Analyte detection apparatus and method of detecting an analyte
An analyte detection apparatus includes a radiation source for irradiating a sample and a receiver to receive an optical Raman spectrum of radiation transmitted back from the sample, the spectrum including one or more parts of significance to an analyte to be detected and one or more parts not of significance to an analyte to be detected. The receiver includes different types of analysis device each arranged to receive a selected part of the spectrum. The different types of analysis device include at least one analysis device having high resolution and/or high signal to noise ratio for detecting a part of the spectrum of significance to the analyte to be detected and at least one second type of analysis device which provides lower resolution and/or lower signal-to-noise ratio, for detecting a part of the spectrum not of significance to the analyte to be detected.
1. An analyte detection apparatus, comprising:
a radiation source for irradiating a sample, and
a receiver, to receive an optical Raman spectrum of radiation transmitted back from the sample in response to the received radiation from the radiation source, the optical Raman spectrum including one or more parts of significance to an analyte to be detected and one or more parts not of significance to an analyte to be detected,
wherein the receiver comprises a plurality of different types of analysis device each arranged to receive a selected part of the received Raman optical spectrum transmitted back from the sample
wherein the different types of analysis device include at least one analysis device which has resolution and/or signal to noise ratio for detecting a part of the spectrum of significance to the analyte to be detected and at least one second type of analysis device which provides lower resolution and/or lower signal-to-noise ratio, for detecting a part of the spectrum not of significance to the analyte to be detected.
2. An apparatus according to claim 1 , comprising one or more filtration devices arranged to filter the received optical spectrum and direct designated components to particular ones of the plurality of different types of analysis devices.
3. An apparatus according to claim 1 , wherein the filtration devices include at least one tunable filtration device.
4. An apparatus according to claim 3 , wherein the tunable filtration device comprises one or more of mechanically tuned filtration devices, electrically tuned filtration devices and acousto-optically tuned filtration devices.
5. An apparatus according to claim 1 , wherein the different analysis devices include at least one CCD-based spectrometer.
6. An apparatus according to claim 5 , wherein the different analysis devices include at least one CMOS-based spectrometer.
7. An apparatus according to claim 6 , wherein one or more of Fourier-wave Spectrometry and Stationary Wave Integrated Fourier Transform Spectrometry are used.
8. An apparatus according to claim 1 , wherein one or more of the selected parts of the received Raman optical spectrum is coupled to a dispersion member.
9. An apparatus according to claim 1 , wherein the apparatus is arranged to determine concentration of an analyte.
10. An apparatus according to claim 9 , wherein the analyte is selected from the group including glucose, lactate, fatty acids, urea, carbamide, cholesterol, alcohol and hemoglobin.
11. A method of detecting an analyte, the method comprising:
irradiating a sample with optical radiation from a radiation source;
receiving an optical Raman spectrum of radiation transmitted back by the sample in response to the received radiation from the radiation source, the optical Raman spectrum including one or more parts of significance to an analyte to be detected and one or more parts not of significance to an analyte to be detected, and
selectively coupling different parts of the received Raman spectrum to different analysis devices wherein the different analysis devices include at least one analysis device which has resolution and/or signal to noise ratio for detecting a part the spectrum of significance to the analyte to be detected and at least one second type of analysis device which provides lower resolution and lower signal-to-noise ratio, for detecting a part of the spectrum not of significance to the analyte to be detected.
12. A method according to claim 11 , further comprising filtering the received spectrum into two or more components and coupling a first of the components to a first analysis device and a second of the components to a second analysis device.
13. A method according to claim 12 , wherein the first analysis device is a CCD-based spectrometer.
14. A method according to claim 13 , wherein the second analysis device is a CMOS-based spectrometer.
15. A method according to claim 14 , wherein one or more of Fourier-wave Spectrometry and Stationary Wave Integrated Fourier Transform Spectrometry are used.
16. A method according to claim 11 , wherein one or more of the selected parts of the received Raman optical spectrum is coupled to a dispersion member.
17. A method according to claim11 , further comprising determining the concentration of an analyte.
18. A method according to claim 17 , wherein the analyte is selected from the group consisting of glucose, lactate, fatty acids, urea, carbamide, cholesterol, alcohol and hemoglobin.