Preservative-free single dose inhaler systems
An aerosolization system includes a container that is configured to deliver a unit dosage of a liquid when squeezed a single time. The system also includes an aerosolizer that is constructed of a housing defining a mouthpiece, and an aerosol generator disposed in the housing. The aerosol generator includes a vibratable membrane having a front face and a rear face, and a vibratable element used to vibrate the membrane. Further, the housing includes an opening that is adapted to receive a unit dosage of the liquid from the container. The opening provides a liquid path to the rear face of the vibratable membrane.
1. A method of aerosolizing a volume of liquid medicament, comprising:
providing an inhaler, comprising:
a housing comprising a mouthpiece and a liquid receptacle fluidly coupled to the mouthpiece, wherein the liquid receptacle defines an opening that extends through an exterior surface of the housing at an inlet end of the opening;
an aerosol generator disposed within the housing, the aerosol generator comprising:
a membrane having a front face, a rear face, and a plurality of apertures that extend between the front face and the rear face; and
a vibratable element; and
a visual indicator, wherein an inlet end of the opening is positioned between, and in general alignment with, the mouthpiece and the visual indicator, with the visual indicator and the opening being positioned on a same surface of the housing and the visual indicator being oriented such that the visual indicator is visible to a user of the inhaler while the user inhales through the mouthpiece;
detecting fluid flow through the mouthpiece as the user inhales using a flow sensor;
activating the vibratable element in response to detecting the fluid flow to aerosolize a dosage of the liquid medicament that has been supplied to the rear face of the membrane as the user inhales via the mouthpiece; and
providing, using the visual indicator, an indication that the entire dosage of liquid has been aerosolized.
2. The method of aerosolizing a volume of liquid medicament of claim 1 , further comprising:
providing, using the visual indicator, an indication that the dosage of liquid medicament has been received within a receiving chamber within the housing.
3. The method of aerosolizing a volume of liquid medicament of claim 2 , wherein:
the visual indicator comprises a first light that provides the indication that the dosage of liquid medicament has been received within the receiving chamber and a second light that provides the indication that the entire dosage of liquid has been aerosolized.
4. The method of aerosolizing a volume of liquid medicament of claim 3 , wherein:
providing the indication that the dosage of liquid medicament has been received within the receiving chamber comprises blinking the first light.
5. The method of aerosolizing a volume of liquid medicament of claim 1 , wherein:
the housing comprises a funnel coupled with the opening, the funnel directing the liquid medicament to the rear face of the membrane.
6. The method of aerosolizing a volume of liquid medicament of claim 5 , wherein:
a slope of the funnel is at least 30 degrees relative to a central axis of the opening.
7. A method of aerosolizing a volume of liquid medicament, comprising:
providing an indication that a dosage of the liquid medicament has been received by an inhaler via an opening formed through a housing of the inhaler;
detecting fluid flow through a mouthpiece of the inhaler as a user inhales through the mouthpiece using a flow sensor of the inhaler;
activating an aerosol generator of the inhaler in response to detecting the fluid flow to aerosolize the dosage of liquid medicament that has been supplied to a rear face of a membrane of the aerosol generator as the user inhales via the mouthpiece; and
providing an indication that the entire dosage of liquid has been aerosolized using a visual indictor of the inhaler, wherein an inlet end of the opening is positioned between, and in general alignment with, the mouthpiece and the visual indicator, with the visual indicator and the opening being positioned on a same surface of the housing and the visual indicator being oriented such that the visual indicator is visible to the user while the user inhales through the mouthpiece.
8. The method of aerosolizing a volume of liquid medicament of claim 7 , wherein:
the visual indicator is positioned in alignment with a center of the mouthpiece along a central axis of the inhaler.
9. The method of aerosolizing a volume of liquid medicament of claim 7 , wherein:
the inhaler comprises a funnel that directs the dosage of liquid medicament to the rear face of the membrane.
10. The method of aerosolizing a volume of liquid medicament of claim 9 , wherein:
the funnel comprises a maximum diameter of between about 10 mm and 15 mm and an opening to the funnel is at least 5 mm.
11. The method of aerosolizing a volume of liquid medicament of claim 7 , wherein:
the aerosol generator comprises a vibratable element that vibrates the membrane.
12. The method of aerosolizing a volume of liquid medicament of claim 11 , wherein:
the vibratable element vibrates at a rate of between about 50 kHz to 150 kHz.
13. The method of aerosolizing a volume of liquid medicament of claim 7 , wherein:
delivery of the entire dosage comprises delivery of 98% or more of the liquid medicament received by the inhaler.
14. A method of aerosolizing a volume of liquid medicament, comprising:
detecting fluid flow through a mouthpiece of an inhaler as a user inhales through the mouthpiece using a flow sensor of the inhaler;
activating an aerosol generator of the inhaler in response to detecting the fluid flow to aerosolize a dosage of the liquid medicament that has been supplied to the aerosol generator via an opening formed through a housing of the inhaler as the user inhales via the mouthpiece; and
providing an indication that the entire dosage of liquid has been aerosolized using a visual indictor of the inhaler, wherein an inlet end of the opening is positioned between, and in general alignment with, the mouthpiece and the visual indicator, with the visual indicator and the opening being positioned on a same surface of the housing and the visual indicator being oriented such that the visual indicator is visible to the user while the user inhales through the mouthpiece.
15. The method of aerosolizing a volume of liquid medicament of claim 14 , wherein:
activating the aerosol generator comprises vibrating a vibratable member that is coupled with a dome-shaped membrane.
16. The method of aerosolizing a volume of liquid medicament of claim 14 , wherein:
the visual indicator comprises at least one light.
17. The method of aerosolizing a volume of liquid medicament of claim 14 , wherein:
an exterior housing of the inhaler defines the opening through which the liquid medicament is delivered to the aerosol generator; and
the opening and the visual indicator are disposed on a same wall of the exterior housing.
18. The method of aerosolizing a volume of liquid medicament of claim 14 , further comprising:
providing an indication that the dosage of liquid medicament has been received by the inhaler.