Non-isocyanate polyurethane elastomers and compositions comprising such elastomers
The present disclosure relates to gel compositions of, or containing, a non-isocyanate polyurethane (NIPU) elastomer formed from the reaction of a polycarbonate, where carbonate groups may be cyclic or non-cyclic, and a polyamine, where amines are either primary or secondary, in an optional topically acceptable carrier fluid. The gelled compositions may further contain a personal or healthcare active. The actives may be incorporated into the gel via either a pre or post load method.
1 . A gel composition comprising a non-isocyanate polyurethane (NIPU) elastomer being a reaction product of:
A) a polycarbonate or a mixture of polycarbonates comprising two or more carbonate functional groups;
B) a polyamine or mixture of polyamines comprising two or more amine functional groups, where the amine functional groups are either primary or secondary;
C) an NIPU reaction catalyst; and
D) a topically acceptable carrier fluid, wherein the topically acceptable carrier fluid is a reaction solvent at a concentration of between 50% (w/w) and 99.9% (w/w) of the gel composition; and
wherein particles of the non-isocyanate polyurethane (NIPU) elastomer are dispersed in the topically acceptable carrier fluid;
wherein the gel composition further comprises a pharmaceutically active ingredient, the pharmaceutically active ingredient being dissolved in the topically acceptable carrier fluid, or the pharmaceutically active ingredient being incorporated in the gel; and
wherein the gel composition further comprises an oil phase and a water phase.
2 . The gel composition of claim 1 , wherein the topically acceptable carrier fluid is selected from the group consisting of esters, triglycerides, hydrocarbons, silicone fluids, diisooctyl succinate, heptyl undecylenate, neopentyl glycol diheptanoate, and coco caprylate, and combinations thereof.
3 . The gel composition of claim 1 wherein the polycarbonate or mixture of polycarbonates is a low molecular weight polycarbonate or mixture of polycarbonates containing two or more hydroxyl groups and wherein the polyamine or mixture of polyamines is a low molecular weight polyamine or mixture of polyamines containing two or more primary or secondary amines.
4 . A topical composition:
the gel composition of claim 1 , wherein the pharmaceutically active ingredient is a personal care active ingredient or a healthcare active ingredient.
5 . The gel composition of claim 1 , wherein the topically acceptable carrier fluid, is at a concentration of between 60% (w/w) and 99.9% (w/w) of the gel composition.
6 . A topical formulation comprising the gel composition of claim 5 .
7 . The gel composition of claim 1 , further comprising an emulsifier.
8 . The gel composition of claim 1 , wherein the pharmaceutically active ingredient comprises sunburn prevention and treatment agents.