SSTR4 agonist salts
The present invention relates to specific salts of (1S,5R)-(1α,5α,6α)-N-[1,1-dimethyl-2-[(3-methyl-2-pyridyl)oxy]ethyl]-3-azabicyclo[3.1.0]hexane-6-carboxamide, to pharmaceutical compositions comprising said salts, to methods of using said salts to treat physiological disorders, and to intermediates useful in the synthesis of the salts.
1. A compound of the formula:
wherein the compound is crystalline and is characterized by an X-ray powder diffraction pattern using CuKα radiation comprising peaks at diffraction angle 2-theta 10.6°±0.2° 15.2°±0.2° and 21.9°±0.2°.
2. A compound of the formula:
wherein the compound is crystalline and is characterized by an X-ray powder diffraction pattern using CuKα radiation comprising peaks at diffraction angle 2-theta 5.4°±0.2°, 10.3°±0.2°, 16.2°±0.2°, and 20.8°±0.2°.
3. A compound of formula:
wherein the compound is crystalline and is characterized by an X-ray powder diffraction pattern using CuKα radiation comprising peaks at diffraction angle 2-theta 4.9°±0.2°, 17.3°±0.2°, and 18.1°±0.2°.
4. A pharmaceutical composition comprising the compound of claim 1 and one or more pharmaceutically acceptable carriers, diluents, or excipients.
5. A method of treating pain in a patient comprising administering to said patient in need of such treatment an effective amount of the compound of claim 1 .
6. A method of treating chronic back pain in a patient comprising administering to said patient in need of such treatment an effective amount of the compound of claim 1 .
7. A method of treating neuropathic pain in a patient comprising administering to said patient in need of such treatment an effective amount of the compound of claim 1 .
8. The method of claim 7 , wherein the neuropathic pain is diabetic peripheral neuropathic pain.
9. A method of treating pain associated with osteoarthritis in a patient comprising administering to said patient in need of such treatment an effective amount of the compound of claim 1 .
10. A method of treating pain in a patient comprising administering to said patient in need of such treatment an effective amount of the compound of claim 2 .
11. A method of treating chronic back pain in a patient comprising administering to said patient in need of such treatment an effective amount of the compound of claim 2 .
12. A method of treating neuropathic pain in a patient comprising administering to said patient in need of such treatment an effective amount of the compound of claim 2 .
13. The method of claim 12 , wherein the neuropathic pain is diabetic peripheral neuropathic pain.
14. A method of treating pain associated with osteoarthritis in a patient comprising administering to said patient in need of such treatment an effective amount of the compound of claim 2 .
15. A method of treating pain in a patient comprising administering to said patient in need of such treatment an effective amount of the compound of claim 3 .
16. A method of treating chronic back pain in a patient comprising administering to said patient in need of such treatment an effective amount of the compound of claim 3 .
17. A method of treating neuropathic pain in a patient comprising administering to said patient in need of such treatment an effective amount of the compound of claim 3 .
18. The method of claim 17 , wherein the neuropathic pain is diabetic peripheral neuropathic pain.
19. A method of treating pain associated with osteoarthritis in a patient comprising administering to said patient in need of such treatment an effective amount of the compound of claim 3 .