IP Library Granted Patent US 12,251,555
Granted Patent B2
US 12,251,555 · App. 17/850,554 · Granted Mar 18, 2025

Methods and systems for treating hypertension using an implantable stimulator

Inventors: Jeffrey H. Greiner (Valencia, CA); David K. L. Peterson (Valencia, CA); Chuladatta Thenuwara (Castaic, CA)
Assignee: Valencia Bioscience, Inc.
A61N1/0504A61H39/002A61N1/36117A61N1/36175A61N1/37205A61N1/3756A61H2201/5005A61H2201/5035A61H2201/5038A61H2201/5097A61N1/3605A61N1/36125A61N1/3758A61N1/3782Y10S128/907
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 12,251,555
App. No.
17/850,554
Granted
Mar 18, 2025
Kind
B2
Abstract

A method of treating hypertension includes an implantable stimulator generating stimulation sessions at a duty cycle that is less than 0.05 and applying the stimulation sessions by way of the central electrode and the annular electrode to a location associated with the hypertension and within a patient.

Claims (35)

1. A method of treating hypertension, comprising:

generating, by an implantable stimulator, stimulation sessions at a duty cycle that is less than 0.05, wherein

the duty cycle is a ratio of T3 to T4, where T3 is a first number and where T4 is a second number,

each stimulation session included in the stimulation sessions has a duration of T3 minutes and occurs at a rate of once every T4 minutes, and

the implantable stimulator comprises a central electrode of a first polarity centrally located on a first surface of a housing of the implantable stimulator and an annular electrode of a second polarity and that is spaced apart from the central electrode; and

applying, by the implantable stimulator, the stimulation sessions by way of the central electrode and the annular electrode to a location associated with the hypertension and within the patient.

2. The method of claim 1 , wherein the implantable stimulator is powered by a rechargeable battery.

3. The method of claim 2 , further comprising receiving, by the implantable stimulator from an external controller, a power signal configured to recharge the rechargeable battery.

4. The method of claim 1 , wherein the implantable stimulator is powered by a primary battery.

5. The method of claim 4 , wherein the primary battery has an internal impedance greater than 5 ohms.

6. The method of claim 1 , wherein the housing of the implantable stimulator is coin-sized and coin-shaped.

7. The method of claim 1 , wherein the annular electrode is located on the first surface of the housing.

8. The method of claim 1 , wherein the annular electrode comprises a ring electrode located around a perimeter edge of the housing.

9. The method of claim 8 , wherein the annular electrode comprises a plurality of electrode segments each having the second polarity and spaced apart from each other in a circumferential pattern around the central electrode.

10. The method of claim 1 , wherein T3 is at least 10 minutes and less than 60 minutes, and wherein T4 is at least 1440 minutes.

11. The method of claim 1 , wherein:

a lead is attached to the implantable stimulator; and

the applying the stimulation sessions further comprises applying one or more of the stimulation sessions by way of a plurality of electrodes located on the lead.

12. An implantable stimulator, comprising:

a housing;

a central electrode of a first polarity and centrally located on a first surface of the housing;

an annular electrode of a second polarity and that surrounds the central electrode on the first surface of the housing, the annular electrode being spaced apart from the central electrode; and

pulse generation circuitry located within the housing, the pulse generation circuitry configured to

generate stimulation sessions at a duty cycle that is less than 0.05, and

apply the stimulation sessions to a location associated with the hypertension and within a patient by way of the central electrode and the annular electrode;

wherein

the duty cycle is a ratio of T3 to T4, where T3 is a first number and where T4 is a second number, and

each stimulation session included in the stimulation sessions has a duration of T3 minutes and occurs at a rate of once every T4 minutes.

13. The implantable stimulator of claim 12 , further comprising a rechargeable battery within the housing and configured to provide power to the pulse generation circuitry.

14. The implantable stimulator of claim 13 , further comprising a receiver circuit within the housing and configured to receive, from an external controller, a power signal configured to recharge the rechargeable battery.

15. The implantable stimulator of claim 12 , further comprising a primary battery within the housing and configured to provide power to the pulse generation circuitry.

16. The implantable stimulator of claim 15 , wherein the primary battery has an internal impedance greater than 5 ohms.

17. The implantable stimulator of claim 12 , wherein the housing of the implantable stimulator is coin-sized and coin-shaped.

18. The implantable stimulator of claim 12 , wherein the annular electrode is located on the first surface of the housing.

19. The implantable stimulator of claim 12 , wherein the annular electrode comprises a ring electrode located around a perimeter edge of the housing.

Assignments (4)
RELEASE OF SECURITY INTEREST Recorded May 6, 2026
From: MEDTRONIC, INC.
To: VALENCIA BIOSCIENCE, INC.
Reel/Frame 075721/0223 →
SECURITY INTEREST Recorded Oct 27, 2023
From: VALENCIA BIOSCIENCE, INC.
To: MEDTRONIC, INC.
Reel/Frame 065382/0738 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 1, 2022
From: VALENCIA TECHNOLOGIES CORPORATION
To: VALENCIA BIOSCIENCE, INC.
Reel/Frame 060425/0589 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 27, 2022
From: GREINER, JEFFREY H.; PETERSON, DAVID K.L.; THENUWARA, CHULADATTA
To: VALENCIA TECHNOLOGIES CORPORATION
Reel/Frame 060324/0483 →
Continuity (13)
Continuation 16693008 · Nov 22, 2019
Continuation 15700013 · Sep 8, 2017
Division 14805355 · Jul 21, 2015
Continuation 14446500 · Jul 30, 2014
Division 13598575 · Aug 29, 2012
Provisional Application 61676275 · Jul 26, 2012
Provisional Application 61674691 · Jul 23, 2012
Provisional Application 61672661 · Jul 17, 2012
Provisional Application 61672257 · Jul 16, 2012
Provisional Application 61609875 · Mar 12, 2012
Provisional Application 61606995 · Mar 6, 2012
Provisional Application 61575869 · Aug 30, 2011
Related Publication 20220323746A1 · Oct 13, 2022
References Cited (91)
US 4031899A · Renirie · 1977 [cited by applicant]
US 4157720A · Greatbatch et al. · 1979 [cited by applicant]
US 4231027A · Mann et al. · 1980 [cited by applicant]
US 4345604A · Renirie · 1982 [cited by applicant]
US 4528072A · Kurosawa et al. · 1985 [cited by applicant]
US 4535784A · Rohlicek et al. · 1985 [cited by applicant]
US 4566064A · Whitaker · 1986 [cited by applicant]
US 5195517A · Chen · 1993 [cited by applicant]
US 5199428A · Obel et al. · 1993 [cited by applicant]
US 5211175A · Gleason et al. · 1993 [cited by applicant]
US 5250068A · Ideguchi et al. · 1993 [cited by applicant]
US 5251637A · Shalvi · 1993 [cited by applicant]
US 5372605A · Adams et al. · 1994 [cited by applicant]
US 5544656A · Pitsillides et al. · 1996 [cited by applicant]
US 5609617A · Shealy et al. · 1997 [cited by applicant]
US 5707400A · Terry, Jr. et al. · 1998 [cited by applicant]
US 5891181A · Zhu · 1999 [cited by applicant]
US 6006134A · Hill et al. · 1999 [cited by applicant]
US 6178352B1 · Gruzdowich et al. · 2001 [cited by applicant]
US 6393324B2 · Gruzdowich et al. · 2002 [cited by applicant]
US 6522926B1 · Kieval et al. · 2003 [cited by applicant]
US 6658298B2 · Gruzdowich et al. · 2003 [cited by applicant]
US 6735475B1 · Whitehurst et al. · 2004 [cited by applicant]
US 6839596B2 · Nelson et al. · 2005 [cited by applicant]
US 6950707B2 · Whitehurst · 2005 [cited by applicant]
US 6978174B2 · Gelfand et al. · 2005 [cited by applicant]
US 7003352B1 · Whitehurst · 2006 [cited by applicant]
US 7013177B1 · Whitehurst et al. · 2006 [cited by applicant]
US 7046499B1 · Imani et al. · 2006 [cited by applicant]
US 7136701B2 · Greatbatch et al. · 2006 [cited by applicant]
US 7155279B2 · Whitehurst et al. · 2006 [cited by applicant]
US 7162303B2 · Levin et al. · 2007 [cited by applicant]
US 7171266B2 · Gruzdowich et al. · 2007 [cited by applicant]
US 7203548B2 · Whitehurst et al. · 2007 [cited by applicant]
US 7292890B2 · Whitehurst et al. · 2007 [cited by applicant]
US 7321792B1 · Min et al. · 2008 [cited by applicant]
US 7373204B2 · Gelfand et al. · 2008 [cited by applicant]
US 7440806B1 · Whitehurst et al. · 2008 [cited by applicant]
US 7444180B2 · Kuzma et al. · 2008 [cited by applicant]
US 7610100B2 · Jaax et al. · 2009 [cited by applicant]
US 7620451B2 · Demarais et al. · 2009 [cited by applicant]
US 7657316B2 · Jaax et al. · 2010 [cited by applicant]
US 7962219B2 · Jaax et al. · 2011 [cited by applicant]
US 20020016568A1 · Lebel et al. · 2002 [cited by applicant]
US 20030078642A1 · Malaney et al. · 2003 [cited by applicant]
US 20030158588A1 · Rizzo et al. · 2003 [cited by applicant]
US 20030171790A1 · Nelson et al. · 2003 [cited by applicant]
US 20030187485A1 · Sturman et al. · 2003 [cited by applicant]
US 20030195583A1 · Gruzdowich et al. · 2003 [cited by applicant]
US 20030220668A1 · Shealy · 2003 [cited by applicant]
US 20030236558A1 · Whitehurst et al. · 2003 [cited by applicant]
US 20050107832A1 · Bernabei · 2005 [cited by applicant]
US 20050228460A1 · Levin et al. · 2005 [cited by applicant]
US 20050234533A1 · Schulman et al. · 2005 [cited by applicant]
US 20060041283A1 · Gelfand · 2006 [cited by examiner]
US 20060184209A1 · John et al. · 2006 [cited by applicant]
US 20070005119A1 · Crohn · 2007 [cited by applicant]
US 20070219595A1 · He · 2007 [cited by applicant]
US 20070255319A1 · Greenberg et al. · 2007 [cited by applicant]
US 20070265680A1 · Liu · 2007 [cited by applicant]
US 20080015572A1 · Johnson et al. · 2008 [cited by applicant]
US 20080091255A1 · Caparso et al. · 2008 [cited by applicant]
US 20080097529A1 · Parramon et al. · 2008 [cited by applicant]
US 20090192555A1 · Schleicher et al. · 2009 [cited by applicant]
US 20090210026A1 · Solberg et al. · 2009 [cited by applicant]
US 20090292341A1 · Parramon et al. · 2009 [cited by applicant]
US 20100042137A1 · Oronsky et al. · 2010 [cited by applicant]
US 20100069992A1 · Aghassian et al. · 2010 [cited by applicant]
US 20100211132A1 · Nimmagadda et al. · 2010 [cited by applicant]
US 20100228310A1 · Shuros · 2010 [cited by examiner]
US 20100324624A1 · Chang · 2010 [cited by applicant]
US 20100327887A1 · Denison et al. · 2010 [cited by applicant]
US 20110106219A1 · Cauller et al. · 2011 [cited by applicant]
US 20110106220A1 · Degiorgio et al. · 2011 [cited by applicant]
US 20110112603A1 · Degiorgio et al. · 2011 [cited by applicant]
US 20110172739A1 · Mann et al. · 2011 [cited by applicant]
US 20110218589A1 · Degiorgio et al. · 2011 [cited by applicant]
US 20110218590A1 · Degiorgio et al. · 2011 [cited by applicant]
US 20120022612A1 · Littlewood et al. · 2012 [cited by applicant]
US 20120259390A1 · Canion · 2012 [cited by applicant]
US 20130041396A1 · Ryotokuji · 2013 [cited by applicant]
EP 1145736 · 2001 [cited by applicant]
WO 0141869 · 2001 [cited by applicant]
WO 0200294 · 2002 [cited by applicant]
Acupuncture Today: Electroacupuncture, Feb. 1, 2004. Retrieved on-line Aug. 9, 2006 at http://www.acupuncturetoday.com/abc/electroacupuncture.php. [cited by applicant]
Who Standard Acupuncture Point Locations in the Western Pacific Region, published by the World Health Organization (WHO), Western Pacific Region, 2008, ISBN 978 92 9061 248 7. The Table of Contents, Forward (p. v-vi), G… [cited by applicant]
Cheung, et al., The Mechanism of Acupuncture Therapy and Clinical Case Studies, Taylor and Francis, published in London. 2001. ISBN 0-415-27254-8. The Forward, Chapters 1-3, and 5. [cited by applicant]
Li, et al., Neural Mechanism of Electroacupuncture's Hypotensive Effects, Autonomic Neuroscience: Basic and Clinical 157 (2010) 24-30. [cited by applicant]
Song, Kiseok et al.,The Compact Electro-Acupuncture System for Multi-Modal Feedback Electro-Acupuncture Treatment, 34th Annual International Conference of the IEEE EMBS, San Diego, CA, USA, 28 Aug.-Sep. 1, 2012. [cited by applicant]
Wikipedia, et al., Acupuncture, http://en.wikipedia.org/wiki/Acupuncture, as accessed Mar. 15, 2013. [cited by applicant]
Wikipedia, et al., Electroacupuncture, http://en.wikipedia.org/wiki/Electroacupuncture, as accessed Mar. 15, 2013. [cited by applicant]