PARAXANTHINE-BASED CAFFEINE SUBSTITUTE COMPOSITIONS AND METHOD OF USE THEREOF IN SLOW CAFFEINE METABOLIZERS
The disclosed compositions methods relate to a dietary supplement for subjects with slow caffeine metabolism and comprises paraxanthine and optionally other compounds that modulate the effects of paraxanthine. Uses for the paraxanthine-containing supplements contain improvement of at least one of endurance performance, mood, vigor, lipolysis, energy expenditure, exercise performance, and/or decreased appetite in a slow caffeine metabolizer subject.
1 . A method for improving cognitive function in a slow caffeine metabolizer (SCM) subject, comprising:
a. identifying an individual as a SCM subject; and
b. providing the SCM subject with a composition comprising about 2 mg to about 800 mg of paraxanthine.
2 . The method of claim 1 , wherein the step of identifying the SCM subject comprises genotyping the individual for a genetic variant associated with slow caffeine metabolism.
3 . The method of claim 2 , wherein the genetic variant is in a CYP1A2, ADORA2A and/or CYP2E1 gene.
4 . The method of claim 3 , wherein the genetic variant is in the CYP1A2 gene and the subject’s genotype is AC or CC.
5 . The method of claim 2 , wherein the SCM subject is identified by administering the individual a questionnaire on the individual’s response to caffeine.
6 . The method of claim 1 , wherein the SCM subject self-diagnoses as SCM.
7 . The method of claim 1 , wherein the step of identifying the SCM subject comprises measuring the individual’s rate of caffeine metabolism.
8 . The method of claim 1 , wherein improved cognitive function is measured by an increase in one or more of: attention, information acquisition, information processing, working memory, short-term memory, long-term memory, anterograde memory, retrograde memory, memory retrieval, discrimination learning, decision-making, inhibitory response control, attentional setshifting, delayed reinforcement learning, reversal learning, the temporal integration of voluntary behavior, speed of processing, reasoning, problem solving and/or social cognition in the SCM subject.
9 . The method of claim 1 , wherein the composition further comprises at least one agent selected from 1-methylxanthine and/or 7-methylxanthine.
10 . The method of claim 9 , wherein the 1-methylxantine and/or 7-methylxantine are present in the composition in an amount from about 50 mg to about 400 mg.
11 . The method of claim 1 , wherein administration of the composition to the SCM subject increases serum Brain Derived Neurotrophic Factor (BDNF) concentration of at least about 10% relative to a fast caffeine metabolizer subject who received a comparable dose of the composition.
12 . The method of claim 1 , wherein the composition further comprises at least one ingredient selected from the group consisting tyrosine, N-acetyl-tyrosine, taurine, huperzine A, acetyl-1-carnitine, CDP choline, Alpha GPC, choline bitrate, choline citrate, B 12, caffeine, methyllliberine, theacrine, paraxanthine, theobromine, ashwagandha, rhodiola, lutein, zeaxanthin, fish oil, creatine, ginseng, lions mane, niacin, cordyceps, theanine, B-vitamins, GABA, sulbutiamine, vinpocetine, adenosine triphosphate, inositol, enhanced arginine silicate, nitrates, electrolytes, hesperidin and derivatives of hesperidin and/or bacopa.
13 . A method for improving athletic performance in a SCM subject in comprising administering to the subject a composition comprising an effective amount of paraxanthine.
14 . The method of claim 13 , wherein the amount of paraxanthine is administered is from about 50 mg to about 400 mg.
15 . The method of claim 14 , wherein the subject experiences and increase in endurance.
16 . The method of claim 13 wherein the composition further comprises 1-methylxanthine in an amount from about 2 mg to about 800 mg and wherein administration of the composition to a subject produces a synergistic increase in athletic performance to the administration of a comparable dose of paraxanthine or 1-methylxanthine alone.
17 . The method of claim 13 , wherein administration of the composition to the SCM subjectincreases serum N-methylnicotinamide (MNA) concentration from about 20-100% relative to the change in the subject following administration of a comparable dose of caffeine.
18 . A method of promoting weight loss in a SCM subject comprising:
a. identifying an individual as a SCM subject; and
b. providing the SCM subject with a composition comprising about 2 mg to about 800 mg of paraxanthine.
19 . The method of claim 18 , wherein weight loss is promoted through inducing thermogenesis in the subject.
20 . The method of claim 19 , wherein the composition further comprises one or more compounds selected from a list consisting of: caffeine, green tea, capsaicin, garcinia cambogia, yohimbine and bitter orange.
21 . The method of claim 18 , wherein administration of the composition to the SCM subject increases serum N-methylnicotinamide (MNA) concentration from about 20-100% relative to the change in the subject following administration of a comparable dose of caffeine and wherein the subject experiences an increased perception of energy and/or a decreased perception of jitteriness.
22 . The method of claim 18 , wherein weight loss is promoted through enhancing lipolysis in the subject.