IP Library Granted Patent US 12,210,079
Granted Patent B2
US 12,210,079 · App. 17/905,721 · Granted Jan 28, 2025

Phase encoding with frequency sweep pulses for magnetic resonance imaging in inhomogeneous magnetic fields

Inventors: Muller Francis De Matos Gomes (Hayward, CA); Aleksandar Nacev (San Francisco, CA)
Assignee: Promaxo, Inc.
G01R33/4835A61B5/055G01R33/3808G01R33/385
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Quick Facts
Patent No.
US 12,210,079
App. No.
17/905,721
Granted
Jan 28, 2025
Kind
B2
Abstract

Single-sided MRI apparatuses, systems, and methods are disclosed. A method can include transmitting a frequency sweep excitation pulse comprising a low-to-high frequency sweep; phase encoding during the frequency sweep excitation pulse; and tuning the amount of phase accumulated during the frequency sweep excitation pulse from adjacent slices in the slab. The frequency sweep excitation pulse can be a chirp pulse. Encoding in this way can prevent spin echoes from drifting and prevent k-space truncation in certain instances. Moreover, the resultant images can be combined more efficiently.

Claims (40)

1. A method of imaging a slab having at least two slices with a single-sided magnetic imaging apparatus, wherein an inherent gradient magnetic field extends from the magnetic imaging apparatus into a field of view, the method comprising:

transmitting a frequency sweep excitation pulse via the magnetic imaging apparatus, wherein the frequency sweep excitation pulse comprises a low-to-high frequency sweep;

phase encoding during the frequency sweep excitation pulse;

tuning the amount of phase accumulated during the frequency sweep excitation pulse from adjacent slices in the slab, wherein the tuning is performed by the magnetic imaging apparatus;

wherein the adjacent slices comprise a proximal slice and a distal slice, wherein the proximal slice is positioned closer to the magnetic imaging apparatus than the distal slice, and wherein a target in the distal slice is excited before a target in the proximal slice; and

collecting images of the adjacent slices with the magnetic imaging apparatus to generate the slab;

wherein the method is configured to compensate for the inherent gradient magnetic field such that the target in the distal slice accumulates the same phase as the target in the proximal slice.

2. A magnetic imaging apparatus, comprising:

a permanent magnet;

a gradient coil set;

an electromagnet;

a radio frequency coil, wherein an inherent gradient magnetic field extends from the magnetic imaging apparatus relative to a first axis into the field of view, wherein the first axis is perpendicular to the permanent magnet; and

a control circuit configured for imaging a slab having at least two slices, wherein the imaging comprises:

transmitting a frequency sweep excitation pulse comprising a low-to-high frequency sweep;

phase encoding during the frequency sweep excitation pulse;

tuning the amount of phase accumulated during the frequency sweep excitation pulse from adjacent slices in the slab; and

collecting images of the adjacent slices to generate the slab;

wherein (i) a different amount of phase is applied to different frequencies or (ii) the phase encoding during the frequency sweep excitation pulse prevents an echo from drifting outside of an acquisition window.

3. A method of imaging a slab having at least two slices with a single-sided magnetic imaging apparatus, wherein an inherent gradient magnetic field extends from the magnetic imaging apparatus into a field of view, the method comprising:

transmitting a frequency sweep excitation pulse via the magnetic imaging apparatus, wherein the frequency sweep excitation pulse comprises a low-to-high frequency sweep;

phase encoding during the frequency sweep excitation pulse

tuning the amount of phase accumulated during the frequency sweep excitation pulse from adjacent slices in the slab, wherein the tuning is performed by the magnetic imaging apparatus; and

collecting images of the adjacent slices to generate the slab;

wherein a different amount of phase is applied to different frequencies in the frequency sweep.

4. A method of imaging a slab having at least two slices with a single-sided magnetic imaging apparatus, wherein an inherent gradient magnetic field extends from the magnetic imaging apparatus into a field of view, the method comprising:

transmitting a frequency sweep excitation pulse via the magnetic imaging apparatus, wherein the frequency sweep excitation pulse comprises a low-to-high frequency sweep;

phase encoding during the frequency sweep excitation pulse, wherein the phase encoding during the frequency sweep excitation pulse prevents an echo from drifting outside of an acquisition window

tuning the amount of phase accumulated during the frequency sweep excitation pulse from adjacent slices in the slab, wherein the tuning is performed by the magnetic imaging apparatus; and

collecting images of the adjacent slices to generate the slab.

5. The method of claim 1 , wherein a different amount of phase is applied to different frequencies in the frequency sweep.

6. The method of claim 1 , wherein the phase encoding during the frequency sweep excitation pulse prevents an echo from drifting outside of an acquisition window.

7. The method of claim 1 , wherein high resolution images are collected with the single-sided magnetic imaging apparatus without k-space truncation.

8. The method of claim 1 , wherein the magnetic field strength in the field of view is less than 1 Tesla.

9. The method of claim 1 , wherein the inhomogeneity of the magnetic field is between 200 ppm and 200,000 ppm.

10. The magnetic imaging apparatus of claim 2 , wherein the adjacent slices comprise a proximal slice and a distal slice, wherein the proximal slice is positioned closer to the magnetic imaging apparatus than the distal slice, and wherein a target in the distal slice is excited before a target in the proximal slice.

11. The magnetic imaging apparatus of claim 2 , wherein high resolution images are collected with the single-sided magnetic imaging apparatus without k-space truncation.

12. The magnetic imaging apparatus of claim 2 , wherein magnetic field strength in the field of view is less than 1 Tesla.

13. The magnetic imaging apparatus of claim 2 , wherein the inhomogeneity of the magnetic field is between 200 ppm and 200,000 ppm.

14. The magnetic imaging apparatus of claim 2 , wherein the radio frequency coil comprises a radio frequency transmission coil and a radio frequency reception coil.

15. The magnetic imaging apparatus of Claim 10 , wherein the target in the distal slice accumulates the same phase as the target in the proximal slice.

Assignments (3)
INTELLECTUAL PROPERTY SECURITY AGREEMENT Recorded Jul 2, 2026
From: PROMAXO LLC
To: WINDWARD FAMILY OFFICE, LLC
Reel/Frame 075893/0395 →
SECURITY INTEREST Recorded Sep 17, 2025
From: PROMAXO LLC
To: EASTWARD FUND MANAGEMENT, LLC
Reel/Frame 072916/0001 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 6, 2022
From: NACEV, ALEKSANDAR; GOMES, MULLER
To: PROMAXO, INC.
Reel/Frame 060999/0695 →
Continuity (2)
Provisional Application 62987292 · Mar 9, 2020
Related Publication 20230104153A1 · Apr 6, 2023
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