IP Library › Granted Patent US 12,383,143
Granted Patent B2
US 12,383,143 · App. 17/886,086 · Granted Aug 12, 2025

Feedback detection for a treatment device

Inventors: Jayant Bhawalkar (Auburndale, MA); Charles Holland Dresser (Wayland, MA); Rajender Katkam (Boston, MA)
Assignee: Avava, Inc.
A61B5/0068A61B5/0064A61B5/4836A61B5/742A61B18/201A61B18/203A61B90/20A61N1/44A61N5/0616A61B5/443A61B2017/00057A61B2017/0019A61B2018/00458A61B2018/00642A61B2018/00904A61B2018/202A61B2018/20355A61B2018/20361A61N2005/0644H05H1/46
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 12,383,143
App. No.
17/886,086
Granted
Aug 12, 2025
Kind
B2
Abstract

A system includes a focus optic configured to converge an electromagnetic radiation (EMR) beam to a focal region located along an optical axis. The system also includes a detector configured to detect a signal radiation emanating from a predetermined location along the optical axis. The system additionally includes a controller configured to adjust a parameter of the EMR beam based in part on the signal radiation detected by the detector. The system also includes a window located a predetermined depth away from the focal region, between the focal region and the focus optic along the optical axis, wherein the window is configured to make contact with a surface of a tissue.

Claims (28)

1. A method of treatment, comprising:

imaging a target tissue with imaging radiation delivered along an optical pathway to create a signal radiation emanating from the target tissue, the signal radiation generated by plasma formed in the target tissue through interaction with the imaging radiation;

scanning the imaging radiation along the optical axis to alter characteristics of the signal radiation;

determining one or more aspects of the target tissue based on the altered signal radiation;

receiving, from a controller in electrical communication with the optical pathway and based on the determined one or more aspects of the target tissue, one or more suggested changes to a set of baseline parameters of a treatment radiation;

adjusting, based on the received one or more suggested changes, the set of baseline parameters to result in an adjusted treatment radiation; and

emitting the adjusted treatment radiation delivered along the optical pathway to treat the target tissue.

2. The method of claim 1 , wherein the one or more aspects include at least one of a location of a pigment, a proportion of melanin, and a depth of a dermal-epidermal layer junction.

3. The method of claim 1 , wherein the imaging radiation and the treatment radiation have the same wavelength.

4. The method of claim 1 , wherein the adjusted set of baseline parameters includes a location of a focal region within the tissue.

5. The method of claim 1 , wherein the baseline parameters include at least one of a focal depth, a wavelength, a polarization, and an intensity.

6. The method of claim 1 , wherein the imaging comprises at least one of microscopic imaging, wide field of view imaging, reflectance confocal imaging, optical coherence tomography imaging, optical coherence elastography imaging, coherent anti-stokes Raman spectroscopy imaging, two-photon imaging, second harmonic generation imaging, phase conjugate imaging, photoacoustic imaging, infrared spectral imaging, and hyperspectral imaging.

7. The method of claim 1 , wherein the target tissue comprises skin afflicted with at least one of post inflammatory hyperpigmentation (PIH), dark skin surrounding eyes, dark eyes, café au lait patches, Becker's nevi, Nevus of Ota, congenital melanocytic nevi, ephelides (freckles) and lentigo.

8. A method of treatment, comprising:

irradiating a target tissue with an imaging EMR beam delivered along an optical pathway to image the target tissue;

detecting at least a portion of a signal radiation caused by the imaging EMR beam reflecting off of the target tissue and by plasma generated in the target tissue;

scanning the imaging EMR beam along the optical pathway to adjust characteristics of the signal radiation;

determining one or more aspects of the target tissue based on the adjusted characteristics of the signal radiation;

receiving, from a controller and based on the determined one or more aspects of the target tissue, one or more recommended adjustments to parameters of a treatment EMR beam;

adjusting the parameters of the treatment EMR beam based on the one or more recommended adjustments; and

irradiating a target tissue with the adjusted treatment EMR beam delivered along the optical pathway to treat the target tissue.

9. The method of claim 8 , wherein the one or more aspects include at least one of a proportion and a distribution of melanin in the target tissue.

10. The method of claim 9 , wherein the one or more parameters include energy per pulse, focus angle, and depth of a focal region of the treatment EMR beam.

11. The method of claim 9 , further comprising:

generating a map of the one or more aspects of the target tissue; and

varying the adjusted treatment radiation based on the generated map.

12. The method of claim 9 , further comprising:

recommending, based at least partially on at least one of the proportion and the distribution of melanin in the target tissue, one or more changes to the one or more parameters of the treatment EMR beam to a designated personnel.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 19, 2024
From: AVAVA, INC.
To: ANKURA TRUST COMPANY, LLC
Reel/Frame 066181/0390 →
Continuity (5)
Continuation 16447941 · Jun 20, 2019
Provisional Application 62688913 · Jun 22, 2018
Provisional Application 62688940 · Jun 22, 2018
Provisional Application 62688855 · Jun 22, 2018
Related Publication 20230107384A1 · Apr 6, 2023
References Cited (69)
US 5446538A · Noll · 1995 [cited by applicant]
US 5995867A · Zavislan · 1999 [cited by examiner]
US 6044288A · Wake et al. · 2000 [cited by applicant]
US 6074382A · Asah et al. · 2000 [cited by applicant]
US 6165170A · Wynne et al. · 2000 [cited by applicant]
US 7282060B2 · Debenedictis et al. · 2007 [cited by applicant]
US 8523926B2 · Neev · 2013 [cited by applicant]
US 9414888B2 · Liu et al. · 2016 [cited by applicant]
US 9486284B2 · Depfenhart et al. · 2016 [cited by applicant]
US 11457816B2 · Bhawalkar et al. · 2022 [cited by applicant]
US 20050154380A1 · Debenedictis et al. · 2005 [cited by applicant]
US 20060084957A1 · Delfyett et al. · 2006 [cited by applicant]
US 20060106371A1 · Muhlhoff et al. · 2006 [cited by applicant]
US 20060217691A1 · Schuele et al. · 2006 [cited by applicant]
US 20070173791A1 · Raksi · 2007 [cited by applicant]
US 20080033406A1 · Angeley et al. · 2008 [cited by applicant]
US 20080306471A1 · Altshuler et al. · 2008 [cited by applicant]
US 20090248004A1 · Altshuler et al. · 2009 [cited by applicant]
US 20100130969A1 · Batterson et al. · 2010 [cited by applicant]
US 20110022039A1 · Spikker et al. · 2011 [cited by applicant]
US 20110100967A1 · Yoo et al. · 2011 [cited by applicant]
US 20140005756A1 · Liu et al. · 2014 [cited by applicant]
US 20140094711A1 · Sondermann et al. · 2014 [cited by applicant]
US 20140128853A1 · Angeley · 2014 [cited by examiner]
US 20140288621A1 · Efremkin · 2014 [cited by applicant]
US 20140364744A1 · Wellhoefer · 2014 [cited by examiner]
US 20160074116A1 · Varghese et al. · 2016 [cited by applicant]
US 20160199132A1 · Anderson et al. · 2016 [cited by applicant]
US 20160249982A1 · Varghese et al. · 2016 [cited by applicant]
US 20160256324A1 · Suzuki · 2016 [cited by applicant]
US 20160278981A1 · Kempe · 2016 [cited by examiner]
US 20160317226A1 · Jagdeo · 2016 [cited by examiner]
US 20170151330A1 · Harris et al. · 2017 [cited by applicant]
US 20170247797A1 · Zhou et al. · 2017 [cited by applicant]
US 20170281077A1 · Pyun · 2017 [cited by examiner]
US 20170281405A1 · Ha · 2017 [cited by applicant]
US 20180049689A1 · Chung · 2018 [cited by examiner]
US 20180085004A1 · Pyun · 2018 [cited by examiner]
US 20180177550A1 · Anderson · 2018 [cited by examiner]
US 20180325593A1 · McMillan · 2018 [cited by examiner]
US 20200038678A1 · Holmes · 2020 [cited by examiner]
US 20210052212A1 · Yaroslavsky · 2021 [cited by examiner]
US 20210212568A1 · Bhawalkar et al. · 2021 [cited by applicant]
CN 101677835A · 2010 [cited by applicant]
CN 203971205U · 2014 [cited by applicant]
CN 107267964A · 2017 [cited by applicant]
JP 2007531558A · 2007 [cited by applicant]
JP 2007532225A · 2007 [cited by applicant]
JP 2008100057A · 2008 [cited by applicant]
JP 2008284382A · 2008 [cited by applicant]
JP 2010535556A · 2010 [cited by applicant]
JP 2015134228A · 2015 [cited by applicant]
JP 2016190090A · 2016 [cited by applicant]
JP 2016539665A · 2016 [cited by applicant]
JP 2017131303A · 2017 [cited by applicant]
JP 2020503108A · 2020 [cited by applicant]
JP 2020503119A · 2020 [cited by applicant]
WO 2014146029A1 · 2014 [cited by applicant]
WO 2015021462A1 · 2015 [cited by applicant]
WO 2018029196A1 · 2018 [cited by applicant]
WO 2018115415A1 · 2018 [cited by applicant]
Extended European Search Report Corresponding to European Patent Application No. EP19822533.6, mailed on Mar. 31, 2022, 7 pages. [cited by applicant]
International Search Report and Written Opinion for corresponding International Application No. PCT/US2019/038348, mailed on Oct. 3, 2019, 8 pages. [cited by applicant]
Chung et al. (2009) “Surgical Applications of Femtosecond Lasers”, Journal of biophotonics, 2(10):557-572. [cited by applicant]
Han et al. (2015) “Differentiation of Cutaneous Melanoma from Surrounding Skin Using Laser-Induced Breakdown Spectroscopy”, Biomed Opt Express, 7(1):57-66. [cited by applicant]
Kim et al. (2020) “Laser-Induced Optical Breakdown Effects Of Micro-Lens Arrays And Diffractive Optical Elements On Ex Vivo Porcine Skin After 1064 Nm Picosecond Laser Irradiation”, Biomed Opt Express, 11(12):7286-7296. [cited by applicant]
Roberts, Joan E. (2016) “Photobiology of the Human Lens”, https://web.archive.org/web/20160106212227/, 15 pages. [cited by applicant]
Vogel et al. (1994) “Intraocular Photodisruption With Picosecond and Nanosecond Laser Pulses: Tissue Effects in Cornea, Lens, and Retina”, Investigative Ophthalmology & Visual science, 35(7):3032-3044. [cited by applicant]
Xie et al. (Dec. 10, 2009) “Measurement of Optical Properties of Biological Tissue Based on Scanning Photoacoustic Technology”, Lasers and Optoelectronics, 103-107. [cited by applicant]