MULTIVARIATE SPIROMETER, ASSOCIATED SYSTEMS AND METHODS
A multivariate spirometer and associated systems and methods are described. The spirometer has a housing defining a flow path and one or more sensors for detecting CO 2 concentration values, temperature and/or flow rates of air in the flow path. The spirometer may be configured to generate time series data by sampling CO 2 concentration values, temperature and/or flow rates at a predetermined frequency during inhalation and/or exhalation. Optionally, a processor is used to generate one or more output readings based on the CO 2 concentration values, temperatures and/or flow rates.
1 . A spirometer comprising:
a housing comprising a first opening in fluid communication with a second opening, the first opening and second opening defining a flow path;
one or more sensors selected from the group of:
a carbon dioxide (CO 2 ) sensor for detecting CO 2 concentration values of air in the flow path;
a temperature sensor for detecting temperature of air in the flow path; and
a flow sensor for determining flow rates of air in the flow path.
2 . The spirometer of claim 1 , comprising:
two or more sensors selected from the group of:
the carbon dioxide (CO 2 ) sensor for detecting CO 2 concentration values of air in the flow path;
the temperature sensor for detecting temperature of air in the flow path; and
the flow sensor for determining flow rates of air in the flow path.
3 . The spirometer of claim 2 , comprising:
the carbon dioxide (CO 2 ) sensor for detecting CO 2 concentration values of air in the flow path;
the temperature sensor for detecting temperature of air in the flow path; and
the flow sensor for determining flow rates of air in the flow path.
4 . The spirometer of claim 3 , wherein the flow path is linear.
5 . The spirometer of claim 3 , where the flow path is non-linear.
6 . The spirometer of claim 4 , wherein the one or more sensors detect a plurality of CO 2 concentration values, a plurality of temperatures and/or a plurality of flow rates during inhalation of air by a subject through the flow path.
7 . The spirometer of claim 4 , wherein the one or more sensors detect a plurality of CO 2 concentration values, a plurality of temperatures and/or a plurality of flow rates during exhalation of air by a subject through the flow path.
8 . The spirometer of claim 7 , wherein the one or more sensors detects the plurality of CO 2 concentration values, the plurality of temperatures, and/or the plurality of flow rates as the subject continuously breathes through the flow path.
9 . The spirometer of claim 8 , wherein the first opening is configured to detachably receive a mouthpiece.
10 . The spirometer of claim 9 , wherein the mouthpiece is shaped to form a substantially airtight seal with the lips of a subject using the spirometer.
11 . The spirometer of claim 10 , wherein the mouthpiece has a circular or oval cross section.
12 . The spirometer of claim 11 , wherein the mouthpiece is made of a plastic material that is biodegradable at a temperature above 50 degrees Celsius.
13 . The spirometer of claim 12 further comprising a laminarization means disposed between the first opening and the second opening in order to produce a laminar airflow through the flow path.
14 . The spirometer of claim 12 , wherein the temperature sensor comprises a temperature sensing member in the flow path proximate to the first opening relative to the CO 2 sensor or the flow sensor, optionally relative to a CO 2 sensing member or a flow sensing member.
15 . The spirometer of claim 14 , wherein the one or more sensors detect CO 2 concentration values, temperatures and/or flow rates at a predetermined frequency of at least 3, 4, 5, 6, 7, 8, 9, 10, 20, 25, 30, 40 or 50 times per second.
16 . The spirometer of claim 15 , wherein the temperature sensor has a resolution of at least 0.5, 0.25, 0.1, 0.08, 0.06, 0.05 or 0.04 degrees Celsius.
17 . The spirometer of claim 16 , wherein the flow sensor is a bidirectional flow sensor.
18 . The spirometer of claim 1 , wherein:
the carbon dioxide (CO 2 ) sensor comprises a metal oxide gas sensor for detecting volatile organic compounds (VOCs), optionally an ams® Digital Gas Sensor;
the temperature sensor comprises a band gap temperature sensor; and/or
the flow sensor comprises thermal mass flow sensor element.
19 . The spirometer of claim 1 , further comprising:
a real-time clock; and
wherein the one or more sensors generate a plurality of sensor readings timestamped with an output of the real-time clock.
20 . The spirometer of claim 1 , further comprising:
a processor for generating one or more output readings based on the one or more CO 2 concentration values, temperatures and/or flow rates detected by the one or more sensors.
21 . The spirometer of claim 20 , further comprising:
memory for storing the one or more CO 2 concentration values, temperatures and/or flow rates detected by the one or more sensors, optionally for storing the one or more output readings.
22 . The spirometer of claim 21 , further comprising a display for presenting the output readings to a user.