Granted Patent
B2
US 12,497,462 · App. 17/922,067 · Granted Dec 16, 2025
Anti-CD26 proteins and uses thereof
Inventors:
Hing C. Wong (Miramar, FL); Bai Liu (Miramar, FL); Lin Kong (Miramar, FL); Xiaoyun Zhu (Miramar, FL); Catherine Spanoudis (Miramar, FL)
Assignee:
ImmunityBio, Inc.
C07K16/2896A61K35/17A61K38/1774A61K39/001154A61K40/31A61K40/4224A61K39/00A61K40/11A61K40/4244C07K16/40C07K2317/21C07K2317/24C07K2317/622C12N5/10C12N2510/00C12N2800/00
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Abstract
Provided herein are proteins comprising an anti-CD26 antigen-binding domain. Also provided herein are methods of treating an aging-related disease or an inflammatory disease in a subject that include administering to the subject one of these proteins or a cell expressing one of these proteins.
Claims (43)
1 . A protein comprising an anti-CD26 antigen-binding domain, wherein the anti-CD26 antigen-binding domain comprises:
(a) a heavy chain variable domain comprising a CDR1 comprising SEQ ID NO: 1, a CDR2 comprising SEQ ID NO: 2, and a CDR3 comprising SEQ ID NO: 3, and a light chain variable domain comprising a CDR1 comprising SEQ ID NO: 4, a CDR2 comprising SEQ ID NO: 5, and a CDR3 comprising SEQ ID NO: 6;
(b) a heavy chain variable domain comprising a CDR1 comprising SEQ ID NO: 7, a CDR2 comprising SEQ ID NO: 8, and a CDR3 comprising SEQ ID NO: 9, and a light chain variable domain comprising a CDR1 comprising SEQ ID NO: 10, a CDR2 comprising SEQ ID NO: 11, and a CDR3 comprising SEQ ID NO: 12;
(c) a heavy chain variable domain comprising a CDR1 comprising SEQ ID NO: 13, a CDR2 comprising SEQ ID NO: 14, and a CDR3 comprising SEQ ID NO: 15, and a light chain variable domain comprising a CDR1 comprising SEQ ID NO: 16, a CDR2 comprising SEQ ID NO: 17, and a CDR3 comprising SEQ ID NO: 18;
(d) a heavy chain variable domain comprising a CDR1 comprising SEQ ID NO: 19, a CDR2 comprising SEQ ID NO: 20, and a CDR3 comprising SEQ ID NO: 21, and a light chain variable domain comprising a CDR1 comprising SEQ ID NO: 22, a CDR2 comprising SEQ ID NO: 23, and a CDR3 comprising SEQ ID NO: 24;
(e) a heavy chain variable domain comprising a CDR1 comprising SEQ ID NO: 25, a CDR2 comprising SEQ ID NO: 26, and a CDR3 comprising SEQ ID NO: 27, and a light chain variable domain comprising a CDR1 comprising SEQ ID NO: 28, a CDR2 comprising SEQ ID NO: 29, and a CDR3 comprising SEQ ID NO: 30;
(f) a heavy chain variable domain comprising a CDR1 comprising SEQ ID NO: 31, a CDR2 comprising SEQ ID NO: 32, and a CDR3 comprising SEQ ID NO: 33, and a light chain variable domain comprising a CDR1 comprising SEQ ID NO: 34, a CDR2 comprising SEQ ID NO: 35, and a CDR3 comprising SEQ ID NO: 36;
(g) a heavy chain variable domain comprising a CDR1 comprising SEQ ID NO: 37, a CDR2 comprising SEQ ID NO: 38, and a CDR3 comprising SEQ ID NO: 39, and a light chain variable domain comprising a CDR1 comprising SEQ ID NO: 40, a CDR2 comprising SEQ ID NO: 41, and a CDR3 comprising SEQ ID NO: 42;
(h) a heavy chain variable domain comprising a CDR1 comprising SEQ ID NO: 43, a CDR2 comprising SEQ ID NO: 44, and a CDR3 comprising SEQ ID NO: 45, and a light chain variable domain comprising a CDR1 comprising SEQ ID NO: 46, a CDR2 comprising SEQ ID NO: 47, and a CDR3 comprising SEQ ID NO: 48;
(i) a heavy chain variable domain comprising a CDR1 comprising SEQ ID NO: 49, a CDR2 comprising SEQ ID NO: 50, and a CDR3 comprising SEQ ID NO: 51, and a light chain variable domain comprising a CDR1 comprising SEQ ID NO: 52, a CDR2 comprising SEQ ID NO: 53, and a CDR3 comprising SEQ ID NO: 54; or
(j) a heavy chain variable domain comprising a CDR1 comprising SEQ ID NO: 55, a CDR2 comprising SEQ ID NO: 56, and a CDR3 comprising SEQ ID NO: 57, and a light chain variable domain comprising a CDR1 comprising SEQ ID NO: 58, a CDR2 comprising SEQ ID NO: 59, and a CDR3 comprising SEQ ID NO: 60.
2 . The protein of claim 1 , wherein:
the heavy chain variable domain comprises a sequence that is at least 80% identical to SEQ ID NO: 61 and the light chain variable domain comprises a sequence that is at least 80% identical to SEQ ID NO: 62;
the heavy chain variable domain comprises a sequence that is at least 80% identical to SEQ ID NO: 63 and the light chain variable domain comprises a sequence that is at least 80% identical to SEQ ID NO: 64;
the heavy chain variable domain comprises a sequence that is at least 80% identical to SEQ ID NO: 65 and the light chain variable domain comprises a sequence that is at least 80% identical to SEQ ID NO: 66;
the heavy chain variable domain comprises a sequence that is at least 80% identical to SEQ ID NO: 67 and the light chain variable domain comprises a sequence that is at least 80% identical to SEQ ID NO: 68;
the heavy chain variable domain comprises a sequence that is at least 80% identical to SEQ ID NO: 69 and the light chain variable domain comprises a sequence that is at least 80% identical to SEQ ID NO: 70;
the heavy chain variable domain comprises a sequence that is at least 80% identical to SEQ ID NO: 71 and the light chain variable domain comprises a sequence that is at least 80% identical to SEQ ID NO: 72;
the heavy chain variable domain comprises a sequence that is at least 80% identical to SEQ ID NO: 73 and the light chain variable domain comprises a sequence that is at least 80% identical to SEQ ID NO: 74;
the heavy chain variable domain comprises a sequence that is at least 80% identical to SEQ ID NO: 75 and the light chain variable domain comprises a sequence that is at least 80% identical to SEQ ID NO: 76;
the heavy chain variable domain comprises a sequence that is at least 80% identical to SEQ ID NO: 77 and the light chain variable domain comprises a sequence that is at least 80% identical to SEQ ID NO: 78; or
the heavy chain variable domain comprises a sequence that is at least 80% identical to SEQ ID NO: 79 and the light chain variable domain comprises a sequence that is at least 80% identical to SEQ ID NO: 80.
3 . The protein of claim 1 , wherein the protein is a multi-chain protein.
4 . The protein of claim 1 , wherein the protein is a single-chain protein.
5 . The protein of claim 1 , wherein the protein is an antibody or an antigen-binding antibody fragment.
6 . The protein of claim 1 , wherein the protein is a chimeric antigen receptor (CAR).
7 . A pharmaceutical composition comprising a protein of claim 1 and a pharmaceutically acceptable carrier.
8 . A kit comprising the pharmaceutical composition of claim 7 .
9 . A nucleic acid encoding a protein of claim 1 .
10 . A vector comprising the nucleic acid of claim 9 .
11 . A cell comprising the nucleic acid of claim 9 .
12 . The cell of claim 11 , wherein the cell is an immune cell.
13 . The cell of claim 12 , wherein the immune cell is a T cell, a B cell, or a natural killer (NK) cell.
14 . A pharmaceutical composition comprising a cell of claim 11 and a pharmaceutically acceptable carrier.
15 . A method of treating an age-related disease or an inflammatory disease in a subject, the method comprising administering to the subject a therapeutically effective amount of the protein of claim 1 .
16 . A method of treating an age-related disease or an inflammatory disease in a subject, the method comprising administering to the subject a therapeutically effective amount of the nucleic acid of claim 9 .
17 . A method of treating an age-related disease or an inflammatory disease in a subject, the method comprising administering to the subject a therapeutically effective amount of the cell of claim 11 .
18 . The method of claim 15 , wherein the subject is further administered:
(i) a therapeutically effective amount of an NK cell activating agent and/or an NK cell and/or a monoclonal antibody; and/or
(ii) a therapeutically effective amount of a Treg cell activating agent and/or a Treg cell and/or a monoclonal antibody and/or an advanced glycation end product (AGE) inhibitor.
19 . The method of claim 18 , wherein the method comprises administering a therapeutically effective amount of an NK cell to the subject.
20 . A method of treating cancer in a subject, the method comprising administering to the subject a therapeutically effective amount of the protein of claim 1 .
21 . A method of treating an infectious disease in a subject, the method comprising administering to the subject a therapeutically effective amount of the protein of claim 1 .
Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jul 17, 2024
From: HCW BIOLOGICS INC.
To: IMMUNITYBIO, INC.
Reel/Frame 068014/0474 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jun 2, 2023
From: WONG, HING C.; LIU, BAI; KONG, LIN; ZHU, XIAOYUN; SPANOUDIS, CATHERINE
To: HCW BIOLOGICS, INC.
Reel/Frame 063839/0233 →
Continuity (2)
Provisional Application
63017467
· Apr 29, 2020
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