IP Library Granted Patent US 11,885,858
Granted Patent B2
US 11,885,858 · App. 17/938,229 · Granted Jan 30, 2024

Systems and methods for volumetric acquisition in a single-sided MRI scanner

Inventor: Muller Francis De Matos Gomes (Hayward, CA)
Assignee: Promaxo, Inc.
G01R33/3808G01R33/3415G01R33/381G01R33/383G01R33/385G01R33/4616G01R33/4835A61B5/4381
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Quick Facts
Patent No.
US 11,885,858
App. No.
17/938,229
Granted
Jan 30, 2024
Kind
B2
Abstract

A method for performing magnetic resonance imaging is provided. The method includes providing a magnetic resonance imaging system comprising: a radio frequency receive system comprising a radio frequency receive coil, and a housing, wherein the housing comprises a permanent magnet for providing an inhomogeneous permanent gradient field, a radio frequency transmit system, and a single-sided gradient coil set. The method also includes placing the receive coil proximate a target subject; applying a sequence of chirped pulses via the transmit system; applying a multi-slice excitation along the inhomogeneous permanent gradient field; applying a plurality of gradient pulses via the gradient coil set orthogonal to the inhomogeneous permanent gradient field; acquiring a signal of the target subject via the receive system, wherein the signal comprises at least two chirped pulses; and forming a magnetic resonance image of the target subject.

Claims (47)

1. A magnetic resonance imaging system configured to provide a permanent gradient magnetic field defining an axis, the magnetic resonance imaging system comprising:

a receive coil positionable adjacent to a target subject;

a control circuit configured to:

apply a sequence of chirped pulses having a wide bandwidth;

select a slice selection gradient having the same wide bandwidth;

apply a multi-slice excitation technique along the axis;

apply a plurality of gradient pulses orthogonal to the axis;

acquire a signal of the target subject, wherein application of the sequence of chirped pulses, multi-slice excitation technique, and gradient pulses are timed to refocus a magnetization of the permanent gradient magnetic field at a time of acquisition of the signal within a region of interest encompassing the target subject; and

form a magnetic resonance image of the target subject; and

a single-sided gradient coil set that is non-planar and oriented to partially surround the region of interest, wherein the single-sided gradient coil set is configured to project the plurality of gradient pulses into the region of interest.

2. The magnetic resonance imaging system of claim 1 , wherein the receive coil comprises a flexible coil configured to be affixed to an anatomical portion of a patient for imaging within the region of interest.

3. The magnetic resonance imaging system of claim 1 , further comprising a tuning box and a radio frequency transmit coil, wherein the tuning box is configured to alter the frequency response of the radio frequency transmit coil.

4. The magnetic resonance imaging system of claim 3 , wherein the radio frequency transmit coil is non-planar and oriented to partially surround the region of interest.

5. The magnetic resonance imaging system of claim 1 , wherein the sequence of chirped pulses comprises identical bandwidths and differing durations.

6. The magnetic resonance imaging system of claim 1 , wherein the sequence of chirped pulses configured to produce a one-dimensional signal along the axis of the permanent gradient magnetic field.

7. The magnetic resonance imaging system of claim 6 , wherein the one-dimensional signal comprises a first one-dimensional signal, and wherein the gradient pulses are further configured to produce a second one-dimensional signal and a third one-dimensional signal that are orthogonal to each other and to the axis of the permanent gradient magnetic field.

8. The magnetic resonance imaging system of claim 1 , wherein the gradient pulses are configured for encoding spatial information to the signal.

9. The magnetic resonance imaging system of claim 1 , wherein the combination of the permanent gradient field and the sequence of chirped pulses is configured for slice selection in the inhomogeneous permanent gradient and a frequency encoding gradient.

10. The magnetic resonance imaging system of claim 1 , wherein the sequence of chirped pulses is configured to induce a signal in the target subject, and wherein the receive coil is configured to receive the signal.

11. The magnetic resonance imaging system of claim 1 , further comprising:

a signal conditioning box; and

a radio frequency transmit system, wherein the radio frequency transmit system comprises a radio frequency amplifier and a transmit coil, and wherein the signal conditioning box is configured to enable and disable the radio frequency amplifier.

12. A magnetic resonance imaging system, comprising:

a radio frequency receive system comprising a radio frequency receive coil positionable adjacent to a target subject;

a permanent magnet configured to provide an inhomogeneous permanent gradient field;

a radio frequency transmit system;

a single-sided gradient coil set; and

a control circuit communicably coupled to the radio frequency receive system, the radio frequency transmit system, and the single-sided gradient coil set, wherein the control circuit is configured to:

apply, by the radio frequency transmit system, a sequence of chirped pulses;

apply a multi-slice excitation pulse along the inhomogeneous permanent gradient field;

apply, by the single-sided gradient coil set, a plurality of gradient pulses orthogonal to the inhomogeneous permanent gradient field;

acquire, by the radio frequency receive system, a signal of the target subject; and

form a magnetic resonance image of the target subject.

13. The magnetic resonance imaging system of claim 12 , further comprising a power source, wherein the power source is configured to flow current through at least one of the radio frequency transmit system and the single-sided gradient coil set to generate an electromagnetic field in a region of interest, and wherein the region of interest is configured to receive the target subject.

14. The magnetic resonance imaging system of claim 12 , wherein the multi-slice excitation pulse comprises exciting multiple slices along an axis of the inhomogeneous permanent gradient field.

15. A magnetic resonance imaging system, comprising:

a radio frequency receive coil configured to be placed adjacent to a target subject positioned in a region of interest;

a permanent magnet configured to provide an inhomogeneous permanent gradient field in the region of interest;

a single-sided gradient coil set that is non-planar and oriented to partially surround the region of interest, wherein the single-sided gradient coil set is configured to project a magnetic field gradient into the region of interest;

a radio frequency transmit system; and

a control circuit communicably coupled to the radio frequency receive system and the radio frequency transmit system, wherein the control circuit is configured to:

apply a sequence of chirped pulses having a wide bandwidth;

apply a multi-slice excitation along the inhomogeneous permanent gradient field, wherein the multi-slice excitation comprises exciting multiple slices along an axis of the permanent gradient field in the region of interest, and wherein each of the multiple slices comprises the wide bandwidth;

apply a phase encoding field along axes perpendicular to the axis of the inhomogeneous permanent gradient field; and

acquire a magnetic resonance image of the target subject.

16. The magnetic resonance imaging system of claim 15 , wherein application of the sequence of chirped pulses, multi-slice excitation, and gradient pulses are timed to refocus a magnetization of the inhomogeneous permanent gradient magnetic field at a time of acquisition of a signal.

17. The magnetic resonance imaging system of claim 15 , wherein the radio frequency receive coil is configured to abut an anatomical portion of a patient.

Assignments (3)
INTELLECTUAL PROPERTY SECURITY AGREEMENT Recorded Jul 2, 2026
From: PROMAXO LLC
To: WINDWARD FAMILY OFFICE, LLC
Reel/Frame 075893/0395 →
SECURITY INTEREST Recorded Sep 17, 2025
From: PROMAXO LLC
To: EASTWARD FUND MANAGEMENT, LLC
Reel/Frame 072916/0001 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 16, 2023
From: DE MATOS GOMES, MULLER FRANCIS
To: PROMAXO, INC.
Reel/Frame 065587/0083 →
Continuity (3)
Continuation 17438898
Provisional Application 62823511 · Mar 25, 2019
Related Publication 20230109705A1 · Apr 13, 2023