Aceclidine derivatives, compositions thereof and methods of use thereof

1. A pharmaceutically acceptable salt of a compound comprising a cation of formula (I),

wherein R 1 is an alkyl, and

wherein R 2 is an amine or tert-butyl.

2. An ophthalmological composition comprising a therapeutically effective amount of (i) a pharmaceutically acceptable salt of a compound comprising a cation of formula (I):

wherein R 1 is an alkyl, and

wherein R 2 is an amine or tert-butyl, or

(ii) a compound of formula (III)

or a pharmaceutically acceptable salt thereof,

wherein the pH of the composition is at least 3 log units less than the pKa of the compound.

3. The composition of claim 2 , further comprising a cyclodextrin.

4. The composition of claim 3 , wherein the cyclodextrin is selected from an alpha-cyclodextrin, a beta-cyclodextrin and a gamma-cyclodextrin.

5. A method of treating presbyopia or glaucoma comprising administering to a patient in need thereof a therapeutically effective amount of (i) a pharmaceutically acceptable salt of a compound comprising a cation of formula (I):

wherein R 1 is an alkyl, and

wherein R 2 is an amine or tert-butyl, or

(ii) a compound of formula (III)

or a pharmaceutically acceptable salt thereof.

6. A method of reducing hyperemia comprising administering to a patient in need thereof a therapeutically effective amount of (i) a pharmaceutically acceptable salt of a compound comprising a cation of formula (I):

wherein R 1 is an alkyl, and

wherein R 2 is an amine or tert-butyl, or

(ii) a compound of formula (III)

or a pharmaceutically acceptable salt thereof.