METHODS OF TREATING VIRAL INFECTIONS
The disclosure is directed to methods of using dantrolene or a dantrolene prodrug, or a pharmaceutically acceptable salt thereof, to treat viral infections.
1 . A method of treating a viral infection in a subject comprising administering to the subject dantrolene or a pharmaceutically acceptable salt thereof or by administering a dantrolene prodrug or a pharmaceutically acceptable salt thereof.
2 . The method of claim 1 , comprising administering dantrolene to the subject.
3 . The method of claim 1 , comprising administering a pharmaceutically acceptable salt of dantrolene to the subject.
4 . The method of claim 1 , comprising administering dantrolene sodium to the subject.
5 . A method for inhibiting replication of a virus in a subject comprising administering to the subject dantrolene, or a pharmaceutically acceptable salt thereof or by administering a dantrolene prodrug or a pharmaceutically acceptable salt thereof.
6 . The method of claim 5 , comprising administering dantrolene to the subject.
7 . The method of claim 5 , comprising administering a pharmaceutically acceptable salt of dantrolene to the subject.
8 . The method of claim 5 , comprising administering dantrolene sodium to the subject.
9 . A method for inhibiting replication of a virus in a host cell, for inhibiting entry of a virus into a host cell, for inhibiting a virion maturation in a host cell, or for inhibiting release of a virus from a host cell comprising administering to the host cell dantrolene, or a pharmaceutically acceptable salt thereof or by administering a dantrolene prodrug or a pharmaceutically acceptable salt thereof.
10 . The method of claim 9 , comprising administering dantrolene to the host cell.
11 . The method of claim 9 , comprising administering a pharmaceutically acceptable salt of dantrolene to the host cell.
12 . The method of claim 9 , comprising administering dantrolene sodium to the host cell.
13 . A method for reducing the infectivity of a virus by administering to a host cell dantrolene, or a pharmaceutically acceptable salt thereof or by administering a dantrolene prodrug or a pharmaceutically acceptable salt thereof.
14 . The method of claim 13 , comprising administering dantrolene to the host cell.
15 . The method of claim 13 , comprising administering a pharmaceutically acceptable salt of dantrolene to the host cell.
16 . The method of claim 13 , comprising administering dantrolene sodium to the host cell.