Efficient synthesis of diglycolamide molecules
A method for producing a diglycolamide molecule having the formula: wherein R 1 and R 2 are independently selected from alkyl groups (R) and acyl groups (C(O)R) in which the alkyl groups (R) contain 1-30 carbon atoms and optionally contain an ether or thioether linkage between carbon atoms, and R 5 and R 6 are independently selected from hydrogen atom and alkyl groups containing 1-3 carbon atoms; and one or both pairs of R 1 and R 2 are optionally interconnected to form a ring; the method comprising: combining a diglycolic acid molecule (A) and a secondary amine (B) to form a salt intermediate (C), and heating the salt intermediate (C) to a temperature of 100° C. to 300° C. to form the diglycolamide of Formula (1) in a dehydration process, wherein the method is shown schematically as follows:
1. A method for producing a diglycolamide molecule having the formula:
wherein R 1 and R 2 are independently selected from alkyl groups (R) and acyl groups (C(O)R) in which the alkyl groups (R) contain 1-30 carbon atoms and optionally contain an ether or thioether linkage between carbon atoms, and R 5 and R 6 are independently selected from hydrogen atom and alkyl groups containing 1-3 carbon atoms; and one or both pairs of R 1 and R 2 are optionally interconnected to form a ring;
the method comprising: combining a diglycolic acid molecule (A) and a secondary amine (B) to form a salt intermediate (C), and heating the salt intermediate (C) to a temperature of 100° C. to 300° C. to form the diglycolamide of Formula (1) in a dehydration process, wherein the method is shown schematically as follows:
2. The method of claim 1 , wherein R 5 and R 6 are hydrogen atoms.
3. The method of claim 1 , wherein R 5 and R 6 are methyl groups.
4. The method of claim 1 , wherein R 1 and R 2 are the same.
5. The method of claim 1 , wherein R 1 and R 2 are different.
6. The method of claim 5 , wherein R 1 contains 1-3 carbon atoms and R 2 contains 4-30 carbon atoms.
7. The method of claim 1 , wherein (A) and (B) are combined with a solvent having a boiling point of at least 100° C.
8. The method of claim 1 , wherein (A) and (B) are ball milled in the absence of a solvent.