Systems and methods for endothelial regeneration of schlemm's canal
The present disclosure provides systems, methods, and compositions for delivering endothelial cells into Schlemm's canal to restore physiological outflow in glaucoma and other ocular disorders. The document encompasses diverse devices and hydrogel carriers suitable for delivering endothelial cells, including conduits, microcatheters, scaffolds, stents, support devices, Schlemm's canal expanders, viscodilation balloons, tensioning sutures, hydrogel sleeves, and injectable formulations. The endothelial cells may be combined with extracellular matrix components, drugs, or growth factors, and may be delivered using controlled-release hydrogels to ensure uniform circumferential seeding. The system enables removal of dysfunctional Schlemm's canal endothelial cells, OCT/OCTA-guided functional analysis, and re-endothelialization via bioengineered scaffolds. Embodiments further integrate artificial intelligence for intraoperative guidance, predictive analytics, and postoperative monitoring of endothelial integration. Safe dosing strategies are disclosed to avoid canal obstruction, and commercial applications include combination biologic-device products and digital health solutions.
1 . A device comprising:
a catheter, configured for insertion into an incision providing access to Schlemm's canal of an eye; and
a tubular hydrogel sleeve positioned around a distal shaft of the catheter, the tubular hydrogel sleeve comprising Schlemm's canal endothelial cells.
2 . The device of claim 1 , wherein the incision is in a cornea.
3 . The device of claim 1 , wherein the tubular hydrogel sleeve comprises polyethylene glycol (PEG).
4 . The device of claim 1 , wherein the tubular hydrogel sleeve comprises collagen.
5 . The device of claim 1 , wherein the tubular hydrogel sleeve comprises glucose.
6 . The device of claim 1 , wherein the tubular hydrogel sleeve comprises nitinol.
7 . The device of claim 1 , wherein the tubular hydrogel sleeve comprises nanopores.
8 . The device of claim 1 , further comprising a lumen configured to deliver a viscoelastic through the catheter.
9 . A device comprising:
a catheter, configured for insertion into an incision providing access to Schlemm's canal of an eye; and
a hydrogel coating bonded to a surface of a distal shaft of the catheter, the hydrogel coating comprising Schlemm's canal endothelial cells.
10 . The device of claim 9 , wherein the incision is in a sclera.
11 . The device of claim 9 , wherein the hydrogel coating comprises hyaluronic acid.
12 . The device of claim 9 , wherein the hydrogel coating comprises alginate.
13 . The device of claim 9 , further comprising a lumen configured to deliver a viscoelastic through the catheter.
14 . The device of claim 1 , wherein the tubular hydrogel sleeve includes hyaluronic acid.
15 . The device of claim 9 , wherein the hydrogel coating comprises polyethylene glycol (PEG).