Substituted nucleosides, nucleotides and analogs thereof
Disclosed herein are nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a HCV infection with one or more nucleotide analogs.
1. A compound of Formula (I), or a pharmaceutically acceptable salt thereof, having the structure:
wherein:
B 1 is an optionally substituted
R 1 is an optionally substituted C 1-6 alkyl;
R 2 is halo or —OR 7A ;
R 3 is O;
Z p is O;
R p1 is an —O-optionally substituted C 1-6 alkyl;
R 6C is an unsubstituted C 1-6 alkyl, and
R 7A is hydrogen.
2. The compound of claim 1 , wherein R 2 is halo.
3. The compound of claim 2 , wherein R 2 is fluoro.
4. The compound of claim 1 , wherein R 2 is-OR 7A .
5. The compound of claim 4 , wherein R 7A is hydrogen.
6. The compound of claim 1 , wherein R 1 is an optionally substituted ethyl.
7. The compound of claim 6 , having a structure selected from the group consisting of:
or a pharmaceutically acceptable salt of the foregoing.
8. The compound of claim 7 , having a structure selected from the group consisting of:
or a pharmaceutically acceptable salt of the foregoing.