Microfluidic component with metal layer stack and fluid conduit element made of another material bonded with it
A microfluidic component for a sample separation device includes a layer body with multiple metal layer structures that are connected with each other, and an element made of a material different from the metal layer structures, which includes at least one microfluidic structure and is bonded with the layer body.
1 . A microfluidic component for a sample separation device, the microfluidic component comprising:
a layer body comprising a plurality of metal layer structures connected to each other; and
an element having a material composition different from a material composition of the metal layer structures, wherein the element comprises at least one microfluidic structure and is bonded with the layer body,
wherein the layer body has a cavity and the element is disposed in the cavity such that the element is embedded in the layer body.
2 . The microfluidic component according to claim 1 , wherein the microfluidic component is selected from the group consisting of: a fluid valve; a component of a fluid valve; a stator component of a fluid valve; a rotor component of a fluid valve; a sample separation unit; a part of a sample separation unit; a sample enrichment unit; a part of a sample enrichment unit; a heat exchanger; and a mixer.
3 . The microfluidic component according to claim 1 , wherein the element comprises an undercut disposed in the cavity under at least one of the metal layer structures.
4 . The microfluidic component according to claim 1 , wherein the element is embedded in the layer body such that the element comprises an exposed functional surface that is exposed to a region outside of the microfluidic component.
5 . The microfluidic component according to claim 4 , comprising at least one of the following features:
wherein the exposed functional surface of the element is aligned with an exterior surface of the layer body;
wherein, at the exposed functional surface of the element, the at least one microfluidic structure is accessible from the region outside of the microfluidic component.
6 . The microfluidic component according to claim 1 , comprising one of the following features:
wherein at least one of the metal layer structures of the layer body comprises at least one further microfluidic structure;
wherein at least one of the metal layer structures of the layer body comprises at least one further microfluidic structure fluidically coupled with the at least one microfluidic structure of the element.
7 . The microfluidic component according to claim 1 , wherein the element is a disk or a stepped disk.
8 . The microfluidic component according to claim 4 , wherein the exposed functional surface of the element comprises a lower roughness Ra than another exterior surface of the element.
9 . A microfluidic component for a sample separation device, the microfluidic component comprising:
a layer body comprising a plurality of metal layer structures connected to each other; and
an element having a material composition different from a material composition of the metal layer structures, wherein the element comprises at least one microfluidic structure and is bonded with the layer body,
wherein the element further comprises a collar that is interrupted in a circumferential direction around the collar.
10 . A microfluidic component for a sample separation device, the microfluidic component comprising:
a layer body comprising a plurality of metal layer structures connected to each other; and
an element having a material composition different from a material composition of the metal layer structures, wherein the element comprises at least one microfluidic structure and is bonded with the layer body, and wherein:
the element further comprises an exposed functional surface that is exposed to a region outside of the microfluidic component; and
the element further comprises a circumferential collar which, at least in portions of the circumferential collar, comprises a compression ring protruding in a direction toward the exposed functional surface of the element.
11 . The microfluidic component according to claim 1 , wherein the element is disposed in the cavity such that the element is surrounded by at least two metal layer structures of the plurality of metal layer structures.
12 . The microfluidic component according to claim 1 , wherein the element comprises a bottom side, the plurality of metal layer structures comprises an adjoining metal layer structure that adjoins the bottom side of the element, and the adjoining metal layer structure comprises at least one balancing recess configured to balance thermal expansion phenomena during bonding due to different coefficients of thermal expansion of the element and the metal layer structures.
13 . A sample separation device for separating a fluidic sample, the sample separation device comprising:
a fluid drive configured to drive a mobile phase and the fluidic sample contained therein;
a sample separation unit configured to separate the fluidic sample in the mobile phase; and
the microfluidic component according to claim 1 , wherein the fluidic sample and/or the mobile phase is to be delivered through the at least one microfluidic structure during the separation.
14 . The sample separation device according to claim 13 , further comprising at least one of the following features:
the sample separation unit is configured as a chromatographic separation unit;
the sample separation device is configured for analyzing at least one physical, chemical and/or biological parameter of at least one fraction of the fluidic sample;
the sample separation device comprises a device selected from the group consisting of: a device for a chemical, biological and/or pharmaceutical analysis; a chromatography device; a liquid chromatography device; a gas chromatography device; a device for supercritical liquid chromatography; a high-pressure liquid chromatography device; an ultra-high-pressure liquid chromatography device; an electrophoresis device; and a gel electrophoresis device;
the fluid drive is configured to drive the mobile phase with a pressure of at least 100 bar;
the fluid drive is configured to drive the mobile phase with a pressure of at least 500 bar;
the fluid drive is configured to drive the mobile phase with a pressure of at least 1000 bar;
the sample separation device is configured as a microfluidic device;
the sample separation device is configured as a nanofluidic device;
the sample separation device comprises a sample insertion unit configured to insert the fluidic sample into a fluidic path between the fluid drive and the sample separation unit;
the sample separation device comprises a detector for detecting the separated fluidic sample;
the sample separation device comprises a sample fractionator configured to fractionize the separated fluidic sample.
15 . The microfluidic component according to claim 1 , wherein the at least one microfluidic structure comprises a feature selected from the group consisting of:
a structure configured to conduct fluid through the structure;
a structure configured to conduct fluid through the structure and at least partially filled with a stationary phase;
a structure configured to conduct fluid through the structure and having an inner diameter in a range between 0.05 mm and 1 mm;
a structure configured to conduct fluid through the structure and having an inner diameter in a range between 0.1 mm and 0.5 mm;
a fully circumferentially limited channel; and
a groove.
16 . The microfluidic component according to claim 1 , wherein the metal layer structures are composed of stainless steel or iron.
17 . The microfluidic component according to claim 1 , wherein the element comprises a material selected from the group consisting of: a non-metallic material; a ceramic; aluminum oxide; and zirconium oxide.