IP Library › Granted Patent US 12,637,417
Granted Patent B2
US 12,637,417 · App. 18/007,370 · Granted May 26, 2026

Method for producing 2-(halogenated methyl)naphthalene and 2-naphthyl acetonitrile

Inventors: Shunsuke Tsuji (Chiyoda-ku, JP); Masaki Nagahama (Chiyoda-ku, JP); Hirotsugu Taniike (Chiyoda-ku, JP)
Assignee: UBE Corporation
C07C255/33C07C22/04
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Quick Facts
Patent No.
US 12,637,417
App. No.
18/007,370
Granted
May 26, 2026
Kind
B2
Abstract

A method for producing a 2-(halogenated methyl)naphthalene represented by general formula (1): where X is a halogen atom. The method includes a halogenation process of reacting 2-methylnaphthalene with a halogenating agent under light irradiation, in an organic solvent selected from a halogenated hydrocarbon, an aliphatic ester and an aliphatic hydrocarbon.

Claims (16)

1 . A method for producing a 2-(halogenated methyl) naphthalene of formula (1):

wherein

X is a halogen atom,

the method comprising:

flow synthesis reaction in an open system of 2-methylnaphthalene with a halogenating agent under light irradiation, in methyl acetate,

wherein

a temperature of the flow synthesis reaction is from −20° C. to 55° C., and

the flow synthesis reaction does not comprise an additive.

2 . The method according to claim 1 , wherein the halogenating agent is a brominating agent.

3 . The method according to claim 1 , wherein the light irradiation is performed with light having a wavelength of from 280 nm to 700 nm.

4 . A method for producing 2-naphthylacetonitrile, comprising:

flow synthesis reaction in an open system of 2-methylnaphthalene with a halogenating agent under light irradiation, in methyl acetate to produce a 2-(halogenated methyl) naphthalene of formula (1):

wherein X is a halogen atom; and

cyanation of the 2-(halogenated methyl) naphthalene with a cyanating agent, in a solvent, wherein

a temperature of the flow synthesis reaction is from −20° C. to 55° C., and

the flow synthesis reaction does not comprise an additive.

Assignments (3)
MERGER Recorded Mar 2, 2026
From: API CORPORATION
To: UBE CORPORATION
Reel/Frame 075299/0648 →
ADDRESS CHANGE Recorded Apr 13, 2023
From: API CORPORATION
To: API CORPORATION
Reel/Frame 063325/0621 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 30, 2023
From: TSUJI, SHUNSUKE; NAGAHAMA, MASAKI; TANIIKE, HIROTSUGU
To: API CORPORATION
Reel/Frame 062532/0252 →
Priority Claims (1)
JP 2020-146244 · Aug 31, 2020 · national
Continuity (1)
Related Publication 20240109840A1 · Apr 4, 2024
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