Granted Patent B2

US 12,616,846 · App. 17/943,780 · Granted May 5, 2026

Inventors: Satoru Suehara (Kanagawa, JP); Mayu Hata (Yokohama, JP)

Assignee: TERUMO KABUSHIKI KAISHA

A61N5/0601A61N2005/0611A61N2005/063

Abstract

Claims (54)

1 . A treatment apparatus configured to irradiate an antibody-photosensitive substance bound to a tumor cell with excitation light, the treatment apparatus comprising:

a main shaft including a distal end portion and a proximal end portion;

an inflation portion disposed distal of the main shaft and configured to be inflated by inflowing a fluid, a proximal end portion of the inflation portion is fixed to the distal end portion of the main shaft;

an irradiation shaft accommodated in the main shaft, the irradiation shaft protruding from the distal end portion of the main shaft, passing through an inside of the inflation portion and extending beyond a distal end of the inflation portion so as to form a distal shaft that is a portion of the irradiation shaft protruding from the distal end of the inflation portion;

at least one irradiation unit including a light-emitting unit at a distal portion of the irradiation unit, the light-emitting unit configured to emit outward the excitation light of the antibody-photosensitive substance;

wherein the irradiation shaft includes an irradiation lumen that is closed at a most distal end of the irradiation shafter and opened at a most proximal end of the irradiation shaft, the irradiation lumen passing through the inside of the inflation portion to an inside of the distal shaft and configured to movably accommodate the irradiation unit;

an insertion port for receiving the irradiation unit into the irradiation lumen is disposed on a proximal side of the irradiation shaft;

the distal shaft includes the most distal end of the irradiation shaft, which closes a distal end of the irradiation lumen and protrudes distally relative to the distal end of the inflation portion by a predetermined protrusion length in a range of 10 mm to 50 mm;

wherein an outer diameter of the distal shaft is smaller than a maximum outer diameter of the inflation portion when being inflated the inflation portion; and

wherein the light-emitting unit of the irradiation unit is configured to be disposed in a first portion of the irradiation lumen disposed on the inside of the inflation portion and a second portion of the irradiation lumen disposed on the inside of the distal shaft, so as to emit the excitation light of the antibody-photosensitive substance from the inflation portion and the distal shaft.

2 . The treatment apparatus according to claim 1 , wherein

the distal shaft is configured to emit the excitation light in a direction substantially perpendicular to an axial center of the distal shaft; and

the inflation portion is configured to emit the excitation light in a substantially distal direction.

3 . The treatment apparatus according to claim 1 , wherein

the inflation portion has an abutment surface facing the distal side of the inflation portion in an inflated state of the inflation portion; and

the abutment surface has a portion that is separated from an axial center of the distal shaft and that partially protrudes toward the distal side.

4 . The treatment apparatus according to claim 1 , further comprising:

an annular reinforcement portion disposed on a distal side of the inflation portion and surrounding a proximal portion of the distal shaft.

5 . The treatment apparatus according to claim 1 , wherein the inflation portion is configured to move relative to the main shaft in an axial center direction of the main shaft.

6 . The treatment apparatus according to claim 1 , wherein the light-emitting unit of the irradiation unit is configured to move from the first portion of the irradiation lumen to the second portion of the irradiation lumen.

7 . The treatment apparatus according to claim 1 , wherein the distal shaft includes a bent portion such that an axial center of a distal portion of the distal shaft is bent at an angle of less than 90° with respect to an axial center of a proximal portion of the distal shaft.

8 . A treatment method, comprising:

intravenously administering an antibody-photosensitive substance;

inserting a treatment apparatus into a living body after 12 hours to 36 hours from the intravenous administration of the antibody-photosensitive substance, the treatment apparatus including a main shaft including a distal end portion and a proximal end portion, an inflation portion disposed distal of the main shaft and configured to be inflated by inflowing a fluid, a proximal end portion of the inflation portion is fixed to the distal end portion of the main shaft, an irradiation shaft accommodated in the main shaft, the irradiation shaft protruding from the distal end portion of the main shaft, passing through an inside of the inflation portion and extending beyond a distal end of the inflation portion so as to form a distal shaft that is a portion of the irradiation shaft protruding from the distal end of the inflation portion, and at least one irradiation unit including a light-emitting unit at a distal portion of the irradiation unit, the light-emitting unit configured to emit outward the excitation light of the antibody-photosensitive substance, and wherein the irradiation shaft includes an irradiation lumen that is closed at a most distal end of the irradiation shaft and opened at a most proximal end of the irradiation shaft, the irradiation lumen passing through the inside of the inflation portion to an inside of the distal shaft and configured to movably accommodate the irradiation unit, an insertion port for receiving the irradiation unit into the irradiation lumen is disposed on a proximal side of the irradiation shaft, the distal shaft includes the most distal end of the irradiation shaft, which closes a distal end of the irradiation lumen and protrudes distally relative to the distal end of the inflation portion by a predetermined protrusion length in a range of 10 mm to 50 mm, wherein an outer diameter of the distal shaft is smaller than a maximum outer diameter of the inflation portion when being inflated the inflation portion, wherein the light-emitting unit of the irradiation unit is configured to be disposed in a first portion of the irradiation lumen disposed on the inside of the inflation portion and a second portion of the irradiation lumen disposed on the inside of the distal shaft, so as to emit the excitation light of the antibody-photosensitive substance from the inflation portion and the distal shaft;

inserting the distal shaft into a body lumen;

inflating the inflation portion in the living body;

emitting the excitation light from the distal shaft to a surrounding tissue;

emitting the excitation light from the inflation portion to the surrounding tissue; and

deflating the inflation portion.

9 . The treatment method according to claim 8 , further comprising:

simultaneously performing the emitting of the excitation light from the distal shaft and the emitting of the excitation light from the inflation portion.

10 . The treatment method according to claim 8 , wherein the body lumen is a cervical canal, and wherein in the inserting of the distal shaft into the cervical canal, the method further comprises:

abutting an abutment surface against a uterine vagina, the abutment surface being disposed on a proximal side of the distal shaft, the distal shaft extending from the abutment surface and the abutment surface facing a distal side of the distal shaft.

11 . The treatment method according to claim 8 , further comprising:

detecting fluorescence emitted by the antibody-photosensitive substance and checking an intensity of the fluorescence.

12 . The treatment method according to claim 8 , wherein the living body is a vagina of a patient, and the body lumen is a cervical canal of the patient.

13 . The treatment method according to claim 8 , further comprising:

treating the surrounding tissue for cervical cancer.

14 . The treatment method according to claim 8 , further comprising:

moving the light-emitting unit of the irradiation unit from the first portion of the irradiation lumen to the second portion of the irradiation lumen.

15 . The treatment method according to claim 8 , wherein the distal shaft includes a bent portion such that an axial center of a distal portion of the distal shaft is bent at an angle of less than 90° with respect to an axial center of a proximal portion of the distal shaft.

16 . A treatment method comprising:

intravenously administering an antibody-photosensitive substance;

inserting a treatment apparatus into a living body after the intravenous administration of the antibody-photosensitive substance, the treatment apparatus including a main shaft including a distal end portion and a proximal end portion, an inflation portion disposed distal of the main shaft and configured to be inflated by inflowing a fluid, a proximal end portion of the inflation portion is fixed to the distal end portion of the main shaft, an irradiation shaft accommodated in the main shaft, the irradiation shaft protruding from the distal end portion of the main shaft, passing through an inside of the inflation portion and extending beyond a distal end of the inflation portion so as to form a distal shaft that is a portion of the irradiation shaft protruding from the distal end of the inflation portion, and at least one irradiation unit including a light-emitting unit at a distal portion of the irradiation unit, the light-emitting unit configured to emit outward the excitation light of the antibody-photosensitive substance, and wherein the irradiation shaft includes an irradiation lumen that is closed at a most distal end of the irradiation shaft and opened at a most proximal end of the irradiation shaft, the irradiation lumen passing through the inside of the inflation portion to an inside of the distal shaft and configured to movably accommodate the irradiation unit, an insertion port for receiving the irradiation unit into the irradiation lumen is disposed on a proximal side of the irradiation shaft, the distal shaft includes the most distal end of the irradiation shaft, which closes a distal end of the irradiation lumen and protrudes distally relative to the distal end of the inflation portion by a predetermined protrusion length in a range of 10 mm to 50 mm, wherein an outer diameter of the distal shaft is smaller than a maximum outer diameter of the inflation portion when being inflated the inflation portion, wherein the light-emitting unit of the irradiation unit is configured to be disposed in a first portion of the irradiation lumen disposed on the inside of the inflation portion and a second portion of the irradiation lumen disposed on the inside of the distal shaft, so as to emit the excitation light of the antibody-photosensitive substance from the inflation portion and the distal shaft;

inserting the distal shaft into a body lumen;

inflating the inflation portion in the living body; and

emitting the excitation light from the distal shaft and the inflation portion to surrounding tissue.

17 . The treatment method according to claim 16 , further comprising:

simultaneously performing the emitting of the excitation light from the distal shaft and the emitting of the excitation light from the inflation portion.

18 . The treatment method according to claim 16 , further comprising:

detecting fluorescence emitted by the antibody-photosensitive substance and checking an intensity of the fluorescence.

19 . The treatment method according to claim 16 , further comprising:

moving the light-emitting unit of the irradiation unit from the first portion of the irradiation lumen to the second portion of the irradiation lumen.

20 . The treatment method according to claim 16 , wherein the distal shaft includes a bent portion such that an axial center of a distal portion of the distal shaft is bent at an angle of less than 90° with respect to an axial center of a proximal portion of the distal shaft.

Assignments (1)

Priority Claims (1)

Continuity (2)

References Cited (21)