Compositions comprising at least one n-acetylated and at least one fucosylated oligosaccharide for use in the promotion of digestive capacity in infants and young children
This invention relates to compositions for use in the promotion of the development and/or of the growth of the surface area of the small intestine and in the associated improvement of the digestive capacity in an infant or in a young child.
1. A method of promoting the digestive capacity in a child in need thereof, the method comprising administering to the child a growing-up milk comprising at least one N-acetylated oligosaccharide and at least one fucosylated oligosaccharide, wherein the growing-up milk is administered in an effective amount for improving enterohepatic circulation in the child.
2. The method of claim 1 , for promoting the capacity to digest fat, liposoluble vitamins, proteins and carbohydrates in the child.
3. The method of claim 1 , for promoting the development and/or the growth of the surface area of the small intestine of the child.
4. The method of claim 1 , for promoting the increase of the villi length in the small intestine of the child.
5. The method of claim 1 , wherein the at least one N-acetylated oligosaccharide is selected from the group consisting of lacto-N-neotetraose (LNnT), lacto-N-tetraose (LNT), para-lacto-N-neohexaose (para-LNnH), disialyllacto-N-tetraose (DSLNT) and combinations thereof.
6. The method of claim 1 , wherein the at least one N-acetylated oligosaccharide comprises lacto-N-neotetraose (LNnT).
7. The method of claim 1 , wherein the at least one fucosylated oligosaccharide is selected from the group consisting of 2′-fucosyllactose, 3′fucosyllactose, difucosyllactose, lacto-N-fucopentaose I, lacto-N-fucopentaose II, lacto-N-fucopentaose III, lacto-N-fucopentaose V, lacto-N-fucohexaose, lacto-N-difucohexaose I, fucosyllacto-N-hexaose, fucosyllacto-N-neohexaose I, fucosyllacto-N-neohexaose II, difucosyllacto-N-hexaose I, difucosyllacto-N-neohexaose I, difucosyllacto-N-neohexaose II, fucosyl-para-Lacto-N-hexaose, and combinations thereof.
8. The method of claim 1 , wherein the at least one fucosylated oligosaccharide comprises a 2′ fucosyl-epitope.
9. The method of claim 1 , wherein the at least one fucosylated oligosaccharide comprises 2′-fucosyllactose (2′FL).
10. The method of claim 1 , wherein the growing-up milk comprises 2′-fucosyllactose and lacto-N-neotetraose (LNnT), or comprises an oligosaccharide mixture consisting of 2′-fucosyllactose (2′FL) and lacto-N-neotetraose (LNnT).
11. The method of claim 1 , wherein the at least one N-acetylated oligosaccharide and the at least one fucosylated oligosaccharide are present in a ratio N-acetylated oligosaccharide:fucosylated oligosaccharide of from 1:20 to 2:1.
12. The method of claim 1 , wherein
a. the at least one fucosylated oligosaccharide is in a total amount of 0.005-5 g/L of the growing-up milk and/or in a total amount of 0.004-3.8 g/100 g of the growing-up milk on a dry weight basis; and/or
b. the at least one N-acetylated oligosaccharide is in a total amount of 0.1-2.5 g/L of the growing-up milk and/or in a total amount of 0.08-1.9 g/100 g of the growing-up milk on a dry weight basis.
13. The method of claim 1 , wherein
a. the at least one fucosylated oligosaccharide(s) is in a total amount of 0.02-2 g/L of the growing-up milk and/or in a total amount of 0.015-1.5 g/100 g of the growing-up milk on a dry weight basis; and/or
b. the at least one N-acetylated oligosaccharide(s) is/are in a total amount of 0.5-1 g/L of the growing-up milk and/or in a total amount of 0.4-0.8 g/100 g of the growing-up milk on a dry weight basis.
14. The method of claim 1 , wherein
a. the at least one fucosylated oligosaccharide is in a total amount of 0.1-2.5 g/L of the growing-up milk and/or in a total amount of 0.08-1.9 g/100 g of the growing-up milk on a dry weight basis; and/or
b. the at least one N-acetylated oligosaccharide is in a total amount of 0.5-0.8 g/L of the growing-up milk and/or in a total amount of 0.4-0.6 g/100 g of the growing-up milk on a dry weight basis.
15. The method of claim 1 , wherein the growing-up milk comprises at least another oligosaccharide and/or a fiber and/or a precursor thereof selected from the group consisting of galacto-oligosaccharides (GOS), fructo-oligosaccharides (FOS), xylooligosaccharides (XOS), inulin, polydextrose, sialylated oligosaccharides, sialic acid, fucose and combinations thereof.
16. The method of claim 1 , the growing-up milk further comprises at least one probiotic in an amount of from 10 3 to 10 12 cfu/g of the growing-up milk (dry weight).