IP Library › Granted Patent US 12,384,762
Granted Patent B2
US 12,384,762 · App. 17/880,720 · Granted Aug 12, 2025

Modulator of the Cystic Fibrosis Transmembrane Conductance Regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator

Inventors: Alexander Russell Abela (San Diego, CA); Timothy Alcacio (San Diego, CA); Corey Anderson (San Diego, CA); Paul Timothy Angell (Carlsbad, CA); Minson Baek (San Diego, CA); Jeremy J. Clemens (San Diego, CA); Thomas Cleveland (San Marcos, CA); Lori Ann Ferris (Wilmington, MA); Peter Diederik Jan Grootenhuis (Del Mar, CA); Raymond Stanley Gross (Poway, CA); Anton V. Gulevich (San Diego, CA); Sara Sabina Hadida Ruah (La Jolla, CA); Clara Kuang-Ju Hsia (San Diego, CA); Robert M. Hughes (San Diego, CA); Pramod Virupax Joshi (San Diego, CA); Ping Kang (San Diego, CA); Ali Keshavarz-Shokri (San Diego, CA); Haripada Khatuya (San Diego, CA); Paul John Krenitsky (San Diego, CA); Jason McCartney (Cardiff by the Sea, CA); Mark Thomas Miller (San Diego, CA); Prasuna Paraselli (San Diego, CA); Fabrice Jean Denis Pierre (La Jolla, CA); Yi Shi (Natick, MA); Muna Shrestha (Belmont, MA); David Andrew Siesel (San Diego, CA); Kathy Stavropoulos (Quincy, MA); Andreas P. Termin (Encinitas, CA); Fredrick F. Van Goor (San Diego, CA); Johnny Uy (San Diego, CA); Timothy John Young (San Diego, CA); Jinglan Zhou (San Diego, CA)
Assignee: Vertex Pharmaceuticals Incorporated
C07D401/14A61P11/00C07D231/20C07D401/04C07D471/14C07D498/14C07B2200/13
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Quick Facts
Patent No.
US 12,384,762
App. No.
17/880,720
Granted
Aug 12, 2025
Kind
B2
Abstract

Compounds of Formula (I): pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.

Claims (4)

1. A solid dispersion comprising Compound 1:

and a polymer.

2. The solid dispersion of claim 1 , comprising 50 wt % of Compound 1 and 50 wt % of a polymer by the total weight of the solid dispersion or 80 wt % of Compound 1 and 20 wt % of a polymer by the total weight of the solid dispersion.

3. The solid dispersion of claim 1 , wherein the polymer is a hypromellose acetate succinate, hydroxypropyl cellulose, hydroxypropyl methylcellulose, or Polyvinylpyrrolidone.

Assignments (4)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 28, 2023
From: VERTEX PHARMACEUTICALS (SAN DIEGO) LLC
To: VERTEX PHARMACEUTICALS INCORPORATED
Reel/Frame 065972/0539 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 28, 2023
From: KHATUYA, HARIPADA; PIERRE, FABRICE JEAN DENIS; ABELA, ALEXANDER RUSSELL; GULEVICH, ANTON V.; PARASELLI, PRASUNA; FERRIS, LORI ANN; STAVROPOULOS, KATHY; SHI, YI; SHRESTHA, MUNA
To: VERTEX PHARMACEUTICALS INCORPORATED
Reel/Frame 065972/0543 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 28, 2023
From: BAEK, MINSON; MCCARTNEY, JASON; ANDERSON, COREY; JOSHI, PRAMOD VIRUPAX; CLEMENS, JEREMY J.; CLEVELAND, THOMAS; GROSS, RAYMOND STANLEY; KRENITSKY, PAUL JOHN; TERMIN, ANDREAS P.; UY, JOHNNY; ZHOU, JINGLAN; KANG, PING; HSIA, CLARA KUANG-JU
To: VERTEX PHARMACEUTICALS (SAN DIEGO) LLC
Reel/Frame 065972/0567 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 28, 2023
From: ALCACIO, TIMOTHY; ANGELL, PAUL TIMOTHY; GROOTENHUIS, PETER DIEDERIK JAN; HADIDA RUAH, SARA SABINA; HUGHES, ROBERT M.; MILLER, MARK THOMAS; KESHAVARZ-SHOKRI, ALI; SIESEL, DAVID ANDREW; VAN GOOR, FREDRICK F.; YOUNG, TIMOTHY JOHN
To: VERTEX PHARMACEUTICALS (SAN DIEGO) LLC
Reel/Frame 065972/0655 →
Continuity (4)
Division 16994875 · Aug 17, 2020
Division 15836627 · Dec 8, 2017
Provisional Application 62432537 · Dec 9, 2016
Related Publication 20230357191A1 · Nov 9, 2023
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