IP Library › Granted Patent US 12,350,192
Granted Patent B2
US 12,350,192 · App. 18/898,460 · Granted Jul 8, 2025

Ocular delivery systems and methods

Inventors: David Y. Badawi (Glenview, IL); Daniel O'Keeffe (San Francisco, CA); Paul Badawi (Atherton, CA)
Assignee: SIGHT SCIENCES, INC.
A61F9/0008A61F9/0017A61F9/007A61F9/00736A61F9/00781
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Quick Facts
Patent No.
US 12,350,192
App. No.
18/898,460
Granted
Jul 8, 2025
Kind
B2
Abstract

Described here are systems and methods for accessing Schlemm's canal and for delivering an ocular device or fluid composition therein. The ocular devices may maintain the patency of Schlemm's canal without substantially interfering with transmural fluid flow across the canal. The fluid composition may be a viscoelastic fluid that is delivered into the canal to facilitate drainage of aqueous humor by disrupting the canal and surrounding trabeculocanalicular tissues. Tools for disrupting these tissues and minimally invasive methods for treating medical conditions associated with elevated intraocular pressure, including glaucoma, are also described.

Claims (38)

1. A method for treating glaucoma comprising:

advancing a device at least partially through an anterior chamber of an eye and into Schlemm's canal, wherein the device comprises a conduit for delivering viscoelastic fluid to Schlemm's canal;

advancing the conduit along an arc of Schlemm's canal;

delivering about 50 μl of viscoelastic fluid to Schlemm's canal; and

after delivering the about 50 μl of viscoelastic fluid, disrupting trabecular meshwork to improve flow through a trabeculocanalicular outflow pathway.

2. The method of claim 1 , wherein the trabecular meshwork is disrupted with the conduit.

3. The method of claim 2 , wherein the conduit comprises a polymer and a metal wire.

4. The method of claim 2 , wherein the conduit comprises an indicator configured to assist in identifying a location or a position of the conduit.

5. The method of claim 1 , wherein the device further comprises a handle and a cannula coupled to the handle, wherein the conduit is slidably positioned within the cannula.

6. The method of claim 1 , wherein the handle comprises a slide for advancing the conduit.

7. The method of claim 1 , wherein the cannula is configured to rotate.

8. The method of claim 1 , wherein the viscoelastic fluid is delivered while moving the conduit.

9. The method of claim 1 , wherein delivering the viscoelastic fluid comprises pressurizing a fluid reservoir in fluid communication with the conduit.

10. The method of claim 1 , wherein the conduit comprises one or more of a notch, a hook, and a barb.

11. The method of claim 1 , wherein the trabecular meshwork is disrupted with an ocular device.

12. The method of claim 11 , wherein the conduit comprises a polymer and a metal wire.

13. The method of claim 11 , wherein the conduit comprises an indicator configured to assist in identifying a location or a position of the conduit.

14. A method for treating glaucoma comprising:

advancing a device at least partially through an anterior chamber of an eye and into Schlemm's canal, wherein the device comprises a conduit for delivering viscoelastic fluid to Schlemm's canal;

advancing the conduit along an arc of Schlemm's canal;

delivering about 20 μl of viscoelastic fluid to Schlemm's canal; and

after delivering the about 20 μl of viscoelastic fluid, disrupting trabecular meshwork to improve flow through a trabeculocanalicular outflow pathway.

15. The method of claim 14 , wherein the trabecular meshwork is disrupted with the conduit.

16. The method of claim 15 , wherein the viscoelastic fluid is delivered about at least a 180 degree arc of Schlemm's canal.

17. The method of claim 15 , wherein the device further comprises a handle and a cannula coupled to the handle, wherein the conduit is slidably positioned within the cannula.

18. The method of claim 17 , wherein the handle comprises wheel for advancing the conduit.

19. The method of claim 15 , wherein the viscoelastic fluid is delivered while moving the conduit.

20. The method of claim 15 , wherein delivering the viscoelastic fluid comprises pressurizing a fluid reservoir in fluid communication with the conduit.

21. The method of claim 14 , wherein the trabecular meshwork is disrupted with an ocular device.

22. The method of claim 21 , wherein the device further comprises a handle and a cannula coupled to the handle, wherein the conduit is slidably positioned within the cannula.

23. The method of claim 22 , wherein the cannula is configured to rotate.

24. The method of claim 22 , wherein the device further comprises a fluid reservoir, wherein the viscoelastic fluid is delivered from the fluid reservoir to Schlemm's canal.

25. The method of claim 22 , wherein the handle is capable of being held in a single hand of a user.

26. The method of claim 21 , wherein the visoelastic fluid is delivered about at least a 180 degree arc of Schlemm's canal.

27. The method of claim 21 , wherein delivering the viscoelastic fluid comprises pressurizing a fluid reservoir in fluid communication with the conduit.

28. The method of claim 21 , wherein the viscoelastic fluid is delivered while moving the conduit.

29. The method of claim 21 , wherein the ocular device comprises a suture.

30. The method of claim 14 , wherein conduit is advanced about an about 360 degree arc of Schlemm's canal.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 28, 2024
From: BADAWI, DAVID Y.; O'KEEFFE, DANIEL; BADAWI, PAUL
To: SIGHT SCIENCES, INC.
Reel/Frame 069045/0167 →
SECURITY INTEREST Recorded Oct 28, 2024
From: SIGHT SCIENCES, INC.
To: HERCULES CAPITAL, INC., AS AGENT
Reel/Frame 069283/0908 →
Continuity (11)
Continuation 18130353 · Apr 3, 2023
Continuation 17827494 · May 27, 2022
Continuation 17553671 · Dec 16, 2021
Continuation 17472147 · Sep 10, 2021
Continuation 17239263 · Apr 23, 2021
Continuation 17098231 · Nov 13, 2020
Continuation 16189882 · Nov 13, 2018
Continuation 14816822 · Aug 3, 2015
Continuation 13644748 · Oct 4, 2012
Provisional Application 61613274 · Mar 20, 2012
Related Publication 20250009555A1 · Jan 9, 2025
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