Adjustable sensing in a his-bundle pacemaker

1. A system for pacing a heart of a patient, comprising:

an electrostimulation circuit configured to provide electrostimulation energy to an interventricular septum between left and right ventricles of the heart;

a cardiac event detector configured to:

receive physiological information of the patient including an atrial activity and a physiologic signal sensed at or near a His-bundle region;

determine a sensing window following the atrial activity, the sensing window shorter than a programmed atrial-to-ventricular delay (AVD) and longer than a patient-specific intrinsic atrial-to-His bundle interval (AHI); and

determine a presence or an absence of a conduction system activity at or near a His-bundle region using the sensed physiologic signal in the sensing window; and

a control circuit configured to generate a control signal to the electrostimulation circuit to initiate electrostimulation of the interventricular septum in response to the absence of the conduction system activity in the sensing window, and to withhold the electrostimulation of the interventricular septum in response to the presence of the conduction system activity in the sensing window.

2. The system of claim 1 , wherein, in response to the absence of the conduction system activity in the sensing window, the control circuit is configured to generate the control signal to the electrostimulation circuit to initiate the electrostimulation of the interventricular septum to activate at least one of a left bundle branch, a right bundle branch, fascicles, or Purkinje fibers.

3. The system of claim 1 , wherein the electrostimulation circuit is electrically coupled to a lead comprising at least one electrode positioned at the interventricular septum to deliver the electrostimulation energy thereto.

4. The system of claim 1 , comprising a leadless electrostimulator device configured to be positioned at the interventricular septum to deliver the electrostimulation energy thereto, the leadless electrostimulator device comprising the electrostimulation circuit and at least one electrode electrically coupled to the electrostimulation circuit.

5. The system of claim 1 , wherein to determine the presence or the absence of the conduction system activity, the cardiac event detector is configured to:

determine a presence or an absence of cardiac arrhythmia in the patient using the received physiological information;

determine a detection mode with a corresponding sensitivity level based on the presence or the absence of the cardiac arrhythmia; and

detect the conduction system activity from the physiologic signal sensed from the His-bundle region using the determined detection mode.

6. The system of claim 5 , wherein to determine the detection mode, the cardiac event detector is configured to:

determine a first detection mode corresponding to a first sensitivity level in response to the presence of the cardiac arrhythmia; and

determine a second detection mode corresponding to a second sensitivity level in response to the absence of the cardiac arrhythmia,

wherein the first sensitivity level is higher than the second sensitivity level.

7. The system of claim 6 , wherein the first detection mode includes a first sensing threshold, the second detection mode include a second sensing threshold higher than the first sensing threshold.

8. The system of claim 5 , wherein the cardiac arrhythmia includes an atrial tachyarrhythmia event or a ventricular tachyarrhythmia event.

9. The system of claim 1 , wherein the cardiac event detector is configured to determine the presence or the absence of the conduction system activity using a comparison of the sensed physiologic signal in the sensing window to an adjustable threshold.

10. The system of claim 1 , wherein, in response to the presence of the conduction system activity:

the cardiac event detector is configured to determine the conduction system activity as an inhibitory event including at least one of a conducted His-bundle response, a far-field conducted R-wave, or a premature ventricular contraction; and

the control circuit is configured to generate the control signal to the electrostimulation circuit to withhold the electrostimulation of the interventricular septum in response to the conduction system activity being determined as the inhibitory event.

11. The system of claim 10 , wherein the cardiac event detector is configured to determine the conduction system activity as the inhibitory event using a timing of the conduction system activity or a morphology of the conduction system activity.

12. The system of claim 10 , wherein, in response to the presence of the conduction system activity:

the cardiac event detector is configured to determine the conduction system activity as a far-field P-wave (FFPW); and

the control circuit is configured to generate the control signal to the electrostimulation circuit to initiate the electrostimulation of the interventricular septum in response to the conduction system activity being determined as the FFPW.

13. A system for pacing a heart, comprising:

an electrostimulation circuit configured to provide electrostimulation energy to an interventricular septum between left and right ventricles of the heart;

a cardiac event detector configured to:

receive physiological information of a patient including cardiac information and a His-bundle signal different than the cardiac information;

determine a presence or an absence of cardiac arrhythmia using the cardiac information; and

detect a conduction system activity from the His-bundle signal, including to detect the conduction system activity from the His-bundle signal using a first detection mode corresponding to a first sensitivity in response to the presence of the cardiac arrhythmia, and to detect the conduction system activity from the His-bundle signal using a second detection mode corresponding to a second sensitivity in response to the absence of the cardiac arrhythmia, the first sensitivity being higher than the second sensitivity; and

a control circuit configured to generate a control signal to the electrostimulation circuit to initiate electrostimulation of the interventricular septum based on the detected conduction system activity.

14. The system of claim 13 , wherein the electrostimulation circuit is configured to, in response to the control signal, provide the electrostimulation energy to the interventricular septum to activate at least one of a left bundle branch, a right bundle branch, fascicles, or Purkinje fibers.

15. The system of claim 13 , wherein the control circuit is configured to generate the control signal to the electrostimulation circuit to initiate the electrostimulation of the interventricular septum if the conduction system activity is detected from the His-bundle signal, and to withhold the electrostimulation of the interventricular septum if the conduction system activity is not detected from the His-bundle signal.

16. A method for pacing a heart of patient, comprising:

receiving physiological information of the patient including an atrial activity and a physiologic signal sensed from a His-bundle region;

determining a sensing window following the atrial activity, the sensing window shorter than a programmed atrial-to-ventricular delay (AVD) and longer than a patient-specific intrinsic atrial-to-His bundle interval (AHI);

determining a presence or an absence of a conduction system activity using the sensed physiologic signal in the sensing window; and

adjusting delivery of electrostimulation energy to an interventricular septum between left and right ventricles of the heart based on the determined presence or the determined absence of the conduction system activity in the sensing window, including:

initiating electrostimulation of the interventricular septum in response to the absence of the conduction system activity in the sensing window; and

withholding the electrostimulation of the interventricular septum in response to the presence of the conduction system activity in the sensing window.

17. The method of claim 16 , wherein, in response to the absence of the conduction system activity in the sensing window, initiating the electrostimulation of the interventricular septum includes activating at least one of a left bundle branch, a right bundle branch, fascicles, or Purkinje fibers.

18. The method of claim 16 , wherein determining the presence or the absence of the conduction system activity includes:

determining a presence or an absence of cardiac arrhythmia in the patient using the received physiological information;

determining a detection mode with a corresponding sensitivity level based on the presence or the absence of the cardiac arrhythmia; and

detecting the conduction system activity from the physiologic signal sensed from the His-bundle region using the determined detection mode.

19. The method of claim 18 , wherein determining the detection mode includes determining a first detection mode corresponding to a first sensitivity level in response to the presence of the cardiac arrhythmia, and a second detection mode corresponding to a second sensitivity level in response to the absence of the cardiac arrhythmia, the first sensitivity level being higher than the second sensitivity level.

20. The method of claim 16 , comprising, in response to the presence of the conduction system activity:

classifying the conduction system activity as an inhibitory event or a far-field P-wave (FFPW), the inhibitory event including at least one of a conducted His-bundle response, a far-field conducted R-wave, or a premature ventricular contraction;

wherein adjusting the delivery of electrostimulation energy to the interventricular septum further incudes withholding the electrostimulation of the interventricular septum in response to the conduction system activity being classified as the inhibitory event, and initiating the electrostimulation of the interventricular septum in response to the conduction system activity being classified as the FFPW.