Compositions and methods for treating hypertension
Disclosed herein are compositions and methods for delivering cannabidiol to subject in need of hypertension treatment. The disclosed compositions are orally delivered. Further disclosed are kits comprising the disclosed compositions as part of a method of delivering the cannabidiol-containing compositions.
1. A composition for treating hypertension in a human, consisting of:
a) from about 0.5% to about 20% by weight of CBD oil wherein the CBD oil contains from about 80% to about 92% by weight of cannabidiol;
b) from about 0.5% to about 60% by weight of sunflower oil;
c) from about 5% to about 20% by weight of a bile salt wherein the bile salt is selected from the group consisting of deoxycholic acid, taurocholate acid, glycocholic acid, or mixtures thereof; and
(d) the balance being from about 20% to about 99% by weight of one or more carriers is selected from the group consisting of colloidal silicon dioxide, tapioca starch, or mixtures thereof.
2. The composition according to claim 1 , consisting of from about 2% to about 5% by weight of CBD oil.
3. The composition according to claim 1 , consisting of from about 6% to about 15% by weight of sunflower oil.
4. A composition for treating hypertension, consisting of:
a) from about 5 mg to about 15 mg by weight of CBD oil wherein the CBD oil contains from about 80% to about 92% by weight of cannabidiol;
b) from about 5 mg to about 45 mg by weight of sunflower oil;
c) from about 1 mg to about 10 mg by weight of one or more bile salts wherein the bile salt is selected from the group consisting of deoxycholic acid, taurocholate, glycocholic acid or mixtures thereof; and
d) the balance being one or more carriers selected from the group consisting of colloidal silicon dioxide, tapioca starch, or mixtures thereof.
5. The composition according to claim 4 , wherein the composition is consisting of from 5 mg to about 12 mg by weight of CBD oil.
6. The composition according to claim 4 , consisting of from about 5 to about 30 mg by weight of sunflower oil.
7. The composition according to claim 4 , wherein the bile salt is deoxycholic acid.
8. A composition for treating hypertension, consisting of:
a) from about 10 mg to about 100 mg by weight of CBD oil;
b) from about 10 mg to about 300 mg by weight of sunflower oil;
c) from about 60 to about 70 mg by weight of one or more bile salts wherein the bile salt is selected from the group consisting of deoxycholic acid, taurocholate, glycocholic acid or mixtures thereof; and
d) from about 200 mg to about 800 mg by weight of one or more carriers wherein the carriers are selected from the group consisting of tapioca starch, tapioca flour, silicon dioxide, and mixture thereof.
9. The composition according to claim 8 , consisting of:
a) from about 25 mg to about 40 mg by weight of CBD oil;
b) from about 50 mg to about 80 mg by weight of sunflower oil;
c) from about 60 mg to about 70 mg by weight of one or more bile salts wherein the bile salt is selected from the group consisting of deoxycholic acid, taurocholate, glycocholic acid or mixtures thereof; and
d) from about 500 mg to about 600 mg by weight of one or more carriers wherein the carriers are selected from the group consisting of tapioca starch, tapioca flour, silicon dioxide, and mixture thereof.
10. The composition according to claim 8 , consisting of:
a) from about 75 mg to about 90 mg by weight of CBD oil;
b) from about 55 mg to about 70 mg by weight of sunflower oil;
c) from about 60 mg to about 70 mg by weight of one or more bile salts wherein the bile salt is selected from the group consisting of deoxycholic acid, taurocholate, glycocholic acid or mixtures thereof; and
d) from about 500 mg to about 600 mg by weight of one or more carriers wherein the carriers are selected from the group consisting of tapioca starch, tapioca flour, silicon dioxide, and mixture thereof.
11. The composition according to claim 8 , consisting of:
a) from about 80 mg to about 95 mg by weight of CBD oil;
b) from about 160 mg to about 190 mg by weight of sunflower oil;
c) from about 60 mg to about 70 mg by weight of one or more bile salts wherein the bile salt is selected from the group consisting of deoxycholic acid, taurocholate, glycocholic acid or mixtures thereof; and
d) from about 300 mg to about 400 mg by weight of one or more carriers wherein the carriers are selected from the group consisting of mannitol, silicon dioxide, colloidal silicon dioxide, microcrystalline cellulose, and mixture thereof.
12. The composition according to claim 8 , consisting of:
a) about 81 mg by weight of CBD oil;
b) about 62 mg by weight of sunflower oil;
c) about 65 mg by weight of one more bile salts wherein the bile salt is selected from the group consisting of deoxycholic acid, taurocholate, glycocholic acid or mixtures thereof; and
d) about 575 mg by weight of one or more carriers wherein the carriers are selected from the group consisting of tapioca starch, tapioca flour, silicon dioxide, and mixture thereof.
13. The composition according to claim 8 , consisting of:
a) from about 80 mg to about 95 mg by weight of CBD oil;
b) from about 160 mg to about 190 mg by weight of sunflower oil;
c) from about 60 to about 70 mg by weight of one or more bile salts wherein the bile salt is selected from the group consisting of deoxycholic acid, taurocholate, glycocholic acid or mixtures thereof; and
d) from about 300 mg to about 400 mg by weight of one or more carriers wherein the carriers are selected from the group consisting of from mannitol, silicon dioxide, colloidal silicon dioxide, microcrystalline cellulose, and mixture thereof.
14. The composition according to claim 8 , consisting of:
a) about 87 mg by weight of CBD oil;
b) about 174 mg by weight of sunflower oil;
c) about 65 mg by weight one or more bile salts wherein the bile salt is selected from the group consisting of deoxycholic acid, taurocholate, glycocholic acid or mixtures thereof; and
d) about 375 mg by weight of one or more carriers wherein the carriers are selected from the group consisting of mannitol, silicon dioxide, colloidal silicon dioxide, microcrystalline cellulose.
15. The composition according to claim 8 , consisting of:
a) from about 70 mg to about 80 mg by weight of CBD oil;
b) from about 145 mg to about 160 mg by weight of sunflower oil;
c) from about 5 mg to about 8 mg by weight of one or more bile salts wherein the bile salt is selected from the group consisting of deoxycholic acid, taurocholate, glycocholic acid or mixtures thereof; and
d) from about 300 mg to about 350 mg by weight of one or more carriers wherein the carriers are selected from the group consisting of mannitol, silicon dioxide, colloidal silicon dioxide, microcrystalline cellulose, and mixture thereof.
16. The composition according to claim 8 , consisting of:
a) about 76 mg by weight of CBD oil;
b) about 152 mg by weight of sunflower oil;
c) about 7 mg by weight of one or more bile salts wherein the bile salt is selected from the group consisting of deoxycholic acid, taurocholate, glycocholic acid or mixtures thereof; and
d) about 335 mg by weight of one or more carriers wherein the carriers are selected from the group consisting of mannitol, silicon dioxide, colloidal silicon dioxide, microcrystalline cellulose, and mixture thereof.
17. A method for treating hypertension in a subject in need of treatment, comprising administering to a subject in need an effective amount of a composition consisting of:
a) from about 0.5% to about 20% by weight of CBD oil;
b) from about 0.5% to about 60% by weight of sunflower oil; c) from about 5% to about 20% by weight of a bile salt wherein the bile salt is selected from the group consisting of deoxycholic acid, taurocholate acid, glycocholic acid, or mixtures thereof; and
(d) the balance being from about 20% to about 99% by weight of one or more carriers selected from the group consisting of colloidal silicon dioxide, tapioca starch, or mixtures thereof.
18. The method according to claim 17 , further comprising from about 5% to about 15% of a bile salt.