COSMECEUTICAL COMPOSITION
Cosmeceutical compositions for and methods of improving the appearance of skin and promoting hair growth are provided. Said compositions comprise at least one ROS-scavenging polymer gel, at least MG53, or a combination thereof. A novel boronate ester-based copolymer forms an aqueous hydrogel exhibiting lower viscosity at cooler temperatures and higher viscosity at higher temperatures is provided.
1 ) A cosmeceutical composition comprising MG53 and one or more cosmetically acceptable excipients.
2 ) The cosmeceutical composition of claim 1 further comprising a) one or more antioxidants; b) one or more zinc salts; c) aqueous liquid vehicle; or d) a combination thereof.
3 ) The cosmeceutical composition of claim 2 , wherein a) the molar ratio of MG53 to antioxidant ranges from 0.01:1 to 10:1; b) the molar ratio of MG53 to zinc salt is about 1:2 or more; and/or c) the content of aqueous liquid vehicle is at least 30% wt.
4 ) The cosmeceutical composition of claim 1 , wherein said composition a) is adapted for topical administration, dermal administration, transdermal administration, or subcutaneous administration; and/or b) is a gel, cream, or ointment.
5 ) The cosmeceutical composition of claim 1 , wherein said composition a) is a gel comprising at least one cosmetically acceptable antioxidant polymer, an effective amount of MG53, and at least one liquid vehicle, wherein said gel exhibits a low viscosity at less than about 15° C., and said gel solidifies or semi-solidifies (thicken substantially into a high viscosity mass) after contact with skin, or after contact with a surface of at least about 18° C., at least about 20° C., or at least about 25° C.; b) is a cream comprising a cream base and an effective amount of MG53; c) is a cosmeceutical ointment comprising an ointment base and an effective amount of MG53; or d) is a hydrogel that is a liquid prior to topical application to skin and becomes a gel, semi-solid or solid after topical application to skin.
6 ) The cosmeceutical composition of claim 5 , wherein a) said cream base comprises one or more cosmetically acceptable (and/or pharmaceutically acceptable) excipients; b) said antioxidant polymer comprises ROS-scavenging copolymer; c) said hydrogel comprises boronate ester-based copolymer, said hydrogel exhibiting lower viscosity at about a lower temperature and higher viscosity at a higher temperature; and/or d) said hydrogel i) exhibits lower viscosity at about 4° C. and higher viscosity at about 37° C.; ii) is a liquid at about 4° C. and a gel, semi-solid or solid at about 37° C.; and/or iii) at about 4° C. is flowable by hand through an 18-30 gauge needle engaged to a syringe and at about 37° C. is not flowable by hand through an 18-30 gauge needle engaged to a syringe; e)
7 ) The cosmeceutical composition of claim 6 , wherein said copolymer a) is a terpolymer comprising one or more acrylamide monomer(s), one or more methacrylate monomer(s), and one or more boronate ester acrylate monomer(s); and/or b) excludes an alkyne group-containing monomer.
8 ) The cosmeceutical composition of claim 7 , wherein a) said one or more acrylamide (AM) monomer(s) refers to (N-alkyl) acrylamide (NAAM) or homolog(s) or analog(s) thereof; b) said one or more methacrylate (MAc) monomer(s) refers to (hydroxyalkyl) methacrylate (HAMc) or homolog(s) or analog(s) thereof; c) said one or more boronate ester acrylate (BEAc) monomer(s) refers to 4-(hydroxyalkyl)-phenylboronic acid, pinacol ester) acrylate (HPPE-Ac) or homolog(s) or analog(s) thereof, or d) a combination thereof.
9 ) The cosmeceutical composition of claim 8 , wherein a) said one or more acrylamide (AM) monomer(s) or homolog(s) or analog(s) is defined by the following chemical structure
wherein R is propyl, isopropyl, butyl, isobutyl or other alkyl group of 5 or less carbon atoms in length;
b) said one or more methacrylate (MAc) monomer(s) or homolog(s) or analog(s) is defined by the following chemical structure
wherein R is (CH 2 ) n ; and n=2, 3, or 4; and/or
c) said one or more boronate ester acrylate ester (BEAc) monomer(s) or homolog(s) or analog(s) is defined by the following chemical structure
10 ) The cosmeceutical composition of claim 9 , wherein alkyl is independently selected upon each occurrence from the group consisting of (C 1 -C 2 )-alkyl or (C 3 -C 8 )-alkyl, which alkyl may be linear, branched, or cyclic.
11 ) The cosmeceutical composition of claim 6 , wherein said terpolymer is defined by the formula
poly((AM) m -co-(MAc) n -co-(BEAc) x ), a)
wherein: m is in the range of about 75 to about 85, n is in the range of about 5 to about 20, and x is in the range of about 5 to about 20;
poly((NAAM) m -co-(HAMAc) n -co-(HPPE-Ac) x ) b)
wherein: m is in the range of about 75 to about 85, n is in the range of about 5 to about 20, and x is in the range of about 5 to about 20; or
poly((NIPAA) m -co-(HEMA) n -co-(AIPPE)x), c)
wherein NIPAAM is N-isopropylacrylamide, HEMA is hydroxyethyl methacrylate, AHPPE is (4-(hydroxymethyl)-phenylboronic acid, pinacol ester) acrylate (or 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl ester).
12 ) A method of improving the appearance of skin by administering to the skin a cosmetically effective amount of the cosmeceutical composition of claim 1 .
13 ) The method of claim 12 , wherein said improving is selected from the group consisting of reducing wrinkles, reducing melanin deposition, reducing irritation, reducing inflammation, reducing redness, reducing scarring, reducing collagen formation, reducing differentiation of stem cells into fibroblasts, reducing the period of time for amelioration of dermal of epidermal condition(s).
14 ) A method of preventing reactive oxygen species (ROS)-related oxidative damage to skin, said method comprising prophylactically administering to the skin a cosmetically effective amount of the cosmeceutical composition of claim 1 prior to exposure of said skin to the ROS.
15 ) A method of sequestering, neutralizing or eliminating reactive oxygen species (ROS) in skin comprising administering to the skin a cosmetically effective amount of the cosmeceutical composition of claim 1 after exposure of said skin to the ROS.
16 ) A method of improving hair growth, the method comprising administering to the skin of a subject in need thereof a cosmetically effective amount of the cosmeceutical composition of claim 1 .
17 ) The method of claim 16 , wherein said improving hair growth includes at least one of increasing hair strand thickness, improving hair follicle health, increasing the number of hair follicles per unit area of skin, or increasing rate of hair growth.
18 ) A method of removing skin blemishes or improving the appearance of skin blemishes, the method comprising administering to the skin of a subject in need thereof a cosmetically effective amount of the cosmeceutical composition of claim 1 , wherein said removing or improving the appearance of skin blemishes comprises reducing the appearance or number of wrinkle(s), reducing the appearance or number of blotch(es), reducing melanin deposition, and/or reducing the appearance or number of reddened patch(es).
19 ) A method of healing injured tissue, the method comprising administering to injured tissue an effective amount of the cosmeceutical composition of claim 1 , wherein the skin has not been physically injured, such as by impact force, burning, irradiation, or cutting, and/or the skin is otherwise healthy except for exhibiting cosmetically undesired features.
20 ) Method of treating a healed wound comprising administering to said healed wound, the cosmeceutical composition of claim 1 , whereby said administering results in reduction of collagen formation at the site of said healed wound, and/or increase of follicle density at the site of said healed wound.