IP Library › Granted Patent US 12,577,229
Granted Patent B2
US 12,577,229 · App. 17/997,258 · Granted Mar 17, 2026

Substituted {5-methoxy-6-[(5-methoxypyridin-2-yl)methoxy]pyridin-3-yl} methyl compounds as CSF-1R inhibitors

Inventor: Simon James Richards (Hannington, GB)
Assignee: Eli Lilly and Company
C07D401/14
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Quick Facts
Patent No.
US 12,577,229
App. No.
17/997,258
Granted
Mar 17, 2026
Kind
B2
Abstract

The present invention provides a compound of Formula I: Formula I or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising the compound and to methods of using the compound to treat physiological disorders.

Claims (9)

1 . A compound of the formula:

or a pharmaceutically acceptable salt thereof.

2 . A method of treating Alzheimer's disease in a patient in need thereof, comprising administering to the patient an effective amount of the compound of claim 1 , or a pharmaceutically acceptable salt thereof.

3 . A pharmaceutical composition, comprising an effective amount of the compound, or a pharmaceutically acceptable salt thereof, of claim 1 and one or more pharmaceutically acceptable carrier, diluent, or excipient.

4 . A process for preparing a pharmaceutical composition, comprising admixing the compound, or a pharmaceutically acceptable salt thereof, of claim 1 with one or more pharmaceutically acceptable carrier, diluent, or excipient.

5 . A compound of the formula:

6 . A pharmaceutical composition comprising an effective amount of the compound of claim 5 and one or more pharmaceutically acceptable carrier, diluent, or excipient.

7 . A process for preparing a pharmaceutical composition, comprising admixing the compound of claim 5 with one or more pharmaceutically acceptable carriers, diluents, or excipients.

8 . A method of treating Alzheimer's disease in a patient in need thereof, comprising administering to the patient an effective amount of the compound of claim 5 .

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 27, 2022
From: RICHARDS, SIMON JAMES
To: ELI LILLY AND COMPANY
Reel/Frame 061558/0881 →
Continuity (2)
Provisional Application 63020093 · May 5, 2020
Related Publication 20230167086A1 · Jun 1, 2023
References Cited (5)
US 11992535B2 · Liu · 2024 [cited by examiner]
WO 2011150198 · 2011 [cited by applicant]
WO 2014001802 · 2014 [cited by applicant]
International Search Report of PCT/US2021/028773 (filed Apr. 23, 2021 by Eli Lilly and Company), Search completed on Jun. 11, 2021, Mailed on Jun. 25, 2021 by the European Patent Office, 5 pages. [cited by applicant]
International Written Opinion of PCT/US2021/028773 (filed Apr. 23, 2021 by Eli Lilly and Company), Search completed on Jun. 11, 2021, Mailed on Jun. 25, 2021 by the European Patent Office, 6 pages. [cited by applicant]