Compositions of matter and pharmaceutical compositions
Pharmaceutical formulations of novel indole compounds and psilocybin analogs are manufactured, provided in novel oral, transdermal, and nasal pharmaceutical compositions for use to treat neurological, mood or abuse diseases and disorders.
1. A transdermal product, comprising
an active ingredient, wherein the active ingredient is DMT or 4-AcO-DMT, wherein the active ingredient is present in an amount of about 0.01%-about 20% (w/w);
an adhesive, wherein the adhesive is present in an amount of about 20%-about 80% (w/w); and
a co-solvent, wherein the co-solvent is present in an amount of about 0%-about 20% (w/w),
wherein the transdermal product is a patch.
2. The transdermal product of claim 1 , wherein the active ingredient is present in an amount of about 4%-about 15% (w/w).
3. The transdermal product of claim 2 , wherein the transdermal product has a thickness of about 150 μm to about 250 μm.
4. The transdermal product of claim 3 , wherein the transdermal product has an average active ingredient flux of about 6 μg/cm 2 *hr-about 150 μg/cm 2 *hr over 48 hours.
5. The transdermal product of claim 4 , wherein the adhesive is selected from the group consisting of: polyisobutylene, silicone, and acrylate based adhesives.
6. The transdermal product of claim 5 , wherein the co-solvent is selected from the group consisting of: methanol, ethanol, isopropanol, ethylene glycol, polyethylene glycol, propylene glycol, dipropylene glycol, glycerol, sulfoxides, ethyl acetate, hexane, heptane, toluene, xylene, and water.
7. The transdermal product of claim 6 further comprising a permeation enhancer.
8. The transdermal product of claim 7 , wherein the permeation enhancer is selected from the group consisting of: isopropyl myristate, oleic acid, triglycerides, fatty acids, azones, phospholipids, polysorbates, and sorbitans.
9. The transdermal product of claim 8 , further comprising a tackifier.
10. The transdermal product of claim 9 , wherein the tackifier is selected from the group consisting of: gums, resins, and carbomers.
11. The transdermal product of claim 10 , wherein the adhesive is an acrylate and the permeation enhancer is isopropyl myristate.
12. The transdermal product of claim 11 further comprising an occlusive backing and a release liner, wherein the release liner is amine resistant.
13. The transdermal product of claim 1 , wherein the active ingredient is DMT.
14. The transdermal product of claim 4 , wherein the active ingredient is DMT.
15. The transdermal product of claim 8 , wherein the active ingredient is DMT.
16. The transdermal product of claim 12 , wherein the active ingredient is DMT.
17. The transdermal product of claim 1 , wherein the active ingredient is 4-AcO-DMT.
18. The transdermal product of claim 4 , wherein the active ingredient is 4-AcO-DMT.
19. The transdermal product of claim 8 , wherein the active ingredient is 4-AcO-DMT.
20. The transdermal product of claim 12 , wherein the active ingredient is 4-AcO-DMT.