PHARMACEUTICAL COMPOSITIONS COMPRISING PERILLYL ALCOHOL DERIVATIVES
A pharmaceutical composition is provided which includes perillyl alcohol conjugated with a therapeutic agent and further includes and a hydrolyzable acylated aliphatic tail. A method of using the pharmaceutical composition is also provided for treating a condition or disease of a patient, e.g., cancer.
1 . A method for treating a disease or disorder in a mammal, comprising the step of administering to the mammal a pharmaceutical composition comprising a therapeutically effective amount of a topiramate perillyl alcohol (POH) linoleate triple conjugate compound having a structural formula of
or a pharmaceutically acceptable salt thereof.
2 . The method of claim 1 , wherein the pharmaceutical composition is administered by inhalation, intranasally, orally, intravenously, topically, transdermally, subcutaneously or intramuscularly.
3 . The method of claim 1 , wherein a symptom of the disease or disorder is seizures.
4 . The method of claim 1 , wherein the mammal is a human.
5 . A method for treating a disease or disorder in a mammal, comprising the step of administering to the mammal a pharmaceutical composition comprising a therapeutically effective amount of a lamotrigine perillyl alcohol (POH) linoleate triple conjugate compound having a structural formula of
or a pharmaceutically acceptable salt thereof.
6 . The method of claim 1 , wherein the pharmaceutical composition is administered by inhalation, intranasally, orally, intravenously, topically, transdermally, subcutaneously or intramuscularly.
7 . The method of claim 1 , wherein a symptom of the disease or disorder is seizures.
8 . The method of claim 1 , wherein the mammal is a human.