IP Library Granted Patent US 7,207,965
Granted Patent B2
US 7,207,965 · App. 10/869,166 · Granted Apr 24, 2007

Shunt for the treatment of glaucoma

Assignee: SOLX, Inc.
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Quick Facts
Patent No.
US 7,207,965
App. No.
10/869,166
Granted
Apr 24, 2007
Kind
B2
Abstract

A system is provided for reducing intraocular hypertension, the system having an implantable shunt, with a planar member having at least one microchannel disposed within the planar member. There is an inflow port disposed proximate to a first end of the microchannel and an outflow port disposed proximate to a second end of the microchannel. The inflow port is configured such that when the implantable shunt is implanted, the inflow port is located approximately within the region of an angle of an anterior chamber.

Claims (47)

1. A system for reducing intraocular hypertension, the system comprising:

an implantable shunt, said implantable shunt comprising;

a planar member;

at least one microchannel disposed within said planar member;

an inflow port disposed proximate to a first end of said microchannel;

an outflow port disposed proximate to a second end of said microchannel;

said inflow port configured such that when said implantable shunt is implanted, said inflow port is located about approximately within the region of an angle of an anterior chamber and said outflow port is disposed in a suprachoroidal plane; and

at least one reservoir communicating with said second end of said microchannel.

2. The system according to claim 1 , wherein said planar member has a thickness less than 50 microns.

3. The system according to claim 2 , wherein said thickness of said planar member is between 5 and 25 microns.

4. The system according to claim 1 , further comprising at least one anchor.

5. The system according to claim 4 , wherein said anchor is selected from the group consisting of barbs, hooks, and sutures.

6. The system according to claim 1 , further comprising at least one reservoir communicating with said first end of said microchannel.

7. The system according to claim 1 , wherein said at least one microchannel comprises fewer than 200 microchannels.

8. The system according to claim 1 wherein flow of aqueous fluid from said anterior chamber is modulatable.

9. The system according to claim 8 wherein said at least one microchannel comprises a plurality of microchannels, about approximately 40% of microchannels in said plurality of microchannels being configured to be opened.

10. The system according to claim 1 , further comprising at least one sacrificial microchannel closure.

11. The system according to claim 10 , wherein said closure is photo-ablatable.

12. The system according to claim 10 , wherein said closure is doped with chromophores.

13. The system according to claim 1 , wherein said at least one microchannel comprises between 10 and 100 microchannels.

14. The system according to claim 1 , wherein said system is comprised of at least one biocompatible material selected from the group of materials consisting of gold, platinum, stainless steel, titanium, nickel, molybdenum, biocompatible metals, biocompatible metal alloys, biocompatible ceramics, biocompatible polymers and combinations thereof.

15. A method for the reduction of intraocular pressure in an eye of a subject, said method comprising:

providing an implantable generally planar microchannel shunt;

implanting said shunt in said eye, such that a first end of said shunt is disposed proximate to an angle of an anterior chamber of said eye and a second end is disposed in a suprachoroidal plane; and

permitting aqueous flows to migrate from said anterior chamber through at least one microchannel disposed within said shunt; and

photo-ablating a sacrificial microchannel closure, thereby increasing flow of said aqueous flow through said shunt.

16. The method according to claim 15 , further comprising disposing photo-ablating tissue between said first end and said anterior channel.

17. The method according to claim 15 , further comprising: retracting tissue anterior to the first end of said shunt; and photo-ablating an intervening tissue layer with a laser.

18. The method according to claim 15 , wherein said photo-ablating comprises using a goniolens.

19. The method according to claim 15 further comprising a modulation of aqueous fluid flow.

20. The method according to claim 15 further comprising introducing a hydrophilic polymer during said implanting.

21. An implantable shunt for glaucoma, said shunt comprising:

a generally planar structure having a first end and a second end;

at least one microchannel disposed within said planar structure, said microchannel substantially extending from said first end to said second end, wherein said first end is implanted proximate an angle of an anterior chamber of an eye and said second end is implanted in a suprachoroidal plane; and at least one outflow reservoir coupled to said second end.

22. The shunt according to claim 21 , wherein said planar structure is a material selected from the group of materials consisting of: gold, platinum, stainless steel, nickel, molybdenum, titanium, biocompatible metals, biocompatible metal alloys, biocompatible polymers and combinations thereof.

23. The shunt according to claim 21 , further comprising at least one front channel in said structure.

24. The shunt according to claim 21 , further comprising at least one side channel in said structure.

25. The shunt according to claim 21 , wherein said structure is comprised of two generally planar bodies coupled together with said microchannels disposed therebetween.

26. The shunt according to claim 21 , wherein said generally planar structure has a shape selected from the group consisting of concave, convex, and substantially planar.

27. The shunt according to claim 21 , wherein said structure has a variable thickness.

28. The shunt according to claim 21 , wherein at least one of said microchannels are closed microchannels.

29. The shunt according to claim 28 , wherein said closed microchannels are selectively openable.

30. The shunt according to claim 21 , further comprising at least one inflow reservoir coupled to said first end.

31. The shunt according to claim 21 , wherein said inflow reservoir and said outflow reservoir have ventilation holes.

32. The shunt according to claim 21 , further comprising a coating.

33. The shunt according to claim 32 , wherein said coating is a coating selected from the group of coatings consisting of mineral coatings, pharmaceutical coatings, radiological coatings, polymer coatings, metallic coatings, and combinations thereof.

34. The shunt according to claim 21 further comprising a manipulation aid.

Assignments (7)
RELEASE OF SECURITY INTEREST Recorded Oct 15, 2010
From: TEARLAB CORPORATION (FORMERLY KNOWN AS OCCULOGIX, INC.)
To: SOLX, INC.
Reel/Frame 025137/0719 →
RELEASE OF SECURITY INTEREST Recorded Oct 15, 2010
From: PETER M. ADAMS, DOUG P. ADAMS, AND JOHN SULLIVAN, COLLECTIVELY AS THE STOCKHOLDER REPRESENTATIVE COMMITTEE, ON BEHALF OF THE PARTICIPATING RIGHTS HOLDERS OF SOLX, INC.
To: SOLX, INC.
Reel/Frame 025137/0725 →
CORRECTING TYPOGRAPHICAL ERROR OF A PATENT NUMBER PREVIOUSLY RECORDED ON REEL/FRAME 020571/0577 Recorded Mar 5, 2008
From: SOLX,INC.
To: OCCULOGIX, INC.
Reel/Frame 020599/0776 →
SECURITY AGREEMENT Recorded Feb 28, 2008
From: SOLX, INC.
To: OCCULOGIX, INC.
Reel/Frame 020571/0577 →
SECURITY AGREEMENT Recorded Jan 25, 2008
From: SOLX, INC.
To: DOUG P. ADAMS, JOHN SULLIVAN AND PETER M. ADAMS, COLLECTIVELY AS THE STOCKHOLDER REPRESENTATIVE COMMITTEE ON BEHALF OF THE PARTICIPATING RIGHTS HOLDERS OF SOLX, INC.
Reel/Frame 020403/0845 →
SECURITY AGREEMENT Recorded Jan 31, 2007
From: SOLX, INC.
To: PETER M. ADAMS, DOUG P. ADAMS, AND JOHN SULLIVAN, COLLECTIVELY AS THE STOCKHOLDER REPRESENTATIVE COMMITTEE, ON BEHALF OF THE PARTICIPATING RIGHTS HOLDERS OF SOLX, INC.
Reel/Frame 018826/0382 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 2, 2004
From: SIMON, GABRIEL
To: SOLX INC.
Reel/Frame 014814/0013 →
Continuity (2)
Provisional Application 6047889500 · Jun 16, 2003
Related Publication 20040254521A1 · Dec 16, 2004