IP Library Granted Patent US 11,925,449
Granted Patent B2
US 11,925,449 · App. 18/033,179 · Granted Mar 12, 2024

Electrical impedance imaging method, system, storage medium, and electronic device

Inventors: Ke Zhang (Beijing, CN); Xin Zhang (Beijing, CN); Mingtao Guan (Beijing, CN); Yibing Wang (Beijing, CN)
Assignees: BEIJING HUARUI BOSHI MEDICAL IMAGING TECHNOLOGY CO., LTD.; TSINGHUA UNIVERSITY
A61B5/0536
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Quick Facts
Patent No.
US 11,925,449
App. No.
18/033,179
Granted
Mar 12, 2024
Kind
B2
Abstract

An electrical impedance imaging method, a system, a storage medium and an electronic device. Said method comprises: acquiring electrical impedance measurement signals of a tested human body area at a plurality of measurement times; for the electrical impedance measurement signal at each measurement time, constructing a corresponding instantaneous differential image on the basis of the electrical impedance measurement signal; constructing an image matrix on the basis of the instantaneous differential images corresponding to the plurality of measurement times, each column in the image matrix being a vector corresponding to the instantaneous differential image; determining, on the basis of the image matrix, a covariance matrix corresponding to the image matrix; obtaining, according to the covariance matrix, a weight vector of the covariance matrix; and obtaining, on the basis of the covariance matrix and the weight vector, an electrical impedance state image of the tested human body area.

Claims (51)

1. An electrical impedance imaging method, comprising:

acquiring electrical impedance measurement signals of a tested human body area at a plurality of measurement times;

for the electrical impedance measurement signal at each measurement time, constructing a corresponding instantaneous differential image on a basis of the electrical impedance measurement signal;

constructing an image matrix on a basis of the instantaneous differential images at the plurality of measurement times, wherein each column in the image matrix is a vector corresponding to the respective instantaneous differential image, and wherein the image matrix is:

I =(α( t 1 ),α( t 2 ), . . . ,α( t N ))

where I is the image matrix, a(t 1 ) is a vector corresponding to the instantaneous differential image at a first measurement time, a(t 2 ) is a vector corresponding to the instantaneous differential image at a second measurement time, and a(t N ) is a vector corresponding to the instantaneous differential image at an N-th measurement time;

determining, on a basis of the image matrix, a covariance matrix corresponding to the image matrix;

obtaining, according to the covariance matrix, a weight vector of the covariance matrix; and

obtaining, on a basis of the covariance matrix and the weight vector, an electrical impedance state image of the tested human body area.

2. The method according to claim 1 , wherein the acquiring electrical impedance measurement signals of the tested human body area at the plurality of measurement times further comprises:

fixing an electrode array around the tested human body area, wherein the electrode array comprises a plurality of electrodes; and

exciting the tested human body area by the electrode array and measuring a resulting response.

3. The method according to claim 1 , wherein the determining, on the basis of the image matrix, the covariance matrix corresponding to the image matrix, further comprises:

calculating, on the basis of the image matrix, the covariance matrix corresponding to the image matrix by using a first predetermined computational equation, wherein the first predetermined computational equation is:

C =( I−Ī )·( I−Ī ) T

where C is the covariance matrix, I is the image matrix, T is a transpose of the matrix, Ī is a time-averaged matrix with a size of M*N, and each column in the time-averaged matrix is ā=1/NΣ i=1 N a(t i ), where M is a number of pixels in each frame of the instantaneous differential images, N is a number of measurement times, and a(t i ) is a vector corresponding to the instantaneous differential image at an i-th measurement time.

4. The method according to claim 1 , wherein the obtaining, according to the covariance matrix, the weight vector of the covariance matrix, further comprises:

calculating, according to the covariance matrix, the weight vector of the covariance matrix by using a second predetermined computational equation, wherein the second predetermined computational equation is:

w

*

=

arg

max

w

{

-

1

,

1

}

M

w

T

Cw

where w* is the weight vector, w is a column vector with a size of M*1, a value of elements in the column vector is 1 or −1, T is a transpose of the matrix, and C is the covariance matrix.

5. The method according to claim 1 , wherein the obtaining, on the basis of the covariance matrix and the weight vector, the electrical impedance state image of the tested human body area, further comprises:

calculating, on the basis of the covariance matrix and the weight vector, the electrical impedance state image of the tested human body area by using a third predetermined computational equation, wherein the third predetermined computational equation is:

a s =C·w*

where a s is the electrical impedance state image, C is the covariance matrix and w* is the weight vector.

6. The method according to claim 1 , wherein the constructing, for the electrical impedance measurement signal at each measurement time, the corresponding instantaneous differential image on the basis of the electrical impedance measurement signal, further comprises:

for the electrical impedance measurement signal at each measurement time, extracting a signal in a predetermined frequency range from the electrical impedance measurement signal; and

for each extracted signal in the predetermined frequency range, constructing the corresponding instantaneous differential image on the basis of the extracted signal in the predetermined frequency range by using an image reconstruction algorithm.

7. The method according to claim 6 , wherein the signal in the predetermined frequency range is extracted from the electrical impedance measurement signals by using a filter.

8. The method according to claim 6 , wherein the extracted signal is a ventilation-related signal or a blood perfusion-related signal.

9. The method according to claim 6 , wherein the image reconstruction algorithm comprises a linear least square method.

10. A non-transitory storage medium having a program code stored thereon, wherein the electrical impedance imaging method according to claim 1 is implemented when the program code is executed by a processor.

11. An electronic device, comprising a memory and a processor, wherein program code runnable on the processor is stored on the memory, and wherein the electrical impedance imaging method according to claim 1 is implemented when the program code is executed by the processor.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 1, 2023
From: BEIJING HUARUI BOSHI MEDICAL IMAGING TECHNOLOGY CO., LTD.
To: BEIJING HUARUI BOSHI MEDICAL IMAGING TECHNOLOGY CO., LTD.; TSINGHUA UNIVERSITY
Reel/Frame 065739/0075 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 21, 2023
From: ZHANG, KE; ZHANG, XIN; GUAN, MINGTAO; WANG, YIBING
To: BEIJING HUARUI BOSHI MEDICAL IMAGING TECHNOLOGY CO., LTD.
Reel/Frame 063403/0460 →
Priority Claims (1)
CN 202011145265.2 · Oct 23, 2020 · national
Continuity (1)
Related Publication 20230329575A1 · Oct 19, 2023