about 0.5 mm to about 1.0 mm into the anterior chamber.

12 . The method of claim 1 , wherein the cannula is retracted via operation of an actuator of the delivery device.

13 . The method of claim 12 , wherein the drug-eluting implant is released from the delivery device upon retraction of the cannula.

14 . The method of claim 1 , wherein the delivery device comprises a spring configured to retract the cannula.

15 . The method of claim 1 , wherein the drug-eluting implant does not enter the anterior chamber.

16 . The method of claim 1 , wherein the drug diffuses through the limbus or the sclera.

17 . The method of claim 16 , wherein the drug diffuses to the anterior and posterior chamber of the eye.

18 . The method of claim 16 , wherein the drug diffuses through the limbus to the anterior chamber and the cornea.

19 . The method of claim 1 , wherein the drug is a glaucoma drug.

20 . The method of claim 1 , wherein the drug is one or more of travoprost, bimatoprost, latanoprost, or unoprostone.

21 . The method of claim 1 , wherein the drug-eluting implant is cylindrical, a rectangular prism, or a sheet.

22 . The method of claim 1 , wherein the drug-eluting implant is from about 0.5 mm to about 2 mm in length.

23 . The method of claim 1 , wherein the drug-eluting implant comprises poly(lactic-co-glycolic acid) (PLGA), poly(lactic acid) (PLA), or poly(glycolic acid) (PGA).

24 . A method of placing a drug-eluting implant, comprising a drug, at least partially within a limbus of an eye of a subject, the method comprising:

advancing a distal tip of a cannula of a delivery device through a sclera and the limbus into an anterior chamber of the eye, wherein the drug-eluting implant is disposed within the cannula; and

retracting the cannula and releasing the drug-eluting implant at least partially within the limbus, wherein the drug diffuses through the limbus or the sclera.

25 . The method of claim 24 , wherein the drug diffuses to the anterior and posterior chamber of the eye.

26 . The method of claim 24 , wherein the drug diffuses through the limbus to the anterior chamber and the cornea.

27 . The method of claim 24 , wherein the drug-eluting implant comprises a drug-eluting matrix comprising the drug.

28 . The method of claim 27 , wherein the drug-eluting matrix comprises a polymer.

29 . The method of claim 24 , wherein the drug-eluting implant is erodible.

30 . The method of claim 24 , wherein advancing the distal tip of the cannula comprises entering the sclera posterior to the limbus.

31 . The method of claim 30 , wherein the distal tip of the cannula enters the sclera about 2 mm to about 3 mm posterior to the limbus.

32 . The method of claim 24 , wherein the distal tip of the cannula is advanced about 0.5 mm to about 1.0 mm into the anterior chamber.

33 . The method of claim 24 , wherein the drug-eluting implant is disposed within the cannula about 0.5 mm to about 1.0 mm proximal to the distal tip of the cannula.

34 . The method of claim 24 , wherein after releasing the drug-eluting implant from the delivery device, the drug-eluting implant resides fully intramurally.

35 . The method of claim 24 , wherein the drug-eluting implant comprises an elongate implant body comprising a first end and a second end, and after releasing the drug-eluting implant from the delivery device, the first end is positioned in the limbus and the second end is positioned in the sclera.

36 . The method of claim 24 , wherein the drug-eluting implant comprises an elongate implant body comprising a first end and a second end, and after releasing the drug-eluting implant from the delivery device, the first end is positioned in the cornea and the second end is positioned in the limbus.

37 . The method of claim 24 , wherein the drug-eluting implant comprises an elongate implant body comprising a first end and a second end, and after releasing the drug-eluting implant from the delivery device, the elongate implant body traverses the limbus, the first end is positioned in a cornea of the eye, and the second end is positioned in the sclera.

38 . The method of claim 24 wherein the method further comprises positioning the drug-eluting implant at least partially within the limbus prior to retracting the cannula.

39 . The method of claim 38 , wherein positioning the drug-eluting implant comprises visualizing the distal tip of the cannula in the anterior chamber.

40 . The method of claim 39 , wherein the distal tip of the cannula is confirmed, via visualization, to be about 0.5 mm to about 1.0 mm into the anterior chamber.

41 . The method of claim 24 , wherein the cannula is retracted via operation of an actuator of the delivery device.

42 . The method of claim 41 , wherein the drug-eluting implant is released from the delivery device upon retraction of the cannula.

43 . The method of claim 24 , wherein the delivery device comprises a spring configured to retract the cannula.

44 . The method of claim 24 , wherein the drug-eluting implant does not enter the anterior chamber.

45 . The method of claim 24 , wherein the drug is a glaucoma drug.

46 . The method of claim 24 , wherein the drug is one or more of travoprost, bimatoprost, latanoprost, or unoprostone.

47 . The method of claim 24 , wherein the drug-eluting implant is cylindrical, a rectangular prism, or a sheet.

48 . The method of claim 24 , wherein the drug-eluting implant is from about 0.5 mm to about 2 mm in length.

49 . The method of claim 24 , wherein the drug-eluting implant comprises poly(lactic-co-glycolic acid) (PLGA), poly(lactic acid) (PLA), or poly(glycolic acid) (PGA).

50 . The method of claim 49 , wherein the drug-eluting implant resides partially in the subconjunctival space.

51 . A method of placing a drug-eluting implant, comprising a drug, at least partially within a limbus of an eye of a subject, the method comprising:

advancing a distal tip of a cannula of a delivery device through a sclera and the limbus into an anterior chamber of the eye, wherein the drug-eluting implant is disposed within the cannula; and

retracting the cannula and releasing the drug-eluting implant at least partially within the limbus, wherein the cannula is retracted via operation of an actuator of the delivery device.

52 . The method of claim 51 , wherein the drug-eluting implant is released from the delivery device upon retraction of the cannula.

53 . The method of claim 51 , wherein the drug-eluting implant is erodible.

54 . The method of claim 51 , wherein the drug is a glaucoma drug.

55 . The method of claim 51 , wherein the drug is one or more of travoprost, bimatoprost, latanoprost, or unoprostone.

56 . The method of claim 51 , wherein the drug-eluting implant comprises poly(lactic-co-glycolic acid) (PLGA), poly(lactic acid) (PLA), or poly(glycolic acid) (PGA).

57 . A method of placing a drug-eluting implant, comprising a drug, at least partially within a limbus of an eye of a subject, the method comprising:

advancing a distal tip of a cannula of a delivery device through a sclera and the limbus into an anterior chamber of the eye, wherein the drug-eluting implant is disposed within the cannula; and

retracting the cannula and releasing the drug-eluting implant at least partially within the limbus, wherein the delivery device comprises a spring configured to retract the cannula.

58 . The method of claim 57 , wherein the drug-eluting implant is released from the delivery device upon retraction of the cannula.

59 . The method of claim 57 , wherein the drug-eluting implant is erodible.

60 . The method of claim 57 , wherein the drug is a glaucoma drug.

61 . The method of claim 57 , wherein the drug is one or more of travoprost, bimatoprost, latanoprost, or unoprostone.

62 . The method of claim 57 , wherein the drug-eluting implant comprises poly(lactic-co-glycolic acid) (PLGA), poly(lactic acid) (PLA), or poly(glycolic acid) (PGA).

63 . A method of placing a drug-eluting implant, comprising a drug, at least partially within a limbus of an eye of a subject, the method comprising:

advancing a distal tip of a cannula of a delivery device through a sclera and the limbus into an anterior chamber of the eye, wherein the drug-eluting implant is disposed within the cannula; and

retracting the cannula and releasing the drug-eluting implant at least partially within the limbus, wherein the drug-eluting implant does not enter the anterior chamber.

64 . The method of claim 63 , wherein the drug-eluting implant is released from the delivery device upon retraction of the cannula.

65 . The method of claim 63 , wherein the drug-eluting implant is erodible.

66 . The method of claim 63 , wherein the drug is a glaucoma drug.

67 . The method of claim 63 , wherein the drug is one or more of travoprost, bimatoprost, latanoprost, or unoprostone.

68 . The method of claim 63 , wherein the drug-eluting implant comprises poly(lactic-co-glycolic acid) (PLGA), poly(lactic acid) (PLA), or poly(glycolic acid) (PGA).

Assignments (2)
SECURITY INTEREST Recorded Jan 23, 2024
From: SIGHT SCIENCES, INC.
To: HERCULES CAPITAL, INC., AS AGENT
Reel/Frame 066364/0162 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 8, 2022
From: BADAWI, PAUL; BADAWI, DAVID Y.; O'KEEFFE, DANIEL
To: SIGHT SCIENCES, INC.
Reel/Frame 060748/0478 →
Continuity (2)
Provisional Application 63194824 · May 28, 2021
Related Publication 20220378612A1 · Dec 1, 2022
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