SSTR4 agonist salts
The present invention relates to specific salts of (1S,5R)-(1α,5α,6α)-N-[1,1-dimethyl-2-[(3-methyl-2-pyridyl)oxy]ethyl]-3-azabicyclo[3.1.0]hexane-6-carboxamide, to pharmaceutical compositions comprising said salts, to methods of using said salts to treat physiological disorders, and to intermediates useful in the synthesis of the salts.
1 . A crystalline compound of the formula:
or a hydrate thereof.
2 . The compound of claim 1 , wherein the compound is a hydrate.
3 . The compound of claim 1 , wherein the compound is a hydrate, wherein the water content at ambient temperature is in the range of 3% to 9% by weight.
4 . The compound of claim 1 , wherein the compound is:
5 . The compound of claim 1 , wherein the compound is:
6 . A pharmaceutical composition comprising the compound of claim 1 and one or more pharmaceutically acceptable carriers, diluents, or excipients.
7 . A method of treating pain in a patient comprising administering to said patient in need of such treatment an effective amount of the compound of claim 1 .
8 . A method of treating chronic back pain in a patient comprising administering to said patient in need of such treatment an effective amount of the compound of claim 1 .
9 . A method of treating neuropathic pain in a patient comprising administering to said patient in need of such treatment an effective amount of the compound of claim 1 .
10 . The method of claim 9 , wherein the neuropathic pain is diabetic peripheral neuropathic pain.
11 . A method of treating pain associated with osteoarthritis in a patient comprising administering to said patient in need of such treatment an effective amount of the compound of claim 1 .