DEVICES, SYSTEMS, AND METHODS FOR TREATING SEPSIS AND/OR VIRAL INFECTION
Methods, devices, and systems for temperature management of a patient having a viral infection or suffering from sepsis are disclosed. Methods, devices, and systems for raising a regional temperature of the patient to and/or actively maintaining a regional temperature of the patient at a target temperature are disclosed. The use of esophageal heat transfer devices to treat patients having a viral infection or suffering from sepsis is disclosed.
1 . A method for treating a patient infected with a virus, the method comprising raising a regional temperature of the patient to and/or actively maintaining a regional temperature of the patient at a target temperature.
2 . The method of claim 1 , wherein the regional temperature is selected from the group consisting of esophageal temperature, thoracic temperature, lung temperature, pulmonary vasculature temperature, and heart temperature.
3 . The method of claim 1 , wherein the target temperature is above the normothermic range.
4 . The method of claim 1 , wherein the target temperature is a range, preferably from about 38° C. to about 42° C.
5 . The method of claim 1 , wherein the target temperature is maintained for a time sufficient to reduce viral load in the patient.
6 . The method of claim 1 , further comprising requesting the results of a test to detect or quantify a virus in a patient sample and/or establishing a diagnosis or clinical impression that the patient suffers from a viral infection.
7 . The method of claim 1 , further comprising placing a heat exchange device into an anatomical structure of the patient.
8 . The method of claim 7 , wherein the anatomical structure is an esophagus and the heat exchange device is an esophageal heat transfer device.
9 . The method of claim 1 , wherein the virus is SARS-CoV-2.
10 . The method of claim 1 , wherein the patient is in respiratory failure, at risk of respiratory failure, and/or mechanically ventilated.
11 . A method for treating a patient suffering from sepsis, the method comprising nasally or orally inserting a distal end of an esophageal heat transfer device into the patient; positioning a heat transfer region of the esophageal heat transfer device in the patient's esophagus, wherein the heat transfer region comprises at least one lumen providing a fluid path for flow of a heat transfer medium; initiating flow of the heat transfer medium along the fluid path; and circulating the heat transfer medium along the fluid path for a time sufficient to raise a regional temperature of the septic patient to and/or actively maintain the regional temperature of the septic patient at a target temperature.
12 . The method of claim 11 , wherein the regional temperature is selected from the group consisting of esophageal temperature, thoracic temperature, lung temperature, pulmonary vasculature temperature, and heart temperature.
13 . The method of claim 11 , wherein the target temperature is above the normothermic range.
14 . The method of claim 11 , wherein the target temperature is a range, preferably from about 38° C. to about 42° C.
15 . The method of claim 11 , wherein the patient is suffering from bacterial sepsis.
16 . The method of claim 11 , wherein the patient is in respiratory failure, at risk of respiratory failure, and/or mechanically ventilated.
17 . A method for treating a patient in respiratory failure, at risk of respiratory failure, and/or mechanically ventilated due to a viral infection and/or sepsis, the method comprising nasally or orally inserting a distal end of an esophageal heat transfer device into the patient; positioning a heat transfer region of the esophageal heat transfer device in the patient's esophagus, wherein the heat transfer region comprises at least one lumen providing a fluid path for flow of a heat transfer medium; initiating flow of the heat transfer medium along the fluid path; and circulating the heat transfer medium along the fluid path for a time sufficient to raise a regional temperature of the patient to and/or actively maintain the regional temperature of the patient at a target temperature, wherein the regional temperature is selected from the group consisting of esophageal temperature, thoracic temperature, lung temperature, pulmonary vasculature temperature, and heart temperature.
18 . The method of claim 17 , wherein the patient is infected with a virus.
19 . The method of claim 18 , wherein the virus is SARS-CoV-2.
20 . The method of claim 17 , wherein the patient is septic.