COMPOSITIONS AND METHODS FOR TREATING DEPRESSION
Disclosed are a novel combination of specific therapeutics selected from S-adenosyl methionine or a salt thereof, folic acid or a metabolite or salt thereof, and one or more omega-3 fatty acids or salts thereof, useful for a variety of conditions, as discussed herein. Methods of treatment include the treatment of neuropsychiatric conditions, such as depression.
1 - 103 . (canceled)
104 . A method for improving or stabilizing mood of a subject comprising administering to the subject:
S-adenosyl methionine or a salt thereof;
methyl folate or a salt thereof; and
one or more omega-3 fatty acids or salts thereof, wherein the one or more omega-3 fatty acids or salts thereof comprises at least 60% eicosapentaenoic acid (EPA) or a salt thereof.
105 . The method of claim 104 , wherein the S-adenosyl methionine or salt thereof is administered in an amount from 200 mg to 4000 mg, inclusive.
106 . The method of claim 104 , wherein the S-adenosyl methionine or salt thereof is administered in an amount from 800 mg to 1600 mg, inclusive.
107 . The method of claim 104 , wherein the methyl folate or salt thereof is administered in an amount from 1 mg to 45 mg, inclusive.
108 . The method of claim 104 , wherein the methyl folate or salt thereof is administered in an amount from 5 mg to 20 mg, inclusive.
109 . The method of claim 104 , wherein the one or more omega-3 fatty acids or salts thereof is administered in an amount from 500 mg to 5000 mg, inclusive.
110 . The method of claim 104 , wherein the one or more omega-3 fatty acids or salts thereof is administered in an amount from 800 mg to 1600 mg, inclusive.
111 . The method of claim 104 , wherein the one or more omega-3 fatty acids or salts thereof are selected from EPA, docosahexaenoic acid (DHA), and combinations thereof.
112 . The method of claim 104 , wherein:
the S-adenosyl methionine or salt thereof is administered in an amount from 200 mg to 4000 mg, inclusive;
the methyl folate or salt thereof is administered in an amount from 1 mg to 45 mg, inclusive; and
the one or more omega-3 fatty acids or salts thereof is administered in an amount from 500 mg to 5000 mg, inclusive.
113 . The method of claim 104 , wherein:
the S-adenosyl methionine or salt thereof is administered in an amount from 800 mg to 1600 mg, inclusive;
the methyl folate or salt thereof is administered in an amount from 5 mg to 20 mg, inclusive; and
the one or more omega-3 fatty acids or salts thereof is administered in an amount from 800 mg to 1600 mg, inclusive.
114 . The method of claim 104 , wherein the subject is a human.
115 . The method of claim 104 , wherein the subject has Major Depressive Disorder.
116 . The method of claim 104 , wherein the subject does not have Major Depressive Disorder.
117 . The method of claim 104 further comprising administering vitamin B 12 to the subject.
118 . The method of claim 104 further comprising administering vitamin E to the subject.
119 . The method of claim 104 , wherein one or more of the S-adenosyl methionine or salt thereof, methyl folate or salt thereof, and one or more omega-3 fatty acids or salts thereof are present in a composition comprising vitamin E.
120 . A method for improving cognition in a subject comprising administering to the subject:
S-adenosyl methionine or a salt thereof;
methyl folate or a salt thereof; and
one or more omega-3 fatty acids or salts thereof, wherein the one or more omega-3 fatty acids or salts thereof comprises at least 60% eicosapentaenoic acid (EPA) or a salt thereof.
121 . The method of claim 120 , wherein the subject has dementia.
122 . The method of claim 120 , wherein the subject does not have dementia.
123 . A method for promoting happiness and/or reducing depressive symptoms in a subject comprising administering to the subject:
S-adenosyl methionine or a salt thereof;
methyl folate or a salt thereof; and
one or more omega-3 fatty acids or salts thereof, wherein the one or more omega-3 fatty acids or salts thereof comprises at least 60% eicosapentaenoic acid (EPA) or a salt thereof.
124 . The method of claim 123 , wherein the subject does not meet the clinical criteria for Major Depressive Disorder and/or does not meet the clinical criteria for treatment with a prescription anti-depressant.