IP Library › Granted Patent US 12,600,973
Granted Patent B2
US 12,600,973 · App. 17/915,805 · Granted Apr 14, 2026

CpG ODN having immunoregulatory function and use thereof

Inventors: Ligong Wang (Shijiazhuang City, CN); Yan Shao (Shijiazhuang City, CN)
Assignee: Parr Biotechnology (Hebei) Co., Ltd.
C12N15/117A61K39/001156A61K39/001192A61K39/205A61K39/215A61K39/39A61P31/14A61K2039/55505A61K2039/55561C12N2310/17C12N2310/315
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Quick Facts
Patent No.
US 12,600,973
App. No.
17/915,805
Granted
Apr 14, 2026
Kind
B2
Abstract

Provided are an immunomodulatory CpG ODN chemically modified by means of a structure as shown by general formula I and the use thereof. The CpG ODN has an immunostimulatory activity, can stimulate the proliferation of B cells, and produce specific cytokines. The above-mentioned CpG ODN can be used as a vaccine adjuvant alone or in combination with other adjuvants to exert a synergistic effect, and can also be used in the preparation of drugs for preventing or treating tumors, infections, and allergies.

Claims (22)

1 . An immunoregulatory CpG ODN with a maximum length of 26 bp comprising a nucleotide sequence selected from SEQ ID NOs: 1-4 and 6, wherein at least one nucleotide in the nucleotide sequence is a phosphorothioated nucleotide.

2 . The immunoregulatory CpG ODN of claim 1 , wherein the immunoregulatory CpG ODN consists of a nucleotide sequence selected from the group consisting of SEQ ID NOs: 1-4 and 6, and wherein the nucleotide sequence is a completely-phosphorothioated nucleotide sequence.

3 . A method of preventing or treating tumors, microbial infections or allergies in a subject, wherein the method comprises administering an effective amount of the immunoregulatory CpG ODN of claim 1 to the subject.

4 . The method of claim 3 , wherein the subject is a human or an animal, wherein the animal is a mouse, a rat, a domestic animal, or a domestic bird.

5 . A pharmaceutical composition comprising the immunoregulatory CpG ODN of claim 1 and a pharmaceutically acceptable carrier.

6 . A method of preventing or treating tumors, microbial infections or allergies in a subject, wherein the method comprises administering an effective amount of the pharmaceutical composition of claim 5 to the subject.

7 . A vaccine adjuvant comprising the immunoregulatory CpG ODN of claim 1 .

8 . The vaccine adjuvant of claim 7 , further comprising one or more other adjuvants selected from the group consisting of insoluble aluminum salt colloids, oil-water emulsions, microorganisms and their metabolites, nucleic acids and the analogs thereof, cytokines, immunostimulatory complexes, propolis, or liposomes.

9 . A vaccine comprising the immunoregulatory CpG ODN of claim 1 and an antigen, wherein the antigen is a rabies antigen or a SARS-COV-2 antigen.

10 . The vaccine of claim 9 , wherein the vaccine is a rabies vaccine for a human or an animal, and the immunoregulatory CpG ODN consists of a nucleotide sequence as set forth in SEQ ID NO: 3, wherein the nucleotide sequence is a completely-phosphorothioated nucleotide sequence, and the concentration of the CpG ODN is 0.01 μg/ml-1000 μg/ml.

11 . The vaccine of claim 9 , wherein the vaccine is a SARS-COV-2 vaccine, and wherein the vaccine further comprises an aluminum adjuvant.

12 . The vaccine of claim 11 , wherein the immunoregulatory CpG ODN consists of a nucleotide sequence as set forth in SEQ ID NO: 6, and wherein the nucleotide sequence is a completely-phosphorothioated nucleotide sequence.

13 . The vaccine of claim 10 , wherein the concentration of the CpG ODN is 1 μg/ml-10 μg/ml.

14 . The vaccine of claim 11 , wherein the aluminum adjuvant is aluminum hydroxide adjuvant.

15 . The vaccine of claim 11 , wherein the vaccine is an inactivated SARS-COV-2 vaccine.

16 . The vaccine of claim 14 , wherein the concentration of the antigen is 1 μg/mL-10 g/mL; the concentration of the aluminum hydroxide adjuvant is 1 μg/mL-1000 μg/mL; and the concentration of the immunoregulatory CpG ODN is 1 μg/mL-1000 μg/mL.

17 . A rabies vaccine comprising the vaccine adjuvant of claim 7 .

18 . The rabies vaccine of claim 17 , wherein the concentration of CpG ODN in the rabies vaccine is 0.01 μg/ml-1000 μg/ml.

19 . The rabies vaccine of claim 17 , wherein the concentration of CpG ODN in the rabies vaccine is 1 μg/ml-10 μg/ml.

20 . A SARS-COV-2 vaccine comprising the vaccine adjuvant of claim 7 .

21 . The SARS-COV-2 vaccine of claim 20 , wherein the SARS-COV-2 vaccine is an inactivated SARS-COV-2 vaccine, and the concentration of CpG ODN in the SARS-COV-2 vaccine is 0.01 μg/ml-1000 μg/ml.

22 . The SARS-COV-2 vaccine of claim 20 , wherein the SARS-COV-2 vaccine is an inactivated SARS-COV-2 vaccine, and the concentration of CpG ODN in the SARS-COV-2 vaccine is 1 μg/ml-10 μg/ml.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 30, 2022
From: WANG, LIGONG; SHAO, YAN
To: PARR BIOTECHNOLOGY (HEBEI) CO., LTD.
Reel/Frame 061276/0902 →
Priority Claims (1)
CN 202010253089.8 · Apr 1, 2020 · national
Continuity (1)
Related Publication 20230159936A1 · May 25, 2023
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