IP Library › Patent Application 17991448
Patent Application
App. No. 17/991,448

MODULATORS OF HEMOGLOBIN

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Quick Facts
Patent No.
US None
App. No.
17/991,448
Abstract

The present disclosure relates generally to compounds and pharmaceutical compositions suitable as modulators of hemoglobin, and methods for their use in treating disorders mediated by hemoglobin.

Claims (11)

1 .- 20 . (canceled)

21 . A method for increasing oxygen affinity of hemoglobin S in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of formula:

or a pharmaceutically acceptable salt thereof.

22 . The method of claim 21 , comprising administering to the subject a therapeutically effective amount of a compound of formula:

23 . A method for treating a disorder mediated by hemoglobin in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of formula:

or a pharmaceutically acceptable salt thereof.

24 . The method of claim 23 , comprising administering to the subject a therapeutically effective amount of a compound of formula:

25 . The method of claim 23 , wherein the hemoglobin is sickle hemoglobin.

26 . A method for treating sickle cell disease in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of formula:

or a pharmaceutically acceptable salt thereof.

27 . The method of claim 26 , comprising administering to the subject a therapeutically effective amount of a compound of formula:

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 9, 2023
From: LI, ZHE
To: GLOBAL BLOOD THERAPEUTICS, INC.
Reel/Frame 062935/0687 →