Use of a viscoelastic composition for treating increased intraocular pressure
A viscoelastic medium is useful for the manufacture of a medicament, such as a medical device, for treatment of increased intraocular pressure in the eye of a human or animal. The medicament is administerable into at least one sclerally penetrating fistula of the eye such that the fistula is filled with the medicament. The medium is also useful in a method of treating increased intraocular pressure in the eye of a human or an animal in need thereof, comprising the step of injecting the viscoelastic medium into at least one sclerally penetrating fistula in the eye such that the fistula is filled with the medium.
1. A method of treating increased intraocular pressure in the eye of a human or animal in need thereof, comprising the step of:
(i) injecting a viscoelastic medium directly into at least one sclerally penetrating fistula which extends throughout the sclera to the interior of the eye such that said fistula following said injection is filled with said medium, wherein said fistula achieves drainage of aqueous humor from the eye to lower increased intraocular pressure, and said injecting is performed by releasing the viscoelastic medium from a needle as the needle is withdrawn from the fistula.
2. A method according to claim 1 , wherein said at least one fistula extends between a position distal to the sclerocorneal limbus and the anterior chamber of said eye.
3. A method according to claim 2 , wherein said viscoelastic medium is selected from the group consisting of media comprising stabilised polysaccharides and derivatives thereof.
4. A method according to claim 2 , wherein said injecting of said medium of step (i) immediately follows a step of creating the at least one sclerally penetrating fistula.
5. A method according to claim 1 , wherein said at least one fistula extends between a position distal to the sclerocorneal limbus and the posterior chamber of said eye.
6. A method according to claim 1 , wherein said at least one fistula extends between a position distal to the sclerocorneal limbus and the vitreous body of said eye.
7. A method according to claim 1 , wherein said viscoelastic medium is selected from the group consisting of media comprising stabilised polysaccharides and derivatives thereof.
8. A method according to claim 7 , wherein said viscoelastic medium is selected from media comprising stabilised glycosaminoglycans and derivatives thereof.
9. A method according to claim 8 , wherein said viscoelastic medium is selected from the group consisting of media comprising stabilised hyaluronic acid, stabilised chondroitin sulphate, stabilised heparin, and derivatives thereof.
10. A method according to claim 9 , wherein said viscoelastic medium is selected from the group consisting of media comprising cross-linked hyaluronic acid and derivatives thereof.
11. A method according to claim 1 , wherein said viscoelastic medium is present as gel particles.
12. A method according to claim 1 for treatment of glaucoma in the eye of a human or an animal.
13. A method of treating increased intraocular pressure in the eye of a human or animal in need thereof, comprising the steps of:
(i) creating at least one sclerally penetrating fistula in said eye wherein said fistula extends throughout the sclera to the interior of the eye; and
(ii) injecting a viscoelastic medium directly into said at least one fistula such that said fistula is filled following said injection with said medium, wherein said fistula achieves drainage of aqueous humor from the eye to lower increased intraocular pressure, and said injecting is performed by releasing the viscoelastic medium from a needle as the needle is withdrawn from the fistula.
14. A method according to claim 13 , wherein said creating of at least one fistula of step (i) is immediately followed by said injecting of said medium of step (ii).
15. A method according to claim 13 , wherein said at least one fistula extends between a position distal to the sclerocorneal limbus and the anterior chamber of said eye.
16. A method according to claim 13 , wherein said at least one fistula extends between a position distal to the sclerocorneal limbus and the posterior chamber of said eye.
17. A method according to claim 13 , wherein said at least one fistula extends between a position distal to the sclerocorneal limbus and the vitreous body of said eye.
18. A method according to claim 13 , wherein said viscoelastic medium is selected from the group consisting of media comprising stabilised polysaccharides and derivatives thereof.
19. A method according to claim 18 , wherein said viscoelastic medium is selected from media comprising stabilised glycosaminoglycans and derivatives thereof.
20. A method according to claim 19 , wherein said viscoelastic medium is selected from the group consisting of media comprising stabilised hyaluronic acid, stabilised chondroitin sulphate, stabilised heparin, and derivatives thereof.
21. A method according to claim 20 , wherein said viscoelastic medium is selected from the group consisting of media comprising cross-linked hyaluronic acid and derivatives thereof.
22. A method according to claim 13 , wherein said viscoelastic medium is present as gel particles.
23. A method according to claim 13 for treatment of glaucoma in the eye of a human or an animal.