Small molecule inhibitors targeting
Disclosed herein are compounds that can prevent and treat C. difficile by inhibiting sporulation. Also disclosed herein are compositions and formulations comprising the compound disclosed herein. Methods of preventing and treating C. difficile comprising administering the compounds described herein are also disclosed.
1. A compound represented by the formula:
2. The compound of claim 1 , wherein the compound is represented by the formula:
3. The compound of claim 1 , wherein the compound is represented by:
4. The compound of claim 1 , wherein the compound is represented by:
5. A pharmaceutical composition, comprising the compound of claim 1 and an antibiotic.
6. A formulation, comprising the compound of claim 1 and a pharmaceutically acceptable excipient.
7. A method of preventing and treating C. difficile , comprising administering to a patient in need thereof a therapeutically effective amount of the compound of claim 1 .