IP Library › Patent Application 17993389
Patent Application
App. No. 17/993,389

ISOTOPE-ENRICHED 3-AMINO-1-PROPANESULFONIC ACID DERIVATIVES AND USES THEREOF

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Quick Facts
Patent No.
US None
App. No.
17/993,389
Abstract

There are provided isotope-enriched compounds of Formula (I) and pharmaceutically acceptable salts or esters thereof, as well as pharmaceutical compositions thereof and methods of use thereof for prevention and treatment of amyloid-β related diseases, such as Alzheimer's disease. R 1 R 2 X—CR 2 —CH 2 —CH 2 —SO 3 H  (I)

Claims (8)

1 . A compound of Formula (I), or a pharmaceutically acceptable salt or ester thereof:

R 1 R 2 X—CR 2 —CH 2 —CH 2 —SO 3 H  (I)

where:

R 1 and R 2 are independently a hydrogen of natural abundance or a protecting group, wherein said protecting group is isotope-enriched or non-isotope enriched, said protecting group being selected from acyl, carbonyl, thiocarbonyl, and carbamoyl groups;

X is a nitrogen of natural abundance or 15 N, or a combination thereof, and

R is a hydrogen of natural abundance, a deuterium (D) or a combination thereof,

provided that at least one of X, R, R 1 and R 2 comprises an atom that is not of natural abundance.

2 .- 41 . (canceled)